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2008 Back to Top

  1. Burbelo PD, Hirai H, Leahy H, Lernmark A, Ivarsson SA, Iadarola MJ, Notkins AL. A New Luminescence Assay for Autoantibodies to Mammalian Cell-Prepared IA-2. Diabetes Care. Jun 5, 2008.
  2. Akesson L, Gelling RW, Jensen R, Ogimoto K, Fuller JM, Pefley R, Manavi S, Lernmark A, Schwartz MW. Increased Lipid Oxidation Heralds Diabetes Onset in DR.lyp/lyp Rats. Exp Clin Endocrinol Diabetes. May 9, 2008.
  3. Ivarsson SA, Lernmark A. Comment on: Edghill et al. (2008) Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood. Diabetes 57:1034-1042, 2008.
  4. Sweet IR, Yanay O, Waldron L, Gilbert M, Fuller JM, Tupling T, Lernmark A, Osborne WR. Treatment of Diabetic Rats with Encapsulated Islets. J Cell Mol Med. March 28, 2008.
  5. Hirai H, Miura J, Hu Y, Larsson H, Larsson K, Lernmark A, Ivarsson SA, Wu T, Kingman A, TzioufasAG, Notkins AL. Selective screening of secretory vesicle-associated proteins for autoantigens in type 1 diabetes: VAMP2 and NPY are new minor autoantigens. Clin Immunol. 127:366-74, 2008.
  6. Odermarsky M, Lernmark A, Truedsson L, Liuba P. Cutaneous microvascular dysfunction is associated with human leukocyte antigen-DQ in youths with type 1 diabetes. Pediatr Res. 63:420-2, 2008.
  7. Steed J, Gilliam LK, Harris RA, Lernmark A, Hampe CS. Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein. J Immunol Methods. 334:114-21, 2008.
  8. Nalini R, Gaur LK, Maldonado M, Hampe CS, Rodriguez L, Garza G, Lernmark A, Balasubramanyam A. HLA class II alleles specify phenotypes of ketosis-prone diabetes. Diabetes Care. 31:1195-200, 2008.
  9. Lynch KF, Lernmark B, Merlo J, Cilio CM, Ivarsson SA, Lernmark A; Diabetes Prediction in Skåne (DiPiS) Study Group. Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype. J Perinatol. 28:211-7, 2008.
  10. Elfving M, Lindberg B, Lynch K, Månsson M, Sundkvist G, Lernmark A, Ivarsson SA. Number of islet autoantibodies present in newly diagnosed type 1 diabetes children born to non-diabetic mothers is affected by islet autoantibodies present at birth. Pediatr Diabetes. 9:127-34, 2008.
  11. Elfving M, Svensson J, Oikarinen S, Jonsson B, Olofsson P, Sundkvist G, Lindberg B, Lernmark A, Hyöty H, Ivarsson SA. Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age. Exp Diabetes Res. 2008;2008:271958.
  12. Larsson HE, Hansson G, Carlsson A, Cederwall E, Jonsson B, Jönsson B, Larsson K, Lynch K, Neiderud J, Lernmark A, Ivarsson SA; for the DiPiS Study Group*. Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes. Diabetologia. 51:1623-1630, 2008.
  13. Rutledge EA, Van Yserloo B, Moralejo DH, Ettinger RA, Fuller J, Gaur P, Hoehna J, Peterson M, Jensen R, Kwitek AE, Lernmark Å.
    Coordinate Expression of Multiple Gimap Genes in the Lymphopenic BB Rat.
    In Preparation.
  14. Moralejo DH, Rutledge EA, Van Yserloo B, Fuller JM, Jensen R, Hoehna JL, Lernmark Å. Gimap/GTPase family is highly expressed in the lymphoid organs of the Bio-Breeding Rat.
    In Preparation.
  15. Ettinger RA, Moralejo DH, Lobaton SD, Van Yserloo B, Rutledge EA, Daniels TL, Lernmark Å. rIan5 Protein is not Expressed in Lymphopenic BioBreeding Rats.
    In Preparation for J Biological Chemistry.
  16. Erdélyi I, Braun KR, Van Yserloo B, Rutledge EA, Van Dijk JE, Hellmen E, Wight TN, Nederbragt H. Splice variants and catabolic products of versican in mammary tumors and mammary cell lines of the dog.
    In Preparation.

 

2007 Back to Top

  1. Rui M, Hampe CS, Wang C, Ling Z, Gorus FK, Lernmark A, Pipeleers DG, De Pauw PE. Species and epitope specificity of two 65 kDa glutamate decarboxylase time-resolved fluorometric immunoassays. J Immunol Methods. 319:133-143, 2007.
  2. Hoeldtke RD, Hampe CS, Bekris LM, Hobbs G, Bryner KD, Lernmark A; The DCCT Research Group. Antibodies to GAD65 and peripheral nerve function in the DCCT. J Neuroimmunol. 185:182-189, 2007.
  3. Shaat N, Lernmark A, Karlsson E, Ivarsson S, Parikh H, Berntorp K, Groop L. A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus. Diabetologia. 50:972-979, 2007.
  4. Bekris LM, Jensen RA, Lagerquist E, Hall TR, Agardh CD, Cilio CM, Lethagen AL, Lernmark A, Robertson JA, Hampe CS. GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination. Diabet Med. 24:521-526, 2007.
  5. Niklasson B, Hultman T, Kallies R, Niedrig M, Nilsson R, Berggren PO, Juntti-Berggren L, Efendic S, Lernmark A, Klitz W. The BioBreeding rat diabetes model is infected with Ljungan virus. Diabetologia. Apr 4, 2007.
  6. Larsson HE, Lynch K, Lernmark B, Hansson G, Lernmark A, Ivarsson SA; DiPiS Study group. Relationship between increased relative birthweight and infections during pregnancy in children with a high-risk diabetes HLA genotype. Diabetologia 50:1161-1169. 2007.
  7. Laine AP, Holmberg H, Nilsson A, Ortqvist E, Kiviniemi M, Vaarala O, Akerblom HK, Simell O, Knip M, Ludvigsson J, Ivarsson SA, Larsson K, Lernmark A, Ilonen J. Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations. Dis Markers. 23:139-145, 2007.
  8. Bekris LM, Shephard C, Janer M, Graham J, McNeney B, Shin J, Zarghami M, Griffith W, Farin F, Kavanagh TJ, Lernmark A. Glutamate Cysteine Ligase Catalytic Subunit Promoter Polymorphisms and Associations with Type 1 Diabetes Age-at-onset and GAD65 Autoantibody Levels. Exp Clin Endocrinol Diabetes. 115:221-228, 2007.
  9. Sommandas V, Rutledge EA, Van Yserloo B, Fuller J, Lernmark A, Drexhage HA. Low-density cells isolated from the rat thymus resemble branched cortical macrophages and have a reduced capability of rescuing double-positive thymoctyes from apoptosis in the BB-DP rat. J Leukob Biol. [Epub ahead of print], 2007.
  10. Thomson G, Valdes AM, Noble JA, Kockum I, Grote MN, Najman J, Erlich HA, Cucca F, Pugliese A, Steenkiste A, Dorman JS, Caillat-Zucman S, Hermann R, Ilonen J, Lambert AP, Bingley PJ, Gillespie KM, Lernmark A, Sanjeevi CB, Rønningen KS, Undlien DE, Thorsby E, Petrone A, Buzzetti R, Koeleman BP, Roep BO, Saruhan-Direskeneli G, Uyar FA, Günoz H, Gorodezky C, Alaez C, Boehm BO, Mlynarski W, Ikegami H, Berrino M, Fasano ME, Dametto E, Israel S, Brautbar C, Santiago-Cortes A, Frazer de Llado T, She JX, Bugawan TL, Rotter JI, Raffel L, Zeidler A, Leyva-Cobian F, Hawkins BR, Chan SH, Castano L, Pociot F, Nerup J. Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis. Tissue Antigens. 70(2):110-27, 2007.
  11. Jensen RA, Gilliam LK, Törn C, Landin-Olsson M, Karlsson FA, Palmer JP, Kockum I, Akesson K, Lernmark B, Lynch K, Breslow N, Lernmark A; on behalf of the Diabetes Incidence Study in Sweden (DISS) group. Multiple factors affect the loss of measurable C-peptide over 6 years in newly diagnosed 15- to 35-year-old diabetic subjects. J Diabetes Complications. 21(4):205-13, 2007.
  12. Shin JH, Janer M, McNeney B, Blay S, Deutsch K, Sanjeevi CB, Kockum I, Lernmark A, Graham J. IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5. Genes Immun. 2007 Sep; 8(6):503-12.Epub 2007 Jul 19.
  13. Jonson CO, Lernmark A, Ludvigsson J, Rutledge EA, Hinkkanen A, Faresjö M. The importance of CTLA-4 polymorphism and human leukocyte antigen genotype for the induction of diabetes-associated cytokine response in healthy school children. Pediatr Diabetes. 8(4):185-92, 2007.
  14. Akesson L, Hawkins T, Jensen R, Fuller JM, Breslow NE, Lernmark A. Decreased Core Temperature and Increased beta(3)-Adrenergic Sensitivity in Diabetes-Prone BB Rats. Diabetes Technol Ther. 2007 Aug;9(4):354-62. PMID: 17705691 [PubMed - in process]
  15. Jensen R, Gilliam L, Torn C, Landin-Olsson M, Palmer J, Akesson K, Kockum I, Lernmark B, Karlsson AF, Lynch KF, Breslow N, Lernmark A, Sundkvist G; on behalf of the Diabetes Incidence Study in Sweden group. Islet cell autoantibody levels after the diagnosis of young adult diabetic patients. Diabet Med. 2007 Aug 24; [Epub ahead of print] PMID: 17725633 [PubMed - as supplied by publisher]
  16. Hampe CS, Nalini R, Maldonado MR, Hall TR, Garza G, Iyer D, Balasubramanyam A. Association of amino-terminal-specific anti-glutamate decarboxylase (GAD65) autoantibodies with beta cell functional reserve and a milder clinical phenotype in patients with GAD65 antibodies and ketosis prone diabetes mellitus. J Clin Endocrinol Metab. 92:462-7, 2007
  17. Fenalti G, Hampe CS, O'connor K, Banga JP, Mackay IR, Rowley MJ, El-Kabbani O. Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11. Mol Immunol. 44:1178-89, 2007
  18. Hampe, CS. Hall, TR, Agren, A., Rolandsson O. Longitudinal changes in Epitope recognition of Autoantibodies against Glutamate decarboxylase 65 (GAD65Ab) in Prediabetic Adults Developing Diabetes. Clin Exp Immunol. 148:72-8 2007
  19. Fenalti G, Law RHP, Buckle AM, Langendorf C, Tuck K, Rosado CJ, Faux NG, Mahmood K, Hampe CS, Banga JP, Wilce M, Schmidberger J, Rossjohn J, El-Kabbani O, Pike RN, Smith AI, Mackay IR, Rowley MJ, Whisstock JC. GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop. Nat Struct Mol Biol. 14:280-6 2007
  20. Laron Z, Hampe CS, Kordonouri O, Haberland H, Landin-Olsson M, Torn C, Lewy H. Seasonality of Month of Birth differs between Type 1 Diabetes patients with pronounced beta cell autoimmunity and individuals with lesser or absent beta cell autoimmunity. In press at Pediatruic Diabetes.
  21. Hall T R, Bogdani M, LeBoeuf R, Kirk, E, Maziarz M, Banga J P, Oak, S, Pennington C, Hampe CS. Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies.
  22. Maruyama T, Oak S, Hall TR, Banga JP, Ortqvist E, Ettinger RA, Endl J, Hampe CS. Autoantibody epitopes to the smaller isoform of glutamate decarboxylase do not differ in Swedish and Japanese type 1 diabetes patients and may be associated with high risk HLA class II alleles. Clin Exp Immunol. 2007
  23. Gilliam LK, Liese AD, Bloch CA, Davis C, Snively BM, Curb D, Williams DE, Pihoker C. Diabetes family history, autoimmunity and cardiovascular risk factors in children with diabetes in the SEARCH for Diabetes in Youth study. Pediatric Diabetes, in press, 2007.
  24. Gilliam LK, Palmer JP, Taborsky GJ. Tyramine-Mediated Activation of Sympathetic Nerves Inhibits Insulin Secretion in Humans. JCEM, in press, 2007.
  25. Sedimbi SK, Luo XR, Sanjeevi CB; Swedish Childhood Diabetes Study Group; Diabetes Incidence in Sweden Study Group, Lernmark A, Landin-Olsson M, Arnqvist H, Björck E, Nyström L, Ohlson LO, Scherstén B, Ostman J, Aili M, Bååth LE, Carlsson E, Edenwall H, Forsander G, Granström BW, Gustavsson I, Hanås R, Hellenberg L, Hellgren H, Holmberg E, Hörnell H, Ivarsson SA, Johansson C, Jonsell G, Kockum K, Lindblad B, Lindh A, Ludvigsson J, Myrdal U, Neiderud J, Segnestam K, Sjöblad S, Skogsberg L, Strömberg L, Ståhle U, Thalme B, Tullus K, Tuvemo T, Wallensteen M, Westphal O, Dahlquist G, Aman J. SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients. Genes Immun. 8:518-521, 2007.
  26. Odermarsky M, Nilsson A, Lernmark A, Sjoblad S, Liuba P. Atherogenic Vascular and Lipid Phenotypes in Young Type 1 Diabetics are Associated with Diabetes High Risk HLA. Am J Physiol Heart Circ Physiol. 293:H3175-179, 2007.
  27. Eising S, Svensson J, Skogstrand K, Nilsson A, Lynch K, Andersen PS, Lernmark A, Hougaard DM, Pociot F, Norgaard-Pedersen B, Nerup J. Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study. Paediatr Perinat Epidemiol. 21:507-517, 2007.
  28. Fawwaz S, Nikamo P, Törn C, Landin-Olsson M, Lernmark A, Alarcon-Riquelme M, Kockum I; the Diabetes Incidence in Sweden Study Group. No evidence of association of the PDCD1 gene with Type 1 diabetes. Diabet Med. 24:1473-1477, 2007.
  29. Elfving M, Lindberg B, Lynch K, Ivarsson SA, Lernmark A, Hampe CS. Epitope analysis of GAD65 binding in both cord blood and at the time of clinical diagnosis of childhood type 1 diabetes. Horm Metab Res. 39:790-796, 2007.

 

2006 Back to Top

  1. Mei Q, Mundinger TO, Lernmark A, Taborsky GJ Jr. Increased galanin expression in the celiac ganglion of BB diabetic rats. Neuropeptides 40:1-10, 2006.
  2. Shaat N, Karlsson E, Lernmark A, Ivarsson S, Lynch K, Parikh H, Almgren P, Berntorp K, Groop L. Common variants in MODY genes increase the risk of gestational diabetes mellitus. Diabetologia 49:1545-51, 2006.
  3. Agardh D, Lynch K, Brundin C, Ivarsson SA, Lernmark A, Cilio CM. Reduction of tissue transglutaminase autoantibody levels by gluten-free diet is associated with changes in subsets of peripheral blood lymphocytes in children with newly diagnosed coeliac disease. Clin Exp Immunol 144:67-75, 2006.
  4. Geoffrey R, Jia S, Kwitek AE, Woodliff J, Ghosh S, Lernmark Å, Wang X, Hessner, MJ. Evidence of a functional role for Mast Cells in the development of type 1 diabetes mellitus in the BioBreeding Rat. J
    Immunol 177 (10): 7275-7286, 2006.
  5. Roach JC, Deutsch K, Li S, Siegel AF, Bekris LM, Einhaus DC, Sheridan CM, Glusman G, Hood L, Lernmark Å, Janer M. on behalf of the Swedish Childhood Diabetes Study Group and the Diabetes Incidence in Sweden Study Group. Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5- triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden. Am J Human Genet 79:614- 27,2006.
  6. Zangeneh F, Arora PS, Dyck PJ, Bekris L, Lernmark Å, Achenbach SA, Oberg AL, Rizza RA. Effects of duration of type 2 diabetes mellitus on insulin secretion. Endocr Pract 12 : 388-93, 2006.
  7. Niklasson B, Samsioe A, Blixt M, Sandler S, Sjöholm Å, Lagerquist E, Lernmark Å, Klitz W. Prenatal viral exposure followed by adult glucose intolerance in a mouse model. Diabetologia 49:2192–2199, 2006.
  8. Balasubramanyam A, Garza G, Rodriguez L, Hampe C, Gaur L, Lernmark Å, Maldonado M. Accuracy and predictive value of classification schemes for ketosis-prone diabetes mellitus (KPDM). Diabetes Care 29 :2575-2579, 2006.
  9. Hagopian WA, Lernmark A, Rewers MJ, Simell OG, She JX, Ziegler AG, Krischer JP, Akolkar B. TEDDY--The Environmental Determinants of Diabetes in the Young: an observational clinical trial. Ann N Y Acad Sci. 1079:320-326, 2006.
  10. Lernmark B, Lynch K, Lernmark Å and the DiPiS Study Group. Cord Blood Antibodies are related to stress in the mother during pregnancy. Ann NY Acad Sci 1079: 345-349, 2006.
  11. Gupta M, Graham J, McNeeny B, Zarghami M, Landin-Olsson M, Hagopian WA, Palmer J, Lernmark A, Sanjeevi CB. MHC class I chain-related gene-A is associated with IA2 and IAA but not GAD in Swedish type 1 diabetes mellitus. Ann N Y Acad Sci. 1079:229-239, 2006.
  12. Fuller J, Kwitek A, Hawkins T, Moralejo D, Lu W, Tupling T, MacMurray A, Borchardt G, Hasinoff M, Lernmark Å. Introgression of F344 rat genomic DNA and BB Rat chromosome 4 generates diabetes-resistant lymphopenic BB rats. Diabetes 55: 3351-57, 2006.
  13. Gebe JA, Unrath KA, Falk BA, Ito K, Wen L, Daniels TL, Lernmark A, Nepom GT. Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice. Clin Immunol. 121:294-304, 2006.
  14. Holm BC, Svensson J, Akesson C, Arvastsson J, Ljungberg J, Lynch K, Ivarsson SA, Lernmark A, Cilio CM for the Diabetes Prediction Study in Skane (DiPiS). Evidence for immunological priming and increased frequency of CD4+ CD25+ cord blood T cells in children born to mothers with type 1 diabetes. Clin Exp Immunol. 146 :493-502, 2006.
  15. Hall TR, Thomas JW, Padoa CJ, Torn C, Landin-Olsson M, Ortqvist E, Hampe CS. Longitudinal epitope analysis of insulin-binding antibodies in type 1 diabetes. Clin Exp Immunol. 146:9-14, 2006
  16. Gilliam LK, Jensen, RA, Yang P, Weigle DS, Greenbaum CJ, Pihoker C. Evaluation of leptin levels in subjects at risk for type 1 diabetes. J Autoimmun 26:133-7, 2006.
  17. Gilliam LK, Kohn A, Lalani T, Swanson PE, Vasko V, Francis GL, Livingston R, Pickett CA. Capecetibine therapy for refractory metastatic thyroid carcinoma – A case series. Thyroid 16:801-10, 2006.
  18. Gilliam LK and Palmer JP. How useful is autoantibody screening in adult-onset diabetes? Nat Clin Pract Endocrinol Metab 2(9):490-1, 2006.
  19. Gilliam LK and Palmer JP. LADA. Insulin 1(3):122-27, 2006.
  20. Suckow AT, Sweet IR, Van Yserloo B, Rutledge EA, Hall TR, Waldrop M, Chessler SD. Identification and characterization of a novel isoform of the vesicular gamma-aminobutyric acid transporter with glucose-regulated expression in rat islets. J Mol Endocrinol. 2006 Feb;36(1):187-99.

 

2005 Back to Top

  1. Padoa CJ, Crowther NJ, Thomas JW, Hall TR, Bekris LM, Torn C, Landin-Olsson M, Ortqvist E, Palmer JP, Lernmark Å, Hampe CS. Epitope analysis of insulin autoantibodies using recombinant Fab. Clin Exp Immunol. 2005 Jun;140(3):564-71.
  2. Sommandas V, Rutledge EA, Van Yserloo B, Fuller J, Lernmark Å, Drexhage HA. Aberrancies in the differentiation and maturation of dendritic cells from bone-marrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat. J Autoimmun. 2005 Jul 12; [Epub ahead of print]
  3. Agardh D, Cilio CM, Lethagen A, Lynch K, Leslie RD, Palmer M, Harris RA, Robertson JA, Lernmark Å. Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes. J Diabetes Complications. 2005 Jul-Aug;19(4):238-46.
  4. Larsson HE, Lynch K, Lernmark B, Nilsson A, Hansson G, Almgren P, Lernmark Å, Ivarsson SA. DiPiS Study Group. Diabetes-associated HLA genotypes affect birthweight in the general population. Diabetologia. 2005 Jul 1; [Epub ahead of print]
  5. Agardh D, Roth B, Lernmark Å, Stenberg P. Calcium activation of tissue transglutaminase in radioligand binding and enzyme-linked autoantibody immunoassays in childhood celiac disease. Clin Chim Acta. 2005 Aug;358(1-2):95-103.
  6. Sommandas V, Rutledge EA, Van Yserloo B, Fuller J, Lernmark Å, Drexhage HA. Defects in differentiation of bone marrow derived dendridic cells of the BB Rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB Rat background. J Autoimmun. 25:46-56. 2005.
  7. Agardh D, Dahlbom I, Daniels T, Lorinc E, Ivarsson SA, Lernmark A, Hansson T. Autoantibodies against soluble and immobilized human recombinant tissue transglutaminase in children with celiac disease. J Pediatr Gastroenterol Nutr. 41:322-327, 2005.
  8. Akesson K, Nystrom L, Farnkvist L, Ostman J, Lernmark A, Kockum I: Increased risk of diabetes among relatives of female insulin-treated patients diagnosed at 15-34 years of age. Diabet Med 22:1551-1557, 2005.
  9. Hawkins T, Fuller J, Olson K, Speros S, Lernmark A: DR.lyp/lyp bone marrow maintains lymphopenia and promotes diabetes in lyp/lyp but not in +/+ recipient DR.lyp BB rats. J Autoimmun 25:251-257, 2005.
  10. Valdes AM, Thomson G, Graham J, Zarghami M, McNeney B, Kockum I, Smith A, Lathrop M, Steenkiste AR, Dorman JS, Noble JA, Hansen JA, Pugliese A, Lernmark A: D6S265*15 marks a DRB1*15, DQB1*0602 haplotype associated with attenuated protection from type 1 diabetes mellitus. Diabetologia 48:2540-2543, 2005.
  11. Shaat N, Ekelund M, Lernmark A, Ivarsson S, Almgren P, Berntorp K, Groop L: Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus. Diabetologia 48:2544-2551, 2005.
  12. Bekris LM, Shephard C, Peterson M, Hoehna J, Van Yserloo B, Rutledge E, Farin F, Kavanagh TJ, Lernmark A: Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset. Autoimmunity 38:567-575, 2005.
  13. Schlosser M, Banga JP, Madec AM, Binder KA, Strebelow M, Rjasanowski I, Wassmuth R, Gilliam LK, Luo D, Hampe CS. Dynamic Changes of GAD65Ab Epitope Specificities during Progression to Type 1 Diabetes. Diabetologia. 48: 922-30 2005.
  14. Hampe CS, Wallen A, Binder KA, Schlosser M, Ziegler M, Sweet IR. Quantitative evaluation of a monoclonal antibody and its fragment as potential markers for pancreatic beta cell mass. Exp Clin Endocrinol Diabetes. 113: 381-7 2005.
  15. Waldrop MA, Sucko AT, Hall TR, Hampe CS, Marcovina SM, Chessler SD. A highly sensitive immunoassay resistant to autoantibody interference for detection of the diabetes-associated autoantigen GAD65 in blood and other biological samples. Diabetes Technol Ther. 2:207-18. 2006
  16. Raju R, Foote J, Banga JP, Hall TR, Padoa CJ, Dalakas MC, Ortqvist E, Hampe CS. Analysis of GAD65 Autoantibodies in Stiff Person Syndrome Patients. J Immunol. 2005 175:7755-62 2005
  17. Palmer JP, Hampe CS, Chiu H, Goel A, Brooks-Worrell BM Is LADA Distinct from T1DM or Just T1DM at an Older Age? Diabetes 54(suppl):S62-7 2005
  18. Pihoker C, Gilliam LK, Hampe CS, Lernmark A. Autoantibodies in Diabetes. Diabetes. 54(suppl):S52-61 2005
  19. Gilliam LK, Brooks-Worrell BM, Palmer JP, Greenbaum CJ, Pihoker C. Autoimmunity and clinical course in children with type 1, type 2, and type 1.5 diabetes. J Autoimmun 25:244-50, 2005.
  20. Sweet IR, Gilbert M, Jensen R, et al. Glucose stimulation of
    cytochrome C reduction and oxygen consumption as assessment of human islet quality.     Transplantation. Oct 27 2005;80(8):1003-1011.

 

2004 Back to Top

  1. Sweet IR, Cook DL, Lernmark Å, Greenbaum CJ, Wallen AR, Marcum ES, Stekhova S, Krohn KA. Systematic screening of potential B-cell imaging agents. Biochemical and Biophysical Research Communications. 314: 976-983, 2004.
  2. Agardh E, Gaur LK, Lernmark Å, Agardh CD. HLA-DRB1, -DQA1, -DQB1 subtypes or ACE gene polymorphisms do not seem to be risk markers for sera retinopathy in younger type 1 diabetic patients. Journal of Diabetes and Its Complications, 18:32-36, 2004.
  3. Luo D, Rogers CN, Steed, JT, Gilliam LK, Hampe CS, Lernmark Å. Development of glutamic acid decarboxylase 65 (GAD65) autoantibody assay using biotin-GAD65 fusion protein. Journal of Biotechnology, 111:97-104, 2004.
  4. Shaat N, Ekelund M, Lernmark Å, Ivarsson S, Nilsson A, Perfekt R, Berntorp R, Groop L. Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus. Diabetologia, 47: 878-884, 2004.
  5. Agardh D, Carlsson A, Lynch K, Axelsson I, Lernmark Å, Ivarsson SA. Using radiological-bining assays to measure tissue transglutaminase autoantibodies in young children. Acta Paediatr, 93: 1046-1051, 2004.
  6. Luo D, Gilliam LK, Greenbaum C, Bekris L, Hampe CS, Daniels T, Richter W, Marcovina SM, Rolandsson O, Landin-Olsson M, Kockum I, Lernmark Å. Conformation-dependent GAD65 autoantibodies in diabetes. Diabetologia, 47: 1581-1591, 2004.
  7. Michalkiewicz M, Michalkiewicz T, Ettinger RA, Rutledge EA, Fuller JM, Moralejo DH, Van Yserloo B, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A. Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat. Physiol Genomics 19:228-232, 2004
  8. Padmos RC, Bekris L, Knijff EM, Tiemeier H, Kupka RW, Cohen D, Nolen WA, Lernmark A, Drexhage HA. A high prevalence of organ-specific autoimmunity in patients with bipolar disorder. Biol Psychiatry 56:476-482., 2004
  9. Maioli M, Alejandro E, Tonolo G, Gilliam LK, Bekris L, Hampe CS, Obinu DA, Manconi A, Puddu L, Lynch K, Lernmark A. Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes. J Clin Endocrinol Metab 89:5675-5682., 2004
  10. Hessner MJ, Wang X, Meyer L, Geoffrey R, Jia S, Fuller J, Lernmark A, Ghosh S. Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat. J Immunol 173:6993-7002, 2004
  11. Sweet IR, Cook DL, Lernmark A, Greenbaum CJ, Krohn KA. Non-invasive imaging of beta cell mass: a quantitative analysis. Diabetes Technol Ther 6:652-659, 2004

 
 

2003 Back to Top

  1. Agardh D., Borulf S, Lernmark Å, and Ivarsson SA. Tissue transglutaminase isotypes in children with untreated and treated celiac disease. J. Pediatric Gastroenterology & Nutrition 36:77-82, 2002.
  2. Elfving AM, Lindberg BA, Landin-Olsson M, Hampe CS, Hammerle LP, Lernmark Å, Ivarsson S-A. Islet cell autoantibodies in cord blood from children with blood group incompatibility or hyperbilirubinemia. Autoimmunity 36:111-125, 2003.
  3. Rolandsson O, Hägg E, Janer M, Rutledge E, Gaur LK, Nilsson M, Hallmans G, Lernmark Å. High GAD65 autoantibody levels in nondiabetic adults are associated with HLA but not with CTLA-4 or INS VNTR. J. Intern. Med 253:447-53, 2003.
  4. Gupta M, Nikitina-Zake L, Zarghami M, Landin-Olsson M, Kockum I, Lernmark Å and Sanjeevi CB. Association between the transmembrane region polymorphism of MHC Class I chain related gene-A and type 1 diabetes mellitus in Sweden. Human Immunology 64:553-561, 2003.
  5. Niklasson B, Heller KE, Schoenecker B, Bildsoe M, Daniels T, Hampe CS, Widlund P, Simonson WT, Schaefer JB, Rutledge E, Bekris L, Lindberg AM, Johansson S, Örtqvist E, Persson B and Lernmark Å. Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel Ljungan virus. Exp. Diabetes Res.4:35-44, 2003.
  6. Luo D, Rogers CN, Hampe CS, Lernmark Å. Molecular engineering of biotin-glutamic acid decarboxylase 65 fusion protein (Biotin-GAD65) for non-radioactive GAD65 antibody assay. J Biotechnol, 103(3):249-55, 2003.
  7. Elfving AM, Lindberg BA, Nystrom L, Sundkvist G, Lernmark Å, Ivarsson SA. Islet Autoantibodies in Cord Blood from Patients who developed Type 1 Diabetes Mellitus at 15-30 Years of Age. Autoimmunity 4:227-231, 2003.
  8. Moralejo DH, Park HA, Speros S, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark Å. Genetic Dissection of Lymphopenia from Autoimmunity by Introgression of Mutated Ian5 gene onto the F344 Rat. J Autoimmunity 21:315-324, 2003.
  9. Maldonado M, Hampe CS, Amico SD, Lyer D, Lakshmi KG, Hammerle LP, Bolgiano D, Rodriguez L, Rajan A, Lernmark Å, Balasubramanyam A. Novel syndromes of ketosis-prone diabetes: classification, prospective analysis and outcomes. Journal of Clin Endocrinology & Metab 88:5090-5098, 2003.
  10. Boutin P, Dina C, Vasseur F, Dubois S, Corset L, Séron K, Bekris L, Cabellon J, Neve B, Vasseur-Delannoy V, Chikri M, Charles MA, Clement K, Lernmark Å, Frougel P. GAD2 on chromosome 10p12 is a candidate gene for human obesity. PLOS Biology 1: 1-7, 2003.
  11. Niklasson B, Hörnfeldt B, Nyholm E, Niedrig M, Donoso-Mantke O, Gelderblom HR, Lernmark Å. Type 1 diabetes in Swedish bank voles (Clethrionomys glareolus): signs of disease in both colonized and in wild cyclic populations at peak density.Ann NY Acad Aci 1005:170-5, 2003.
  12. Carrol AD, Scampavia L, Luo D, Lernmark Å, Ruzicka J. Bead injection ELISA for the determination of antibodies implicated in type 1 diabetes mellitus. Analyst, 128(9):1157-62, 2003.
  13. Kobayashi T, Tanaka S, Okubo M, Nakanishi K and Murase T, Lernmark Å. Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive and acute-onset type 1 diabetes. J Clin Endocrinol Metab. 88(10):4768-75, 2003.
  14. Mundinger TO, Mei Q, Figlewicz DP, Lernmark Å, Taborsky Jr GJ. Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: an effect of early sympathetic islet neuropathy (eSIN). Am J Physiol Endocrinol Metab. 285:E1047-54, 2003.
  15. Genuth S, Alberti KG, Bennett P, Buse J, Defronzo R, Kahn R, Kitzmiller J, Knowler WC, Lebovitz H, Lernmark Å, Nathan D, Palmer J, Rizza R, Saudek C, Shaw J, Steffes M, Stern M, Tuomilehto J, Zimmet P. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care, 26(11):3160-7, 2003.

2002 Back to Top

  1. Hampe CS, Hammerle LP, Bekris L, Ortqvist E, Persson B and Lernmark Å. Stable GAD6 autoantibody epitope patterns in type 1 diabetes children five years after onset. J Autoimmunity 18:49-53, 2002.
  2. Agardh D, Nilsson A, Carlsson A, Kockum I, Lernmark Å and Ivarson S-A. Tissue transglutaminase autoantibodies and human leucocyte antigen in down syndrome patient with coeliac disease. Acta Paediatr 9:34-38, 2002.
  3. Clark L, Greenbaum C, Jiang J, Lenmark Å, and Ochs H. The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats. FEMS 32:205-209, 2002.
  4. Maioli M, Tonolo G, Bekris L, Cirillo R, Schranz D, Cossu E, Ciccarese M, Lernmark Å. GAD65 but not IA-2 autoantibodies are common in siblings of Sardinian type 2 diabetic families. Diabetes Res. Clin. Practice 56:41-47, 2002.
  5. Graham J, Hagopian WA, Kockum I, Li LS, Sanjeevi CB, Lowe RM, Schaefer JB, Zarghami M, Day HL, Landin-Olsson M, Palmer JP, Janer-Villanueva M, Hood L, Sundkvist G, Lernmark Å, Breslow N, Dahlquist G, for the *Swedish Childhood Diabetes Study Group, and Göran Blohmé,10 for the *Diabetes Incidence in Sweden Study (DISS) Group. Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes. Diabetes 51:1346-1355, 2002.
  6. Mohatt J, Gilliam LK, Bekris L, Ebbeson S, Lernmark Å. Type 1 diabetes-related autoantibodies are rare in Alaskan native populations. Int. J. Circumpolar Health 61:21-31, 2002.
  7. Simonson W, Ramanathan S, Bieg S, Poussier P. and Lernmark Å. Protein-free diets do not protect high incidence diabetes-prone BB rats from diabetes. Metabolism Clin & Exp.51:569-574, 2002
  8. Gaur LK, Kennedy E, Nitta Y, Nepom GT, Nelson KA, Allen M and Lernmark Å. Kennedy E, Nitta Y, Nepom GT, Nelson KA, Allen M. and Lernmark Å. Induction of donor-specific tolerance to islet allografts in nonhuman primates. Ann. N.Y. Acad. Sci. 958:194-198, 2002.
  9. Gaur LK, Nitta Y, Kennedy E, Lernmark Å, Nelson KA, Allen M. and Nepom GT. Induction of islet allotolerance in nonhuman primates. Ann. N.Y. Acad. Sci. 958:199-203, 2002.
  10. Sanjeevi CB, Landin-Olsson M, Kockum I, Dahlquist G, Lernmark Å. The combination of several polymorphic amino acid residues in the DQ_ and DQ_ chains form a domain structure pattern and are associated with insulin-dependent diabetes mellitus. Ann. N.Y. Acad. Sci. 958:362-375, 2002.
  11. Sweet IR, Cook DL, Wiseman RW, Greenbaum CJ, Lernmark Å, Matsumoto S, Teague JC and Krohn KA. Dynamic perifusion to maintain and assess isolated pancreatic islets. Diab. Tech. & Therap. 4:67-76, 2002.
  12. MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, Gohlke P, Speros SS, Snyder B, Schaefer J, Bieg S, Jiang J, Ettinger RA, Fuller J, Daniels TL, Pettersson A, Orlebeke K, Birren B, Jacob HJ, Lander ES and Lernmark Å. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel Immune-Associated Nucleotide (Ian) Related Gene. Genome Research 12:1029-1039, 2002.
  13. Sims TJ, Lernmark Å, Mancl LA, Schifferle RE, Page RC, Persson GR. Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis. J. Clin. Periodontology. 29:550-560, 2002.
  14. Hampe CS, Kockum I, Landin-Olsson M, Törn C, Örtqvist E, Persson O, Rolandsson O, Palmer JP and Lernmark Å. GAD65 antibody epitope patterns of patients with Type 1.5 differ from that of Type 1 diabetes patients. Diabetes Care 25:1481-1482, 2002
  15. Mei Q, Mundinger TO, Lernmark Å, Taborsky GJ. Jr. Early, selective, and marked loss of sympathetic nerves from the islets of biobreeder diabetic rats. Diabetes 51:2997-3002, 2002.
  16. Rolandsson O, Haney MF, Hägg E, Biber B and Lernmark Å. Streptozotocin induced diabetes in minipig: A case report of a possible model for type 1 diabetes? Autoimmunity 35:261-264, 2002.
  17. Plesner A, Greenbaum CJ, Gaur LK, Ernst RK and Lernmark Å. Macrophages from high risk HLA DQB1*0201/0302 type 1 diabetes patients are hypersensitive to lipopolysaccharide stimulation. Scand. J. Immunol. 56:522-529, 2002.
  18. Zarghami M, Bonnevie-Nielsen V., Tobias R, Engel M, Graham J, McNeney B, Schaefer J, Lernmark Å. Studies on the association between 2'5'-oligoadenylate synthetase and type 1 diabetes. 13th International HLA Workshop and Conference. HLA 2002.
  19. Gilliam LK, Lobenhofer EK, Greer PK, Scearce RM, Cirisano FD, Marks JR, and Hale LP: BRCA2 monoclonal antibodies react with differentiating epithelium. Hybrid Hybridomics 21:261-9, 2002.

 

2001 Back to Top

  1. Hampe CS, Lundgren P, Daniels TL, Hammerle LP, Marcovina SM and Lernmark Å. A novel monoclonal antibody specific for the N-terminal end of GAD65. J Neuroimmum. 113:63-71, 2001.
  2. Barry SC, Ramesh N, Lejnieks DV, Simonson WT, Kemper L, Lernmark Å, Osborne WRA. Glucose-regulated insulin expression in diabetic rats. Human Gene Therapy 12:13-139, 2001.
  3. Plesner A, Greenbaum CJ. and Lernmark Å. Low serum conditions for in vitro generation of human macrophages with macrophage-colony stimulating factor. J. Immunol Methods 249:53-61, 2001.
  4. Hampe CS, Hammerle LP, Falorni A, Robertson J and Lernmark Å. Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding. FEBS Letters 488:185-189, 2001.
  5. Torn C, Landin-Olsson M, Lernmark Å, Schersten B, Ostman J, Arnqvist HJ, Bjork E, Blohme G, Bolinder J, Eriksson J, Littorin B, Nystrom L, and Sundkvist G. Combinations of Beta Cell Specific Autoantibodies at Diagnosis of Diabetes in Young Adults Reflects Different Courses of Beta Cell Damage. Autoimmunity 33:115-120, 2001.
  6. Rolandsson O, Hagg E, Nilsson M, Hallmans G, Mincheva-Nilsson L, Lernmark Å. Prediction of diabetes with body mass index, oral glucose tolerance test and islet cell autoantibodies in a regional population. J. Int. Med. 249:279-288, 2001.
  7. Novak EJ, Liu AW, Gebe JA, Galk BA, Nepom GT, Koelle DM and Kwok WW. Tetramer-Guided Epitope Mapping: Rapid Identification and Characterization of Immunodominant CD4+ T Cell Epitopes from Complex Antigens. J. Immunol 166:6665-6670, 2001.
  8. Novak EJ, Masewicz1 SA, Liu AW, Lernmark Å, Kwok WW and Nepom GT. Activated human epitope-specific T cells identified by class II tetramers reside within a CD4 high, proliferating subset. Int Immun. 13:799-806, 2001.
  9. Sims TJ, Lernmark Å, Smith T, Page RC, Persson GR. Treatment outcome for IDDM patients in relation to glutamic acid decarboxylase autoantibodies and serum IgG to periodontal pathogens. J. Periodont. 28:550-557, 2001.
  10. Agardh D, Nilsson A, Tumi T, Lindberg B, Carlsson A, Lernmark Å, and Ivarsson S. Prediction of silent celiac disease at diagnosis of childhood type 1 diabetes by tissue transglutaminase autoantibodies and HLA. Pediatric Diabetes 2:58, 2001.
  11. Gaur LK, Nepom G, Lernmark Å. Low-dose streptozotocin induces sustained hyperglycemia in Macaque nemestrina. J. Atoimmunity33103-14, 2001.
  12. Uibo T, Sullivan EP, Uibo O, Lernmark Å, Salur L, Kivik T, Mandel M. Comparison of the prevalence of glutamic acid decarboxylase (GAD65) and gliadin antibodies (AGA) in a randomly selected adult Estonian population. Horm. Metab. Res. 33:564-7, 2001.
  13. Plesner A, Hampe CS, Daniels TL, Hammerle LP, and Lernmark Å. Preservation of enzyme activity and antigenicity after mutagenesis of the membrane anchoring domain of GAD65. Autoimmunity 34:221-230, 2001.

 

2000 Back to Top

  1. Chessler S, and Lernmark Å. Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues. J. Biol. Chem. 7:5188-5192, 2000.
  2. Bieg S, Simonson WT, Elefson K, Lernmark Å. Rel B is an early marker of autoimmune islet inflammation in the BioBreeding BB rat. Pancreas 20:47-54, 2000.
  3. Schranz DB, Bekris L, Landin-Olsson M, Törn C, Nilang A, Toll Å, Sjöström J, Grönlund H and Lernmark Å for the Diabetes Incidence Study in Sweden (DISS) Newly diagnosed latent autoimmune diabetes in adults (LADA) is associated with low level glutamate decarboxylase (GAD65) and IA-2Ab autoantibodies. Hormone & Metab. Res. 32-133-138, 2000.
  4. Östman J, Landin-Olsson M, Törn C, Palmer J, Lernmark Å, Arnqvist H, Björk E, Bolinder J, Blohmé G, Eriksson J, Littorin B, Nyström L, Scherstén B, Sundkvist G, Wibell L. Ketoacidosis in young adults is not related to the islet antibodies at the diagnosis of Type 1 diabetes mellitus--a nationwide study. Diabet. Med. 17:269-4, 2000.
  5. Marcovina SM, Landin-Olsson M, Essen-Möller A, Palmer JP and Lernmark Å. Evaluation of a novel radioimmunoassay using 125I-labeled human recombinant GAD65 for the determination of glutamic acid decarboxylase (GAD65) autoantibodies. Int. J. Clin. Lab. Res. 30:21-26, 2000.
  6. Novak EJ, Ortqvist E, Nord E, Edwall L, Hampe CS, Bekris L, Persson BE and Lenmark Å. Stability of disease-associated antibody titers in pregnant women with type 1 diabetes with or without residual beta-cell function. Diabetes Care,23:1019-1021, 2000.
  7. Hoeldtke RD, Bryner KD, Hobbs GR, Horvath GG, Riggs JE, Christie I, Ganser G, Marcovina SM, Lernmark Å. Antibodies to glutamic acid decarboxylase and peripheral nerve function in type 1 diabetes. J Clin Endocrinol Metab. 3297-308, 2000.
  8. Mire-Sluis AT, Das RG, Lernmark Å. and Participants of the study. The World Health Organization International Collaborative Study for Islet Cell Antibodies. Diabetologia 43:1282-1292, 2000.
  9. Reijonen H, Daniels TL, Lernmark Å, Nepom GT.GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65. Diabetes 49:1621-6, 2000.
  10. Lowe RM, Graham J, Sund G, Kockum I, Landin-Olsson M, Schaefer JB, Törn C, Lernmark Å, Dahlquist G, for the Swedish Childhood Diabetes Study Group and Blohmé G. for the Diabetes Incidence in Sweden Study Group. The length of the CTLA-4 microsatellite (AT)n-repeat affects the risk for Type 1 diabetes. Autoimmunity
  11. Törn C, Landin-Olsson M, östman J, Scherstén B, Arnqvist H, Blohmé G, Björk E, Bolinder J, Eriksson J, Littorin B, Nyström L, Sundkvist G, Lernmark Å. Glutamic acid decarboxylase antibodies (GADA) is the most important factor for prediction of insulin therapy within three years in young adult diabetic patients not classified as type 1 diabetes on clinical grounds. Diabetes/Metab Res and Rev 16:442-447, 2000.
  12. Törn C, Landin-Olsson M, Lernmark Å , Palmer J, Arnqvist HJ, Blohmé G, Lithner F, Littorin B, Nyström L, Scherstén B, Sundkvist G, Wibell L. and Östman J. Prognostic factors for the course of beta cell function in autoimmune diabetes. J Clin Endo Metab 85:4619-4623, 2000.
  13. Hampe CS, Hammerle LP, Örtqvist E, Kockum I, Rolandsson O, Landin-Olsson M, Törn C, Persson B and Lernmark Å. Recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different GAD antibody-positive phenotypes. JCEM 85:4671-4679, 2000.

 

1999 Back to Top

  1. Lee ES, Jiang J, Sund GC, Simonson WT, Graham J, Dietsch G, Schimpf B, Bieg S, Peterman G and Lernmark Å. Recombinant human platelet activating factor acetylhydrolase reduces the frequency of diabetes in the diabetes prone BB rat. Diabetes.48:43-49, 1999.
  2. Hampe CS, Örtqvist E, Rolandsson O, Landin-Olsson M, Törn C, Agren Å, Persson B, Schranz DB, Lernmark Å. Species specific autoantibodies in Type 1 diabetes. J. Clin Endo. Metab.84:643-648, 1999.
  3. Roep BO, Stobbe I, Duinkerken G, van Rood JJ, Lernmark Å, Keymeulen B, Pipeleers D, Claas FHJ and de Vries RRP. Auto- and alloimmune reactivity to human islet allografts transplanted to insulin dependent diabetes mellitus patients. Diabetes 48:484-490, 1999.
  4. Lindberg B, Ivarsson S-A, Landin-Olsson M, Sundkvist G, Svanberg L, Lernmark Å. Islet autoantibodies in cord blood from children who developed Type 1 (insulin dependent) diabetes before 15 years of age. Diabetologia 42:181-187, 1999.
  5. Nikoshkov A, Falorni A, Lajic S, Laureti S, Wedell A, Lernmark Å and Luthman H. A conformation-dependendent epitope in Addison’s and other endocrinological autoimmune diseases maps to the carboxy-terminal functional domain of human steroid 21-hydroxylase. J. Immunology 162:2422-2426, 1999.
  6. Landin-Olsson M, Arnqvist HJ, Blohmé G, Littorin B, Lithner F,Nyström L, Scherstén B, Sundkvist G, Wibell L, Östman J, Lernmark Å. Appearance of islet cell autoantibodies after clinical diagnosis of diabetes mellitus. Autoimmunity 29:57-63, 1999.
  7. Hao W, Daniels T, Pipeleers D, Smismans A, Reijonen H, Nepom G and Lernmark Å. Radio-immunoassay for glutamic acid decarboxylase-65. Diabetes Technology and Therapeutics 1:13-20, 1999
  8. Littorin B, Sundkvist G, Hagopian W, Landin-Olsson M, Lernmark Å, östman J, Arnqvist HJ, Blohmé G, Bolinder J, Eriksson JW, Lithner F, Schersten B, Wibell L. Islet cell and glutamic acid decarboxylase antibodies present at diagnosis of diabetes predict the need for insulin treatment. Diabetes Care 22:409,412, 1999.
  9. Rolandsson O, Hägg E, Hampe C, Sullivan, Jr. EP, Nilsson M, Jansson G, Hallmans G, Lernmark Å. Levels of glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies in the general population are related to glucose intolerance and body mass index. Diabetologia 42:555-559, 1999.
  10. Graham J, Kockum I, Sanjeevi CB, Landin-Olsson M, Nyström L, Sundkvist G, Arnqvist, Blohme G, Lithner F, Littorin B, Scherstén B, Wibell L, Östman J, Lernmark Å, Breslow N, Dahlquist G, and the Swedish Childhood Diabetes Study Group. Negative association between type 1 diabetes and HLA DQB1*0602-DQA1*0102 is attenuated with age at onset. Eur. J. of Immunogentics.26:117-127:1999.
  11. Bieg, S. Differential expression of p95 vav in primary lymphoid tissue of BB rats congenic for the lymphopenia gene. Autoimmunity30:37-42, 1999.
  12. Hao W, Davis C, Hirsch IB, Eng LJ, Daniels W, and Lernmark Å. Plasmapheresis and immunosuppression in Stiff-man syndrome with type 1 diabetes: A two year study. J. Neurol.246:731-735, 1999
  13. Moore J, Gold DP, Dreskin SC, Lernmark Å, and Bellgrau D. A diabetogenic gene prevents T cells from receiving costimulatory signals. Cellular Immunology194:90-97, 1999.
  14. Lindberg B, Ahlfors K, Carlsson A, Ericsson U-B, Landin-Olsson M, Lernmark Å, Ludvigsson J, Sundkvist G, Ivarsson S-A. Previous exposure to measles, mumps, and rubella-but not vaccination during adolescence-correlates to the prevalence of pancreatic and thyroid autoantibodies. Pediatrics 104:12, 1999.
  15. Zavosh A, Schaefer J, Ferrel A, and Figlewicz DP. Desipramine treatment decreases 3H-nisoxetine binding and norepinephrine transporter mRNA in SK-N-SHSY5Y cells. Brain Res. Bull. 49:291-295, 1999.
  16. Lindberg B, Ivarsson S-A., Lernmark Å. Influence of heredity on the appearance of islet autoantibodies in cordblood from children developing Type 1 diabetes before 15 years of age. Diabetologia1 42:896, 1999.
  17. Lernmark Å. Type 1 Diabetes. Clin. Chem. 45:1331-1338, 1999.
  18. Klaff LS, Koike G, Jiang J, Wang Y, Bieg S, Petersson A, Lander E, Jacob H and Lernmark Å. BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2. Mammalian Genome 10:883-887, 1999.
  19. Bieg S, Hanlon C, Hampe CS, Benjamin D, and Mahoney CP. GAD65 and insulin B chain peptide (9-23) are not primary autoantigens in the type 1 diabetes syndrome of the BB rat. Autoimmunity31:15-24, 1999.
  20. Hao W, Davis C, Daniels T, Hampe CS and Lernmark Å. Epitope-specific glutamic acid decarboxylase-65 autoantibodies in intravenous immunoglobulin preparations. Transfusion Medicine 9:307-310, 1999.
  21. Kockum I, Sanjeevi CB, Eastman S, Landin-Olsson M, Dahlquist G, Lernmark Å and co-authors. Complex interaction between HLA DR and DQ in conferring risk for childhood type 1 diabetes. Eur. J. Immunogenetics 26:361-372, 1999.
  22. Hampe CS, Örtqvist E, Persson B, Schranz DB, Lernmark Å. Glutamate decarboxylase (GAD) autoantibody epitope shift during the first year of type 1 diabetes. Horm. Metab. Res. 31:553-557, 1999.
  23. Undlien DE, Kockum I, Ronningen KS, Lowe R, Sanjeevi CB, Graham J, Lie BA, Akselsen HE, Lernmark Å, Thorsby E. HLA associations in type 1 diabetes among patients not carrying high-risk DR3-DQ2 or DR4-DQ8 haplotypes. Tissue Antigens54:543-551, 1999.
  24. Bieg S, Simonson WT, Elefson K, Lernmark Å. Rel B is an early marker of autoimmune islet inflammation in the BioBreeding BB rat. Pancreas 20:47-54, 1999.
  25. Lindberg B, Carlsson A, Ericsson U-B, Kockum K, Lernmark Å, Landin-Olsson M, Sundkvist G, Ivarsson S-A. Prevalence of beta-cell and thyroid autoantibody positivity in school children during three years follow-up. Autoimmunity 31:175-85, 1999.

 

1998 Back to Top

  1. Sanjeevi CB, Hagopian WA, Landin-Olsson M, Kockum I, Woo W, Palmer JP, Lernmark Å, Dahlquist G. Association between autoantibody marker and subtypes of DR4 and DR4-DQ in Swedish children with insulin-dependent diabetes reveals closer association of tyrosine pyrophosphatase autoimmunity with DR4 than DQ8. Tissue Antigens 51:281-286, 1998.
  2. Bieg S, Koike G, Jiang J, Klaff L, Pettersson A, MacMurray AJ, Jacob HJ, Lander ES. Genetic isolation of iddm 1 on Chromosome 4 in the BioBreeding (BB ) rat. Mammalian Genome 9:324-326, 1998.
  3. Schranz DB, Bekris L, Landin-Olsson M, Törn C, Niläng A, Toll Å, Grönlund H, Toivola B, Lernmark Å and the Diabetes Incidence Study in Sweden (DISS). A simple and rapid microSepharose assay for gad65 and ICA512 autoantibodies in diabetes. J. Immunol. Methods 213:87-97, 1998.
  4. Strömberg S, Crock P, Lernmark Å and Hulting AL. Pituitary autoantibodies in patients with hypopituitarism and their relatives. J. Endocrinology 157:475-480, 1998.
  5. Agardh D, Agardh E, Landin-Olsson M, Gaur LK, Agardh C-D, Lernmark Å. Inverse relationship between GAD65 antibody levels and severe retinopathy in type 1 diabetic patients. Diab Res. Clin. Prac. 40:9-14, 1998.
  6. Hirsch IB, D'Alessio D, Eng L, Davis C, Lernmark Å, Chait A. Severe insulin resistance in a patient with type 1 diabetes and stiff-man syndrome treated with insulin lispro. Diabetes Res. and Clin. Pract. 41:197-202, 1998.
  7. Laureti S, Aubourg P, Calcinaro F, Rocchiccioli F, Casucci G, Angeletti G, Brunetti P, Lernmark Å, Santeusanio F, Falorni A. Etiologic diagnosis of primary adrenal insufficiency using an original flow-chart of immune and biochemical markers. J.C.E.M. 83:3163-3168, 1998.
  8. Verge CF, Stenger D, Bonifacio E, Colman PG, Pilcher C, Bingley PJ, Eisenbarth GS and participating laboratories. Combined use of autoantibodies (IA-2ab, GADab, IAA, ICA) in Type 1 diabetes: Combinatorial islet autoantibody workshop. Diabetes 47:1857-1866, 1998.

 

1997 Back to Top

  1. Sanjeevi CB, DeWeese C, Landin-Olsson M, Kockum I, Dahlquist G, Lernmark Å and Lybrand TP. Analysis of critical residues of HLA-DQ6 molecules in insulin-dependent diabetes mellitus. Tissue Antigen 50:61-65, 1997.
  2. Bieg S, Möller C, Olsson T, and Lernmark Å. The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats. Diabetologia 40:786-790, 1997.
  3. Lotfi K, Sund G, Lowe R, Graham J, Landin-Olsson M, Kockum I, Deeb S, Lernmark Å and the Diabetes Incidence Study in Sweden (DISS). The b cell glucokinase promoter variant is an unlikely risk factor for diabetes. Diabetologia 40:959-962, 1997.
  4. Vandewalle CL, Falorni A, Lernmark Å, Goubert P, Dorchy H, Coucke W, Semakula C, Van derAuwera B, Kaufman L, Schuit FC, Pipeleers DG, Gorus FK, and the Belgian Diabetes Registry. Associations of GAD65- and IA-2-autoantibodies with genetic risk markers in new-onset IDDM patients and their siblings. Diabetes Care 20:1547-1552, 1997.
  5. Örtqvist E, Falorni A, Scheynius A, Persson B, Lernmark Å. Age governs gender-dependent islet cell autoreactivity and predicts the clinical course in childhood IDDM. Acta Paediatrica 86:1166-1171, 1997.
  6. Hoeldtke RD, Bryner KD, Horvath GTG, Byerly MR, Hobbs GR, Marcovina SM and Lernmark Å. Antibodies to GAD and glutamic control in recent onset IDDM. Diabetes Care 20:1900-03, 1997.
  7. Dotta F, Falorni A, Tiberti C, Dionisi S, Anastasi E, Torresi P, Lernmark Å, and Di Mario U. Autoantibodies to the GM2-1 islet ganglioside and to GAD-65 at Type 1 diabetes onset. J. Autoimmunity 10:585-588, 1997.
  8. Ivarsson SA, Ackefors M, Carlsson A, Ekberg G, Falorni A, Kockum I, Landin-Olsson M, Lernmark Å, Lindberg B, Sundkvist G, and Svanberg L. Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring. Autoimmunity 26:261-269, 1997.

 

1996 Back to Top

  1. Hallengren B, Falorni A, Landin-Olsson M, Lernmark Å, Papadopoulos KI, and Sundkvist G. Islet cell and glutamic acid decarboxylase antibodies in hyperthyroid patients: at diagnosis and following treatment. J .Intern. Med. 239:63-68, 1996.
  2. Kasuga A, Maruyama T, Ozawa Y, Takei I, Falorni A, Lernmark Å, and Saruta T. Antibody to the Mr 65,000 isoform of glutamic acid decarboxylase are detected in non-insulin-dependent diabetes in Japanese. J. Autoimmunity 9:105-111, 1996.
  3. Sanjeevi CB, Höök P, Landin-Olsson M, Kockum I, Dahlquist G, Lybrand TP and Lernmark Å. DR4 subtypes and their molecular properties in a population based study of Swedish childhood diabetes. Tissue Antigen 47:275-283, 1996.
  4. Tuomi T, Björses P, Falorni A, Partanen J, Perheentupa J, Lernmark Å, Miettinen A. Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with Autoimmune polyendocrine syndrome type I. J. Clin Endo Metab, 81:1488-1494, 1996.
  5. Falorni A, Ackefors M, Carlberg C, Daniels T, Persson B, Robertson J, and Lernmark Å. Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM. Diabetologia 39:1091-1098, 1996.
  6. Graham J, Kockum I, Breslow N, Lernmark Å, and Holmberg E. A comparison of three statistical models for IDDM associations with HLA. Tissue Antigens 48:1-14, 1996.
  7. Kasuga A, Falorni A, Maruyama T, Ozawa Y., Grubin CE, Takei I, Saruta T, Scheynius A, and Lernmark Å. HLA class II is associated with both frequency and persistence of glutamic acid decarboxylase Mr 65,000 autoantibodies in Japanese insulin-dependent diabetes mellitus. ActaDiabetologica 33:108-113, 1996.
  8. Kobayashi T, Yoshitomo O, Katagiri H, Falorni A, Kasuga A, Takei I, Nakanishi K, Murase T, Kosaka K, and Lernmark Å. Association between HLA and islet cell antibodies in diabetic patients with mitochondrial DNA mutation at base pair 3243. Diabetologia 39:1196-1200, 1996.
  9. Agardh D, Gaur LK, Agardh E, Landin-Olsson M, Agardh, Lernmark Å. HLA-DQB1*0201/0302 is associated with severe retinopathy in patients with IDDM. Diabetologia 39:1313-1317, 1996.
  10. Sanjeevi CB, Hjelmström P, Hallmans G, Wiklund F, Lenner P, Ångstrom T, Dillner J and Lernmark Å. Different HLA-DR-DQ haplotypes are associated with cervical intra epithelial neoplasia among human papilloma virus type 16 seropositive and seronegative Swedish women. Int. J. Cancer, 68:409-414, 1996.
  11. Wicker LS, Chen SL, Nepom GT, Elliott JF, Freed DC, Bansal A, Zheng S, Herman A, Lernmark Å, Zaller DM, Peterson LB, Rothbard JB, Cummings R, and Whiteley PJ. Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the Type 1 diabetes-associated human MHC Class II allele, DRB1*0401. J. Clin. Invest. 98:2597-2603, 1996.

 

1995 Back to Top

  1. Pollema CH, Lernmark Å and Ruzicka J. Flow injection fluorescence microscopy applied to a rapid cell surface immunoassay. Cytometry 19:70-76, 1995.
  2. Sanjeevi CB, Lybrand, TP, DeWeese C, Landin-Olsson M, Kockum I, Dahlquist G, Sundkvist G, Stenger D, Lernmark Å. Polymorphic amino acid variations in HLA-DQ are associated with systematic physical property changes and occurrence of insulin-dependent diabetes mellitus. Diabetes 44:125-131, 1995.
  3. Li L, Jiang J, Hagopian WA, Karlsen AE, Skelly M, Baskin D and Lernmark Å. Differential detection of rat islet and brain glutamic acid decarboxylase (GAD) isoforms using sequence-specific peptide antibodies. J .Histochem. Cytochem . 43:53-59, 1995.
  4. Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, Koike G, Kren V, Kurtz T, Lernmark Å, Levan G, Mao Y, Pettersson A, Pravenec M, Simon JS, Szpirer C, Szpirer J, Trolliet MR, Winer ES and Lander ES. A genetic linkage map of the laboratory rat. Nature Genetics 9:63-69, 1995.
  5. Dirkx, R., Jr., Thomas, A., Li, L., Lernmark, Å, Sherwin, R.S., De Camilli, P. and Solimena, M. Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase. J. Biol. Chem. 270:2241-2246, 1995.
  6. Lernmark, Å., Klöppel, G., Stenger, D., Vathanaprida, C., Fält, K., Landin-Olsson, M., Baskin, D.G., Palmer, J.P., Gown, A.M., Petersen, J.S., Li, L., Edenvall, H. and Mauseth, R.S. Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus. Virchows Archives 425:631-640, 1995.
  7. Gottsäter A, Landin-Olsson M, Lernmark Å, Fernlund P, Sundkvist G and Hagopian WA. Glutamate decarboxylase antibody levels predict rate of b-cell decline in adult-onset diabetes. Diabetes Res. Clin. Practice 27:133-140, 1995.
  8. Hagopian WA, Sanjeevi CB, Kockum I, Landin-Olsson M, Karlsen AE, Sundkvist G, Dahlquist G, Palmer J, Lernmark Å. Glutamate decarboxylase-, insulin- and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J. Clin. Invest. 95:1505-1511, 1995.
  9. Vandewalle CL, Falorni A, Svanholm S, Lernmark Å, Pipeleers DG, Gorus FK and The Belgian Diabetes Registry. High diagnostic sensitivity of glutamate decarboxylase autoantibodies in IDDM with clinical onset between age 20 and 40 years. J. Clin. Endocrinol. Metab. 80:846-851, 1995.
  10. Huang X, Yuan J, Goddard A, Foulis A, James R, Lernmark Å, Pujol-Borrel R, Rabinovitch A, Somoza N, and Stewart TA. Interferon expression in the pancreases of patients with type 1 diabetes. Diabetes. 44:658-664, 1995.
  11. Sanjeevi CB, Landin-Olsson M, Kockum I, Dahlquist G, and Lernmark Å. Effects of the second HLA-DQ haplotype on the association with childhood insulin dependent diabetes mellitus. Tissue Antigens 45:148-152, 1995.
  12. Pettersson A, Winder ES, Weksler-Zangen S, Lernmark Å, and Jacob HJ. Predictability of heterozygosity scores and polymorphism information content values for rat genetic markers. Mammalian Genomics 6:512-520, 1995.
  13. Falorni A, Nikoshkov A, Laureti S., Grenback E, Hulting A-L, Casucci G, Santeusanio F, Brunetti P, Luthman H, and Lernmark Å. High diagnostic accuracy for idiopathic Addison's disease with a sensitive radiobinding assay for autoantibodies against recombinant human 21-hydroxylase. J. Clin. Endo. Metab. 80:2752-2755, 1995.
  14. Falorni A, Örtqvist E, Persson B, and Lernmark Å. Radioimmunoassays for glutamic acid decarboxylase (GAD65) and GAD65 autoantibodies using 35S or 3H recombinant human ligands. J. Immunol. Meth., 186:89-99, 1995.
  15. Yu L, Chase HP, Falorni A, Rewers M, Lernmark Å, and Eisenbarth GS. Sexual dimorphism in transmission to offspring of expression of islet autoantibodies. Diabetologia 38:1353-1357, 1995
  16. Pettersson A, Wilson D, Daniels T, Tobin S, Jacob HJ, Lander ES, and Lernmark Å. Thyroiditis in the BB rat is associated with lymphopenia but occurs independently of diabetes. J. Autoimmunity, 8:493-505, 1995.
  17. Kockum I, Sanjeevi CB, Eastman S, Landin-Olsson M, Dahlquist G, and Lernmark Å. Population analysis of HLA-DR and DQ gene protection from insulin-dependent diabetes mellitus in Swedish insulin-dependent diabetes children and controls. Eur. J. Immunogenetics, 22:443-465, 1995.
  18. Gold DP, Shaikewitz ST, Mueller D, Redd JR, Sellins KS, Pettersson A, Lernmark Å, and Bellgrau D. T cells from BB-DP rats show a unique cytokine mRNA profile associated with the iddm1 susceptibility gene, Lyp. Autoimmunity 22:149-161, 1995.

 
 
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