SIGMA-ALDRICH 2004.3
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MATERIAL SAFETY DATA SHEET
Date Printed: 07/09/2004
Date Updated: 09/05/2002
Version 1.4
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Section 1 - Product and Company Information
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Product Name PROPYLENE OXIDE, 99% (MINI-BULK)
Product Number 471968
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS, MO 63103
USA
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
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Section 2 - Composition/Information on Ingredient
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Substance Name CAS # SARA 313
PROPYLENE OXIDE 75-56-9 Yes
Formula C3H6O
Synonyms AD 6 (suspending agent),Epoxypropane,1,
2-Epoxypropane,1,2-Epoxypropane (ACGIH:OSHA),2,
3-Epoxypropane,Ethylene oxide, methyl-,
Methyl ethylene oxide,Methyloxacyclopropane,
Methyl oxirane,NCI-C50099,Oxirane, methyl-,
Oxyde de propylene (French),Propane, epoxy-,
Propene oxide,Propylene epoxide,Propylene oxide,1,
2-Propylene oxide,Propylene oxide (DOT:OSHA)
RTECS Number: TZ2975000
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Flammable (USA) Extremely Flammable (EU). Toxic.
May cause cancer. Causes burns. Harmful by inhalation, in contact
with skin and if swallowed.
Readily absorbed through skin. Target organ(s): Central nervous
system. Calif. Prop. 65 carcinogen.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 4
REACTIVITY: 1
NFPA RATING
HEALTH: 3
FLAMMABILITY: 4
REACTIVITY: 1
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
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Section 4 - First Aid Measures
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ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
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Section 5 - Fire Fighting Measures
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FLAMMABLE HAZARDS
Flammable Hazards: Yes
EXPLOSION HAZARDS
Vapor may travel considerable distance to source of ignition and
flash back. Container explosion may occur under fire conditions.
CONDITIONS OF FLAMMABILITY
Under fire conditions, material may decompose to form flammable
and/or explosive mixtures in air.
FLASH POINT
-34.6 F -37 C Method: closed cup
EXPLOSION LIMITS
Lower: 2.1 % Upper: 37 %
AUTOIGNITION TEMP
748 C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Flammable liquid. Vapor may travel
considerable distance to source of ignition and flash back.
Emits toxic fumes under fire conditions.
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Section 6 - Accidental Release Measures
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PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
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Section 7 - Handling and Storage
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HANDLING
User Exposure: Do not breathe vapor. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep container closed. Keep away from heat, sparks,
and open flame. Store in a cool dry place.
SPECIAL REQUIREMENTS
May develop pressure. Open carefully. Heat sensitive. Cool to
0C before opening.
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Section 8 - Exposure Controls / PPE
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ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Use only in a
chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 20 PPM
USA MSHA Standard-air TWA 100 PPM (240 MG/M3)
USA OSHA. PEL 8H TWA 100 PPM (240 MG/M3)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH LOWEST FEASIBLE CONCENTRTION
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Section 9 - Physical/Chemical Properties
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Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
Molecular Weight 58.08 AMU
pH N/A
BP/BP Range 34 - 35 C
MP/MP Range -112 C
Freezing Point N/A
Vapor Pressure 444.103 mmHg 20 C
Vapor Density 2 g/l
Saturated Vapor Conc. N/A
SG/Density 0.829 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content < 0.1 %
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point -34.6 F -37 C Method: closed cup
Explosion Limits Lower: 2.1 %
Upper: 37 %
Flammability N/A
Autoignition Temp 748 C
Refractive Index 1.366
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
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Section 10 - Stability and Reactivity
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STABILITY
Stable: Stable.
Conditions to Avoid: Protect from heat.
Materials to Avoid: Oxidizing agents Copper, Copper alloys, Strong
acids, Strong bases, Peroxides, Alkali, Amines.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: May occur Product may explode if
polymerization is initiated in closed containers
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Section 11 - Toxicological Information
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ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Harmful if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes burns.
Inhalation: Harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Central nervous system.
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Can cause CNS depression.
TOXICITY DATA
Oral
Rat
380 mg/kg
LD50
Remarks: Behavioral:Excitement. Behavioral:Ataxia. Lungs,
Thorax, or Respiration:Respiratory stimulation.
Inhalation
Rat
4,000 ppm
LC50
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Olfaction:Other changes. Sense Organs and Special Senses
(Nose, Eye, Ear, and Taste):Eye:Lacrimation. Lungs, Thorax, or
Respiration:Dyspnea.
Intraperitoneal
Rat
150 MG/KG
LD50
Oral
Mouse
440 mg/kg
LD50
Remarks: Behavioral:Excitement. Behavioral:Ataxia. Lungs,
Thorax, or Respiration:Respiratory stimulation.
Inhalation
Mouse
1,740 ppm
LC50
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Olfaction:Other changes. Lungs, Thorax, or
Respiration:Dyspnea. Gastrointestinal:Changes in structure or
function of salivary glands.
Intraperitoneal
Mouse
175 MG/KG
LD50
Skin
Rabbit
1500 UL/KG
LD50
Oral
Guinea pig
660 mg/kg
LD50
Remarks: Behavioral:Somnolence (general depressed activity).
Liver:Other changes. Kidney, Ureter, Bladder:Other changes.
Oral
Mammal
440 mg/kg
LD50
IRRITATION DATA
Skin
Rabbit
415 mg
Remarks: Open irritation test
Skin
Rabbit
50 mg
6M
Remarks: Severe irritation effect
Eyes
Rabbit
20 mg
Remarks: Severe irritation effect
Eyes
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be probably carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Species: Rat
Route of Application: Oral
Dose: 10798 MG/KG
Exposure Time: 2Y
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Gastrointestinal:Tumors.
Species: Mouse
Route of Application: Inhalation
Dose: 400 PPM
Exposure Time: 6H/2Y
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
Species: Rat
Route of Application: Inhalation
Dose: 100 PPM
Exposure Time: 7H/2Y
Frequency: I
Result: Tumorigenic:Neoplastic by RTECS criteria.
Endocrine:Tumors.
Species: Rat
Route of Application: Subcutaneous
Dose: 1500 MG/KG
Exposure Time: 46W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic:Facilitates action of known carcinogens.
Species: Mouse
Route of Application: Inhalation
Dose: 400 PPM
Exposure Time: 6H/2Y
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
Species: Mouse
Route of Application: Subcutaneous
Dose: 272 MG/KG
Exposure Time: 95W
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors
at site or application.
Species: Mouse
Route of Application: Subcutaneous
Dose: 3640 MG/KG
Exposure Time: 91W
Frequency: I
Result: Tumorigenic:Neoplastic by RTECS criteria.
Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors
at site or application.
Species: Mouse
Route of Application: Subcutaneous
Dose: 868 MG/KG
Exposure Time: 95W
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors
at site or application.
Species: Mouse
Route of Application: Subcutaneous
Dose: 2912 MG/KG
Exposure Time: 95W
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors
at site or application.
Species: Mouse
Route of Application: Subcutaneous
Dose: 6616 MG/KG
Exposure Time: 95W
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors
at site or application.
Species: Rat
Route of Application: Oral
Dose: 2714 MG/KG
Exposure Time: 2Y
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Gastrointestinal:Tumors.
Species: Rat
Route of Application: Inhalation
Dose: 400 PPM
Exposure Time: 6H/2Y
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Olfaction:Tumors.
Species: Rat
Route of Application: Inhalation
Dose: 300 PPM
Exposure Time: 6H/2.3Y
Frequency: I
Result: Tumorigenic:Neoplastic by RTECS criteria. Skin and
Appendages: Other: Tumors.
IARC CARCINOGEN LIST
Rating: Group 2B
NTP CARCINOGEN LIST
Rating: Clear evidence.
Species: Mouse
Route: Inhalation
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 500 PPM/7H
Route of Application: Inhalation
Exposure Time: (7-16D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Rat
Dose: 500 PPM/7H
Route of Application: Inhalation
Exposure Time: (1-16D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
Species: Human
Dose: 1850 UG/L
Cell Type: lymphocyte
Mutation test: Cytogenetic analysis
Species: Human
Dose: 25000 PPM
Cell Type: lymphocyte
Mutation test: Sister chromatid exchange
Species: Rat
Dose: 30 UMOL/L
Cell Type: liver
Mutation test: DNA damage
Species: Rat
Dose: 25 UG/L
Cell Type: liver
Mutation test: Cytogenetic analysis
Species: Rat
Route: Inhalation
Dose: 300 PPM
Exposure Time: 5D
Mutation test: Dominant lethal test
Species: Mouse
Route: Intraperitoneal
Dose: 600 MG/KG
Exposure Time: 24H
Mutation test: Micronucleus test
Species: Mouse
Dose: 160 PPM
Exposure Time: 48H
Cell Type: lymphocyte
Mutation test: specific locus test
Species: Mouse
Route: Intraperitoneal
Dose: 200 MG/KG
Mutation test: DNA damage
Species: Mouse
Route: Intraperitoneal
Dose: 349 MG/KG
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Intraperitoneal
Dose: 232 MG/KG
Mutation test: Sister chromatid exchange
Species: Mouse
Dose: 400 UG/L
Cell Type: lymphocyte
Mutation test: Mutation in mammalian somatic cells.
Species: Hamster
Dose: 160 MG/L
Cell Type: ovary
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 5 MG/L
Cell Type: ovary
Mutation test: Sister chromatid exchange
Species: Hamster
Dose: 2500 UMOL/L
Cell Type: lung
Mutation test: Sister chromatid exchange
Species: Mammal
Dose: 75 MMOL/L
Cell Type: lymphocyte
Mutation test: DNA damage
Species: Mammal
Dose: 100 MMOL/TUBE
Cell Type: lymphocyte
Mutation test: DNA
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 500 PPM/7H
Route of Application: Inhalation
Exposure Time: (15D PRE/1-16D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility: Litter size
(e.g.; # fetuses per litter; measured before birth). Effects on
Fertility: Other measures of fertility
Species: Rat
Dose: 47 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Rat
Dose: 1860 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (6W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct.
Species: Monkey
Dose: 100 PPM/7H
Route of Application: Inhalation
Exposure Time: (2Y MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
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Section 12 - Ecological Information
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No data available.
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Section 13 - Disposal Considerations
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APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
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Section 14 - Transport Information
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DOT
Proper Shipping Name: Propylene oxide
UN#: 1280
Class: 3
Packing Group: Packing Group I
Hazard Label: Flammable liquid
PIH: Not PIH
IATA
Proper Shipping Name: Propylene oxide
IATA UN Number: 1280
Hazard Class: 3
Packing Group: I
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Section 15 - Regulatory Information
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EU DIRECTIVES CLASSIFICATION
Symbol of Danger: F+ T
Indication of Danger: Extremely Flammable. Toxic.
R: 45 46 12 20/21/22 36/37/38
Risk Statements: May cause cancer. May cause heritable genetic
damage. Extremely flammable. Harmful by inhalation, in contact
with skin and if swallowed. Irritating to eyes, respiratory
system and skin.
S: 53 45
Safety Statements: Restricted to professional users. Attention -
Avoid exposure - obtain special instructions before use. In case
of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Flammable (USA) Extremely Flammable (EU).
Toxic.
Risk Statements: May cause cancer. Causes burns. Harmful by
inhalation, in contact with skin and if swallowed.
Safety Statements: Restricted to professional users. Attention -
Avoid exposure - obtain special instructions before use. Keep
away from sources of ignition - no smoking. Take precautionary
measures against static discharges. In case of contact with
eyes, rinse immediately with plenty of water and seek medical
advice. Wear suitable protective clothing, gloves, and eye/face
protection. In case of accident or if you feel unwell, seek
medical advice immediately (show the label where possible).
US Statements: Readily absorbed through skin. Target organ(s):
Central nervous system. Calif. Prop. 65 carcinogen.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 0.1 %
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: This product is or contains chemical(s)
known to the state of California to cause cancer.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
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Section 16 - Other Information
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DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide.
Sigma-Aldrich Inc., shall not be held liable for any damage
resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms
and conditions of sale. Copyright 2003 Sigma-Aldrich Co. License
granted to make unlimited paper copies for internal use only.
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