Quick Links

How to Find Us

Division of Rheumatology
1959 NE Pacific St
Health Science Bldg BB561
Campus Box 356428
Seattle, WA 98195

Email Us

Phone: 206-543-3414

Click here for directions & other rheumatology locations.


Grant C. Hughes, M.D.

Associate Professor of Medicine
Harborview Section Head

Fellowship Program Director

Division of Rheumatology 

750 Republican Street
Box 358060
Seattle, WA 98109


Phone: 206-543-3414
Fax: 206-685-9397
Email: hughesg@uw.edu




  • Acting Instructor, Post-doctoral fellow, University of Washington 2005-2009
  • Fellowship, University of Washington, 2003-2005
  • Internal Medicine Residency, University of Washington, 2001-2002
  • MD, Oregon Health and Sciences University, 2001
  • Fulbright Scholar, University of Oslo, Noway, 1995-1996




Female reproductive hormones and lupus autoimmunity. Read more about his research here...





  • Gazitt T, Thomason JHughes GC. The Reply. Am J Med. 2016 Jan;129(1):e19. doi: 10.1016/j.amjmed.2015.09.003. No abstract available. PMID: 26703010


  • Schechter MA, Shah AA, Englum BR, Williams JB, Ganapathi AM, Davies JD, Welsby IJ, Hughes GCProlonged postoperative respiratory support after proximal thoracic aortic surgery: Is deep hypothermic circulatory arrest a risk factor? J Crit Care. 2016 Feb;31(1):125-9. doi: 10.1016/j.jcrc.2015.10.021. Epub 2015 Nov 6. PMID: 26700606


  • Keenan JE, Wang H, Ganapathi AM, Englum BR, Kale E, Mathew JP, Husain AM, Hughes GC Electroencephalography During Hemiarch Replacement With Moderate Hypothermic Circulatory Arrest. Ann Thorac Surg. 2016 Feb;101(2):631-7. doi: 10.1016/j.athoracsur.2015.08.002. Epub 2015 Oct 17. PMID: 26482779


  • Conte JV, Gleason TG, Resar JR, Adams DH, Deeb GM, Popma JJ, Hughes GC, Zorn GL, Reardon MJ. Transcatheter or Surgical Aortic Valve Replacement in Patients With Prior Coronary Artery Bypass Grafting. Ann Thorac Surg. 2016 Jan;101(1):72-9. doi: 10.1016/j.athoracsur.2015.06.067. Epub 2015 Oct 1. PMID: 26433523


  • Hughes GC, Mathew JP. Invited Commentary. Ann Thorac Surg. 2016 Jan;101(1):152-3. doi: 10.1016/j.athoracsur.2015.07.045. No abstract available. PMID: 26694265


  • Benrashid E, Wang H, Keenan JE, Andersen ND, Meza JM, McCann RL, Hughes GC. Evolving practice pattern changes and outcomes in the era of hybrid aortic arch repair. J Vasc Surg. 2015 Oct 27. pii: S0741-5214(15)01951-5. doi: 10.1016/j.jvs.2015.09.004. [Epub ahead of print] PMID: 26518097


  • Kiefer TL, Vavalle J, Hurwitz LM, Hughes GC, Harrison JK. Resolution of severe hemolysis and paravalvular aortic regurgitation employing an Amplatzer Vascular Plug 4: the importance of detailed pre-procedural planning using CT angiography. Cardiovasc Interv Ther. 2015 Oct 19. [Epub ahead of print] PMID: 26482076


  • Hughes GC, Clark EA, Wong AH. The intracellular progesterone receptor regulates CD4+ T cells and T cell-dependent antibody responses. J Leukoc Biol. 2013 Mar;93(3):369-75. doi: 10.1189/ jlb.1012491.


  • Hughes GC. Progesterone and autoimmune disease. Autoimmun Rev. 2012 May;11(6-7): A502-14. Epub 2011 Dec 13.


  • Hughes GC, Martin D, Zhang K, Hudkins KL, Alpers CE, Clark EA, Elkon KB. Decrease in glomerulonephritis and Th1-associated autoantibody production after progesterone treatment in NZB/NZW mice. Arthritis Rheum. 2009 Jun;60(6):1775-84.


  • Hughes GC, Thomas S, Li C, Kaja M, Clark EA. Progesterone regulates interferon-alpha production by plasmacytoid dendritic cells. J Immunol 2008;180:2029-2033.




Quick Links:

Hughes Lab | Division Publications | Clinical Faculty



Go to top