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Division of Rheumatology
1959 NE Pacific St
Health Science Bldg BB561
Campus Box 356428
Seattle, WA 98195

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Phone: 206-543-3414

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Grant C. Hughes, M.D.

Associate Professor of Medicine
Harborview Section Head

Fellowship Program Director

Division of Rheumatology 

750 Republican Street
Box 358060
Seattle, WA 98109


Phone: 206-543-3414
Fax: 206-685-9397
Email: hughesg@uw.edu




  • Acting Instructor, Post-doctoral fellow, University of Washington 2005-2009
  • Fellowship, University of Washington, 2003-2005
  • Internal Medicine Residency, University of Washington, 2001-2002
  • MD, Oregon Health and Sciences University, 2001
  • Fulbright Scholar, University of Oslo, Noway, 1995-1996




Female reproductive hormones and lupus autoimmunity. Read more about his research here...





Hughes GC, Clark EA, Wong AH. The intracellular progesterone receptor regulates CD4+ T cells and T cell-dependent antibody responses. J Leukoc Biol. 2013 Mar;93(3):369-75. doi: 10.1189/ jlb.1012491.

Hughes GC. Progesterone and autoimmune disease. Autoimmun Rev. 2012 May;11(6-7): A502-14. Epub 2011 Dec 13.

Hughes GC, Martin D, Zhang K, Hudkins KL, Alpers CE, Clark EA, Elkon KB. Decrease in glomerulonephritis and Th1-associated autoantibody production after progesterone treatment in NZB/NZW mice. Arthritis Rheum. 2009 Jun;60(6):1775-84.

Hughes GC, Thomas S, Li C, Kaja M, Clark EA. Progesterone regulates interferon-alpha production by plasmacytoid dendritic cells. J Immunol 2008;180:2029-2033.

Martin DA, Zhang K, Kenkel J, Hughes G, Clark E, Davidson A, Elkon KB. Autoimmunity stimulated by adoptively transferred dendritic cells is initiated by both ab and gd T-cells but does not require MyD88 signaling. J Immunol 2007;179:5819-5828.

Hughes GC, Clark EA. Regulation of dendritic cells by female sex steroids: relevance to immunity and autoimmunity. Autoimmunity 2007;40:470-481.

Koh P, Hughes GC, Faulkner G, Keeble W, Bagby G. The Fanconi anemia group C gene product modulates apoptotic responses to tumor necrosis factor- and Fas ligand but does not suppress expression of receptors of the tumor necrosis factor receptor subfamily. Experimental Hematology 1999;27:1-8.

Rathbun R, Faulkner G, Ostroski M, Christianson T, Hughes GC, Jones G, Cahn R, Maziarz R, Royle G, Keeble W, Heinrich M, Grompe M, Tower A, Bagby G. Inactivation of the Fanconi anemia group C gene augments interferon-gamma-induced apoptotic responses in hematopoietic cells. Blood 1997;90:974-85.



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Hughes Lab | Division Publications | Clinical Faculty



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