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Division of Rheumatology
1959 NE Pacific St
Health Science Bldg BB561
Campus Box 356428
Seattle, WA 98195

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Phone: 206-543-3414

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Grant C. Hughes, M.D.

Associate Professor of Medicine
Harborview Section Head

Fellowship Program Director

Division of Rheumatology 

750 Republican Street
Box 358060
Seattle, WA 98109


Phone: 206-543-3414
Fax: 206-685-9397
Email: hughesg@uw.edu




  • Acting Instructor, Post-doctoral fellow, University of Washington 2005-2009
  • Fellowship, University of Washington, 2003-2005
  • Internal Medicine Residency, University of Washington, 2001-2002
  • MD, Oregon Health and Sciences University, 2001
  • Fulbright Scholar, University of Oslo, Noway, 1995-1996




Female reproductive hormones and lupus autoimmunity. Read more about his research here...





  • Lood C, Hughes GC. Neutrophil extracellular traps as a potential source of autoantigen in cocaine-associated autoimmunity. Rheumatology (Oxford). 2016 Jun 27. pii.kew256.


  • Gazitt T, Thomason JHughes GC. The Reply. Am J Med. 2016 Jan;129(1):e19. doi: 10.1016/j.amjmed.2015.09.003. No abstract available. PMID: 26703010


  • Tsur A, Hughes GC, Schoenfeld Y.  Interdisciplinary exchange of ideas: progestagens for autoimmunity, biologics for pregnancy complications.  Immunol Res 2015;61:31-4.


  • Wong A, Agrawal N, Hughes GC.  The nuclear progesterone receptor regulates IgG2c autoantibodies, T follicular helper  and regulator T cells in lupus-prone Nba2 mice.  Autoimmunity 2015;10:1-13.


  • *Hughes GC, Choubey D.  Modulation of autoimmune rheumatic diseases by oestrogen and progesterone.  Nat Rev Rheumatol 2014 Aug 26. doi: 10.1038/nrrheum.2014.144. [Epub ahead of print]


  • HughesGC, Clark EA, Wong AH.  The intracellular progesterone receptor regulates CD4+ T cells and T cell-dependent antibody responses.  J Leukoc Biol 2013;93:369-375.


  • Hughes GC, Clark EA, Wong AH. The intracellular progesterone receptor regulates CD4+ T cells and T cell-dependent antibody responses. J Leukoc Biol. 2013 Mar;93(3):369-75. doi: 10.1189/ jlb.1012491.


  • Hughes GC. Progesterone and autoimmune disease. Autoimmun Rev. 2012 May;11(6-7): A502-14. Epub 2011 Dec 13.


  • Hughes GC, Martin D, Zhang K, Hudkins KL, Alpers CE, Clark EA, Elkon KB. Decrease in glomerulonephritis and Th1-associated autoantibody production after progesterone treatment in NZB/NZW mice. Arthritis Rheum. 2009 Jun;60(6):1775-84.


  • Hughes GC, Thomas S, Li C, Kaja M, Clark EA. Progesterone regulates interferon-alpha production by plasmacytoid dendritic cells. J Immunol 2008;180:2029-2033.




Quick Links:

Hughes Lab | Division Publications | Clinical Faculty



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