Faculty
Yufeng Peng, PhD
Acting Instructor
Division of Rheumatology
EDUCATION AND TRAINING
Cornell University Medical Center - Ph.D. Immunology
Yale University School of Medicine - Postdoc Fellow
University of Washington - Postdoc Fellow
University of Washington - Acting Instructor
CURRENT RESEARCH INTERESTS
Failure to clear apoptotic cell contributes to autoimmune diseases, such as SLE. However, the cellular and molecular defects caused the failure need to be defined. Mice deficient in MFG-E8 can not clear apoptotic cell in a timely fashion. My main interest is to examine how MFG-E8 deficiency affects both innate and adaptive immunity, including: monocyte/dendritic cell differentiation, cross-presentation of apoptotic cell to T cells and B cell response to apoptotic cell associated antigen.
PUBLICATIONS
Peng Y, Laouar Y, Li MO, Green EA, Flavell RA. TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4572-7. Epub 2004 Mar 18.
Peng Y, Gorelik L, Laouar Y, Li MO, Flavell RA. TGFbeta-mediated immunoregulation. Ernst Schering Res Found Workshop. 2006;(56):155-60.
Peng Y, Kowalewski R, Kim S, Elkon KB. The role of IgM antibodies in the recognition and clearance of apoptotic cells. Mol Immunol. 2005 May;42(7):781-7. Epub 2005 Jan 16. Review.
Ogden CA, Kowalewski R, Peng Y, Montenegro V, Elkon KB. IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo. Autoimmunity. 2005 Jun;38(4):259-64.
Peng Y, Martin DA, Kenkel J, Zhang K, Ogden CA, Elkon KB.Innate and adaptive immune response to apoptotic cells. J Autoimmun. 2007 Dec;29(4):303-9.
Peng YF, Elkon KB.Peripheral CD8 T-cell responses to apoptotic cell proteins and peptides. Crit Rev Immunol. 2007;27(4):357-65. Review.
YuFeng Peng, Yvette Latchman, and Keith B. Elkon. Ly6C low monocytes differentiate into dendritic cells and cross-tolerize T cells through PDL-1. J Immunol Mar 1, 182 (5) 2009: 2777-2785.