OTHER SUPPORT

 

LERNMARK, ÅKE

UNIVERSITY OF WASHINGTON

 

ACTIVE

PO1-AI42380-09 (Lernmark)                                           08/01/05-01/31/10         1.2 calendar, Project 1

NIH/NIAID                                                                          $825,912                        0.60  calendar, Core A

Genetic control of BB rat autoimmunity

 

      This Program Project aims to uncover genes which control the development of spontaneous organ-specific autoimmune disease in the rat.  Lymphopenia (lyp), insulitis and thyroiditis phenotypes are analyzed and genetic factors positionally cloned in congenic BB and Fischer rats.

 

1UO1 DK063861-04 (Lernmark)                                    01/1/03-12/30/07            2.4 calendar

NIH/NIDDK                                                                        $722,838

      TEDDY - Diabetes Prediction in Skåne (DiPiS)

 

This study is a consortium of six clinical centers in the TEDDY (Triggers and Environmental Determinants of Diabetes in the Young) study. DiPiS will screen 10,000 children per year for high risk HLA and other T1DM genetic factors.

 

DK17047-20 (Program Director: Palmer, Molecular and Genetics Core Director: Lernmark)

      NIH/NIDDK                                                                                                                                                                  12/01/02-11/30/07                                                                                                    1.2 calendar (donated)

      Diabetes Endocrinology Research Center (DERC)        $84,362                                  

                                                                                               

      The Molecular and Genetics Core is providing: (a) consultation and training, (b) preparation and dissemination of molecular biology reagents, and (c) service work to carry out specific molecular biology projects or genetic mapping.

 

      7-03-MN-30 (Lernmark)                                                  07/01/03-06/30/07            0 calendar

      American Diabetes Association                                       $45,000

      Ian5 Gene Induction of Type 1 Diabetes, Mentor Based Fellowship

 

      This grant is to support a fellow to work on identifying how this mutation defect, present from birth, initiated T-cell mediated ß-cell destruction at 50-80 days of age in the lymphopenic diabetes-prone (DP) BB rat.

     

      1-04-TLG-06 (Lernmark)                                                            01/01/04-12/31/06             0.60 calendar

      American Diabetes Association                                       $100,000

      Gregg Award

 

      The objective is to determine the impact of cord blood autoantibodies on type 1 diabetes development in children with high risk HLA.  The long term goal is to develop measures of tolerance induction that can be used to prevent type 1 diabetes.

 

      P30DK47754   (Osborne)                                               01/01/05-12/31/06             0.60 calendar

      NIH/NIAID, Pilot and Feasibility Award                              $200,000

      Lentivirus-mediated transfer of IAN5 to treat type 1 diabetic rats

 

The objective of this research is to investigate lentivirus-mediated gene therapy to treat spontaneously diabetic BB rats, a well characterized model of T1DM. We propose to use lentivirus vectors to transduce bone marrow stem cells to express wild type IAN5 cDNA under the control of a thymocyte specific promoter. These studies will provide necessary pre-clinical data of lentivirus-mediated gene therapy of diabetic rats that may lead to application to patients.  

 

PO1 DK053004 (Lernmark)                                            07/15/05-06/30/08               1.8 calendar, Project 2

NIH/NIDDK                                                                        $711,341                              0.60 calendar, Core A

Immunogenetics of Human Diabetes

 

Determine the mechanisms of type 1 diabetes development in non-progressors and progressors to disease.  Analyze the interaction between T and B lymphocytes as well as the autoimmune response in patients with type 2 diabetes as well as at children at risk for developing diabetes.

 

4-2001-433 (Gerald Nepom, Center Director; Lernmark P.I. on subcontract)                   

3/1/03-9/30/06                      0.60 calendar

Juvenile Diabetes Research Foundation                          $72,727

JDRF Center for Translational Research at the Benaroya Research Institute at Virginia Mason

 

Profiling of islet antigen specific immunity in IDDM.

 

      2 R01 DK026190-19A2 (Lernmark)                                04/01/06-02/28/11               1.8 calendar

      NIH/NIDDK                                                                        $205,000

      Islet Cell Membrane Antibodies in Diabetes

 

The long-term objective of this continued application is to identify the role of beta cell autoantigens in insulin-dependent diabetes mellitus.  Epitope mapping of GAD65 antibodies tested to predict disease.

 

PENDING

      None.

 

OVERLAP

None.