Software

Benchmark Software Tools

These are the currently available benchmark software tools for population kinetic analysis.

PopKinetics
A population kinetics application based upon the standard and iterated two-stage methods. Part of the SAAM II software system. Also simulates populations, and performs Monte Carlo simulations. (SAAM Institute, Inc.)

Kinetica 2000
PK-PD application for data analysis, simulation and reporting with a non-compartmental assistant technology. (Innaphase, Inc)

NLME
Programs for fitting linear and nonlinear mixed effects models. (Jose Pinheiro, Douglas M. Bates and Mary J. Lindstrom)

NLMIX
A program for Maximum Likelihood Estimation of the Nonlinear Mixed Effects Model with a Smooth Random Effects Density. (Marie Davidian and A. Ronald Gallant)

NONMEM
NONlinear Mixed Effects Modeling from "The NONMEM Project Group". (Stuart. L. Beal, Lewis B. Sheiner, Alison Boeckmann and Barbara Weichman)

PKBugs
PKBugs is an interface for specifying complex population pharmacokinetic/pharmacodynamic models within the widely-used WinBUGS software. WinBUGS is a Bayesian modeling framework that can be used to analyze, using Markov chain Monte Carlo (MCMC) techniques, arbitrarily complex Bayesian full probability models. (David J. Lunn and the BUGS Team)

SAAM II
General purpose, fully menu driven software tool for compartmental and numerical modeling. (SAAM Institute, Inc.)

USC*PACK
Programs for Population Pharmacokinetic Modeling, Clinical Programs, Programs for Infectious Diseases and Programs for Cardiology. (RW Jelliffe et al.)

WinNonMix
Program for nonlinear mixed-effects modeling provided in an interactive and easy-to-use Windows application. (Pharsight Corp.)