Division of Rheumatology
1959 NE Pacific St
Health Science Bldg BB561
Campus Box 356428
Seattle, WA 98195
YuFeng Peng, Ph.D.
Acting Assistant Professor
Division of Rheumatology
750 Republican Street
SLU E531, Box 358060
Seattle, WA 98109
EDUCATION AND TRAINING
CURRENT RESEARCH INTERESTS
Failure to clear apoptotic cell contributes to autoimmune diseases, such as SLE. However, the cellular and molecular defects caused the failure need to be defined. Mice deficient in MFG-E8 can not clear apoptotic cell in a timely fashion. My main interest is to examine how MFG-E8 deficiency affects both innate and adaptive immunity, including: monocyte/dendritic cell differentiation, cross-presentation of apoptotic cell to T cells and B cell response to apoptotic cell associated antigen.
Becker L, Liu NC, Averill MM, Yuan W, Pamir N, Peng Y, Irwin AD, Fu X, Bornfeldt KE, Heinecke JW. Unique proteomic signatures distinguish macrophages and dendritic cells. PLoS One. 2012;7(3):e33297. Epub 2012 Mar 12.
Peng YF, Elkon KB. Autoimmunity in MFG-E8-deficient mice is associated with altered trafficking and enhanced cross-presentation of apoptotic cell antigens. J Clin Invest. 2011 Jun 1;121(6):2221-41. doi: 10.1172/JCI43254. Epub 2011 May 2.
Peng, YF, Latchman Y, Elkon KB. Ly6C low monocytes differentiate into dendritic cells and cross-tolerize T cells through PDL-1. J Immunol Mar 1, 182 (5) 2009: 2777-2785.
Peng YF, Elkon KB.Peripheral CD8 T-cell responses to apoptotic cell proteins and peptides. Crit Rev Immunol. 2007;27(4):357-65. Review.
Peng Y, Martin DA, Kenkel J, Zhang K, Ogden CA, Elkon KB.Innate and adaptive immune response to apoptotic cells. J Autoimmun. 2007 Dec;29(4):303-9.
Ogden CA, Kowalewski R, Peng Y, Montenegro V, Elkon KB. IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo. Autoimmunity. 2005 Jun;38(4):259-64.
Peng Y, Kowalewski R, Kim S, Elkon KB. The role of IgM antibodies in the recognition and clearance of apoptotic cells. Mol Immunol. 2005 May;42(7):781-7. Epub 2005 Jan 16. Review.
Peng Y, Gorelik L, Laouar Y, Li MO, Flavell RA. TGFbeta-mediated immunoregulation. Ernst Schering Res Found Workshop. 2006;(56):155-60.
Peng Y, Laouar Y, Li MO, Green EA, Flavell RA. TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4572-7. Epub 2004 Mar 18.