Name |
Department/Institution |
Research Interest |
Aderem, Alan PhD |
Institute of Systems Biology, Affiliate Immunology and Medicine |
Mechanisms of phagocytosis and cell movement; macrophage development and differentiation |
Bornfeldt, Karin E PhD |
Division of Metabolism, Endocrinology and Nutrition (Medicine), Pathology (Medicine) |
Focuses on elucidating the cellular mechanisms leading to accelerated atherosclerosis in disease states associated with inflammation, such as diabetes and, recently, lupus. Interested in understanding how monocytes, macrophages, dendritic cells, and endothelial cells are affected by these diseases. One area of interest is the interaction between fatty acids and inflammation. Overexpression or deletion acyl-CoA synthetase isoforms is performed to address whether increased or decreased fatty acyl-CoA load alters biological function. Mouse models of accelerated atherosclerosis in diabetes and lupus are used to investigate and validate the cellular and molecular mechanisms of these diseases. Models include low-density lipoprotein receptor-deficient mice, bone marrow transplanted mice, and mice treated with retroviral vectors to overexpress different proteins under myeloid cell-selective promoters. |
Buckner, Jane MD |
Benaroya Research Institute
Medicine-Rheumatology |
Regulation of the human immune response to self-antigens and the pathogenic mechanisms and autoimmunity |
Byers, Peter MD |
Pathology (Medicine) |
the characterization of mutations of collagen genes that give rise to forms of osteogenesis imperfecta , Ehlers-Danlos syndrome type IV, and other forms of connective tissue disorders |
Clark, Edward PhD |
Microbiology (Immunology) |
Regulation of B-cell and dendritic cell survival and death; molecules regulating germinal center formation. |
Dugowson, Carin MD, MPH |
Medicine-Rheumatology (Epidemiology) |
Epidemiology of musculoskeletal diseases |
Elkon, Keith MD |
Medicine-Rheumatology (Immunology) |
Inflammation in systemic autoimmune disease, Apoptotic Cells |
Eyre, David PhD |
Orthopaedics and Sports Medicine |
molecular mechanisms of collagen cross-linking, cartilage matrix biology and pathology, matrix protein defects and the pathogenesis of chondrodysplasia syndromes and novel molecular markers of bone and cartilage metabolism |
Hughes, Grant MD |
Medicine-Rheumatology |
Regulation of lupus autoimmunity by female reproductive hormones |
Jarvik, Jerry MD, MPH |
Radiology, Neurosurgery, Health Services |
The imaging of low back pain and peripheral nerve disorders |
Ledbetter, Jeffery PhD |
Medicine-Rheumatology (Microbiology) |
The role of CD180 in B cell and dendritic cell function. |
Nelson, J. Lee MD |
Medicine-Rheumatology, Fred Hutchinson Cancer Research Center |
Effects of microchimerism, relating to including autoimmune diseases, pregnancy, and cancer |
Nepom, Gerry MD, PhD |
Benaroya Research Institute
(UW-SOM Immunology) |
Molecular and genetic mechanisms contributing to triggering autoimmune disorders, in particular, the role of HLA class II genes |
Rawlings, David MD, PhD |
Pediatrics (Immunology) |
Dysregulated B cell development and signaling leading to immunodeficiency, autoimmunity, or lymphoid malignancies; Gene therapy for primary immunodeficiency |
Rubens, Craig MD, PhD |
Pediatrics |
Molecular pathogenesis of bacterial perinatal infections and bacterial pneumonia |
Scharenberg, Andrew MD, PhD |
Pediatrics |
Signal transduction mechanisms and cation channel function in the immune system |
Schwartz, Steven MD, PhD |
Pathology |
Growth control of vessel wall cells and Regulator of G-protein signaling (RGS5) Vascular abnormalities of scleroderma |
Stevens, Anne MD, PhD |
Pediatrics |
Microchimerism and pediatric SLE
PDL 1 in SLE |
Torgerson, Troy MD, PhD |
Pediatrics |
Autoimmunity/immunodeficiency (IPEC/Fox 3P) |
Wallace, Carol MD |
Pediatrics |
Clinical investigation/outcomes research |
Wener, Mark MD |
Laboratory Medicine (Medicine-Rheumatology) |
Mechanism of immune complex deposition in lupus nephritis ,Central nervous system lupus,
Stem cell transplant for autoimmune rheumatic disease |
Ziegler, Steven PhD |
Benaroya Research Institute (Immunology) |
Genetic and molecular analysis of immune system regulation; mechanisms of cytokine-mediated signal transduction; T regulatory cells, & SLP |