Faculty
Grant Hughes, M.D.
Assistant Professor of Medicine
OFFICE ADDRESS
University of Washington
1959 NE Pacific Street
Box 356428
Seattle, WA 98195-6428
Telephone: (206) 543-3414
FAX (206) 685-9397
EDUCATION AND TRAINING
Acting Instructor, Post-doctoral fellow, University of Washington 2005-2009
Fellowship, University of Washington, 2003-2005
Internal Medicine Residency, University of Washington, 2001-2002
MD, Oregon Health and Sciences University, 2001
Fulbright Scholar, University of Oslo, Noway, 1995-1996
CURRENT RESEARCH INTERESTS
Dendritic cells and female sex steroids. Read more about his research here...
REPRESENTATIVE PUBLICATIONS
Hughes GC, Martin D, Zhang K, Hudkins KL, Alpers CE, Clark EA, Elkon KB. Decrease in glomerulonephritis and Th1-associated autoantibody production after progesterone treatment in NZB/NZW mice. Arthritis Rheum. 2009 Jun;60(6):1775-84.
Hughes GC, Thomas S, Li C, Kaja M, Clark EA. Progesterone regulates interferon-alpha production by plasmacytoid dendritic cells. J Immunol 2008;180:2029-2033.
Martin DA, Zhang K, Kenkel J, Hughes G, Clark E, Davidson A, Elkon KB. Autoimmunity stimulated by adoptively transferred dendritic cells is initiated by both ab and gd T-cells but does not require MyD88 signaling. J Immunol 2007;179:5819-5828.
Hughes GC, Clark EA. Regulation of dendritic cells by female sex steroids: relevance to immunity and autoimmunity. Autoimmunity 2007;40:470-481
Koh P, Hughes GC, Faulkner G, Keeble W, Bagby G. The Fanconi anemia group C gene product modulates apoptotic responses to tumor necrosis factor- and Fas ligand but does not suppress expression of receptors of the tumor necrosis factor receptor subfamily. Experimental Hematology 1999;27:1-8.
Rathbun R, Faulkner G, Ostroski M, Christianson T, Hughes GC, Jones G, Cahn R, Maziarz R, Royle G, Keeble W, Heinrich M, Grompe M, Tower A, Bagby G. Inactivation of the Fanconi anemia group C gene augments interferon-gamma-induced apoptotic responses in hematopoietic cells. Blood 1997;90:974-85