SIGMA-ALDRICH 2004.3 ----------------------------------------------------------------------- MATERIAL SAFETY DATA SHEET Date Printed: 07/09/2004 Date Updated: 09/05/2002 Version 1.4 ----------------------------------------------------------------------- Section 1 - Product and Company Information ----------------------------------------------------------------------- Product Name PROPYLENE OXIDE, 99% (MINI-BULK) Product Number 471968 Brand ALDRICH Company Sigma-Aldrich Street Address 3050 Spruce Street City, State, Zip, Country SAINT LOUIS, MO 63103 USA Technical Phone: 314 771 5765 Emergency Phone: 414 273 3850 Ext. 5996 Fax: 800 325 5052 ----------------------------------------------------------------------- Section 2 - Composition/Information on Ingredient ----------------------------------------------------------------------- Substance Name CAS # SARA 313 PROPYLENE OXIDE 75-56-9 Yes Formula C3H6O Synonyms AD 6 (suspending agent),Epoxypropane,1, 2-Epoxypropane,1,2-Epoxypropane (ACGIH:OSHA),2, 3-Epoxypropane,Ethylene oxide, methyl-, Methyl ethylene oxide,Methyloxacyclopropane, Methyl oxirane,NCI-C50099,Oxirane, methyl-, Oxyde de propylene (French),Propane, epoxy-, Propene oxide,Propylene epoxide,Propylene oxide,1, 2-Propylene oxide,Propylene oxide (DOT:OSHA) RTECS Number: TZ2975000 ----------------------------------------------------------------------- Section 3 - Hazards Identification ----------------------------------------------------------------------- EMERGENCY OVERVIEW Flammable (USA) Extremely Flammable (EU). Toxic. May cause cancer. Causes burns. Harmful by inhalation, in contact with skin and if swallowed. Readily absorbed through skin. Target organ(s): Central nervous system. Calif. Prop. 65 carcinogen. HMIS RATING HEALTH: 3* FLAMMABILITY: 4 REACTIVITY: 1 NFPA RATING HEALTH: 3 FLAMMABILITY: 4 REACTIVITY: 1 *additional chronic hazards present. For additional information on toxicity, please refer to Section 11. ----------------------------------------------------------------------- Section 4 - First Aid Measures ----------------------------------------------------------------------- ORAL EXPOSURE If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately. INHALATION EXPOSURE If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. DERMAL EXPOSURE In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician. EYE EXPOSURE In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician. ----------------------------------------------------------------------- Section 5 - Fire Fighting Measures ----------------------------------------------------------------------- FLAMMABLE HAZARDS Flammable Hazards: Yes EXPLOSION HAZARDS Vapor may travel considerable distance to source of ignition and flash back. Container explosion may occur under fire conditions. CONDITIONS OF FLAMMABILITY Under fire conditions, material may decompose to form flammable and/or explosive mixtures in air. FLASH POINT -34.6 F -37 C Method: closed cup EXPLOSION LIMITS Lower: 2.1 % Upper: 37 % AUTOIGNITION TEMP 748 C FLAMMABILITY N/A EXTINGUISHING MEDIA Suitable: Carbon dioxide, dry chemical powder, or appropriate foam. Unsuitable: Water may be effective for cooling, but may not effect extinguishment. FIREFIGHTING Protective Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Specific Hazard(s): Flammable liquid. Vapor may travel considerable distance to source of ignition and flash back. Emits toxic fumes under fire conditions. ----------------------------------------------------------------------- Section 6 - Accidental Release Measures ----------------------------------------------------------------------- PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL Evacuate area. Shut off all sources of ignition. PROCEDURE(S) OF PERSONAL PRECAUTION(S) Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves. METHODS FOR CLEANING UP Cover with dry-lime, sand, or soda ash. Place in covered containers using non-sparking tools and transport outdoors. Ventilate area and wash spill site after material pickup is complete. ----------------------------------------------------------------------- Section 7 - Handling and Storage ----------------------------------------------------------------------- HANDLING User Exposure: Do not breathe vapor. Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure. STORAGE Suitable: Keep container closed. Keep away from heat, sparks, and open flame. Store in a cool dry place. SPECIAL REQUIREMENTS May develop pressure. Open carefully. Heat sensitive. Cool to 0C before opening. ----------------------------------------------------------------------- Section 8 - Exposure Controls / PPE ----------------------------------------------------------------------- ENGINEERING CONTROLS Safety shower and eye bath. Use nonsparking tools. Use only in a chemical fume hood. PERSONAL PROTECTIVE EQUIPMENT Respiratory: Government approved respirator. Hand: Compatible chemical-resistant gloves. Eye: Chemical safety goggles. GENERAL HYGIENE MEASURES Wash contaminated clothing before reuse. Wash thoroughly after handling. EXPOSURE LIMITS, RTECS Country Source Type Value USA ACGIH TWA 20 PPM USA MSHA Standard-air TWA 100 PPM (240 MG/M3) USA OSHA. PEL 8H TWA 100 PPM (240 MG/M3) New Zealand OEL Remarks: check ACGIH TLV USA NIOSH LOWEST FEASIBLE CONCENTRTION ----------------------------------------------------------------------- Section 9 - Physical/Chemical Properties ----------------------------------------------------------------------- Appearance Physical State: Clear liquid Color: Colorless Property Value At Temperature or Pressure Molecular Weight 58.08 AMU pH N/A BP/BP Range 34 - 35 C MP/MP Range -112 C Freezing Point N/A Vapor Pressure 444.103 mmHg 20 C Vapor Density 2 g/l Saturated Vapor Conc. N/A SG/Density 0.829 g/cm3 Bulk Density N/A Odor Threshold N/A Volatile% N/A VOC Content N/A Water Content < 0.1 % Solvent Content N/A Evaporation Rate N/A Viscosity N/A Surface Tension N/A Partition Coefficient N/A Decomposition Temp. N/A Flash Point -34.6 F -37 C Method: closed cup Explosion Limits Lower: 2.1 % Upper: 37 % Flammability N/A Autoignition Temp 748 C Refractive Index 1.366 Optical Rotation N/A Miscellaneous Data N/A Solubility N/A N/A = not available ----------------------------------------------------------------------- Section 10 - Stability and Reactivity ----------------------------------------------------------------------- STABILITY Stable: Stable. Conditions to Avoid: Protect from heat. Materials to Avoid: Oxidizing agents Copper, Copper alloys, Strong acids, Strong bases, Peroxides, Alkali, Amines. HAZARDOUS DECOMPOSITION PRODUCTS Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide. HAZARDOUS POLYMERIZATION Hazardous Polymerization: May occur Product may explode if polymerization is initiated in closed containers ----------------------------------------------------------------------- Section 11 - Toxicological Information ----------------------------------------------------------------------- ROUTE OF EXPOSURE Skin Contact: Causes burns. Skin Absorption: Harmful if absorbed through skin. Readily absorbed through skin. Eye Contact: Causes burns. Inhalation: Harmful if inhaled. Material is extremely destructive to the tissue of the mucous membranes and upper respiratory tract. Ingestion: Harmful if swallowed. TARGET ORGAN(S) OR SYSTEM(S) Central nervous system. SIGNS AND SYMPTOMS OF EXPOSURE Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin. Inhalation may result in spasm, inflammation and edema of the larynxand bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. Can cause CNS depression. TOXICITY DATA Oral Rat 380 mg/kg LD50 Remarks: Behavioral:Excitement. Behavioral:Ataxia. Lungs, Thorax, or Respiration:Respiratory stimulation. Inhalation Rat 4,000 ppm LC50 Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Other changes. Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Eye:Lacrimation. Lungs, Thorax, or Respiration:Dyspnea. Intraperitoneal Rat 150 MG/KG LD50 Oral Mouse 440 mg/kg LD50 Remarks: Behavioral:Excitement. Behavioral:Ataxia. Lungs, Thorax, or Respiration:Respiratory stimulation. Inhalation Mouse 1,740 ppm LC50 Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Other changes. Lungs, Thorax, or Respiration:Dyspnea. Gastrointestinal:Changes in structure or function of salivary glands. Intraperitoneal Mouse 175 MG/KG LD50 Skin Rabbit 1500 UL/KG LD50 Oral Guinea pig 660 mg/kg LD50 Remarks: Behavioral:Somnolence (general depressed activity). Liver:Other changes. Kidney, Ureter, Bladder:Other changes. Oral Mammal 440 mg/kg LD50 IRRITATION DATA Skin Rabbit 415 mg Remarks: Open irritation test Skin Rabbit 50 mg 6M Remarks: Severe irritation effect Eyes Rabbit 20 mg Remarks: Severe irritation effect Eyes Rabbit 20 mg 24H Remarks: Moderate irritation effect CHRONIC EXPOSURE - CARCINOGEN Result: This product is or contains a component that has been reported to be probably carcinogenic based on its IARC, OSHA, ACGIH, NTP, or EPA classification. Species: Rat Route of Application: Oral Dose: 10798 MG/KG Exposure Time: 2Y Frequency: I Result: Tumorigenic:Carcinogenic by RTECS criteria. Gastrointestinal:Tumors. Species: Mouse Route of Application: Inhalation Dose: 400 PPM Exposure Time: 6H/2Y Frequency: I Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors. Species: Rat Route of Application: Inhalation Dose: 100 PPM Exposure Time: 7H/2Y Frequency: I Result: Tumorigenic:Neoplastic by RTECS criteria. Endocrine:Tumors. Species: Rat Route of Application: Subcutaneous Dose: 1500 MG/KG Exposure Time: 46W Frequency: I Result: Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Tumorigenic:Facilitates action of known carcinogens. Species: Mouse Route of Application: Inhalation Dose: 400 PPM Exposure Time: 6H/2Y Frequency: I Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors. Species: Mouse Route of Application: Subcutaneous Dose: 272 MG/KG Exposure Time: 95W Frequency: I Result: Tumorigenic:Carcinogenic by RTECS criteria. Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors at site or application. Species: Mouse Route of Application: Subcutaneous Dose: 3640 MG/KG Exposure Time: 91W Frequency: I Result: Tumorigenic:Neoplastic by RTECS criteria. Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors at site or application. Species: Mouse Route of Application: Subcutaneous Dose: 868 MG/KG Exposure Time: 95W Frequency: I Result: Tumorigenic:Carcinogenic by RTECS criteria. Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors at site or application. Species: Mouse Route of Application: Subcutaneous Dose: 2912 MG/KG Exposure Time: 95W Frequency: I Result: Tumorigenic:Carcinogenic by RTECS criteria. Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors at site or application. Species: Mouse Route of Application: Subcutaneous Dose: 6616 MG/KG Exposure Time: 95W Frequency: I Result: Tumorigenic:Carcinogenic by RTECS criteria. Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors at site or application. Species: Rat Route of Application: Oral Dose: 2714 MG/KG Exposure Time: 2Y Frequency: I Result: Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Gastrointestinal:Tumors. Species: Rat Route of Application: Inhalation Dose: 400 PPM Exposure Time: 6H/2Y Frequency: I Result: Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors. Species: Rat Route of Application: Inhalation Dose: 300 PPM Exposure Time: 6H/2.3Y Frequency: I Result: Tumorigenic:Neoplastic by RTECS criteria. Skin and Appendages: Other: Tumors. IARC CARCINOGEN LIST Rating: Group 2B NTP CARCINOGEN LIST Rating: Clear evidence. Species: Mouse Route: Inhalation CHRONIC EXPOSURE - TERATOGEN Species: Rat Dose: 500 PPM/7H Route of Application: Inhalation Exposure Time: (7-16D PREG) Result: Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Specific Developmental Abnormalities: Musculoskeletal system. Species: Rat Dose: 500 PPM/7H Route of Application: Inhalation Exposure Time: (1-16D PREG) Result: Specific Developmental Abnormalities: Craniofacial (including nose and tongue). CHRONIC EXPOSURE - MUTAGEN Result: Laboratory experiments have shown mutagenic effects. Species: Human Dose: 1850 UG/L Cell Type: lymphocyte Mutation test: Cytogenetic analysis Species: Human Dose: 25000 PPM Cell Type: lymphocyte Mutation test: Sister chromatid exchange Species: Rat Dose: 30 UMOL/L Cell Type: liver Mutation test: DNA damage Species: Rat Dose: 25 UG/L Cell Type: liver Mutation test: Cytogenetic analysis Species: Rat Route: Inhalation Dose: 300 PPM Exposure Time: 5D Mutation test: Dominant lethal test Species: Mouse Route: Intraperitoneal Dose: 600 MG/KG Exposure Time: 24H Mutation test: Micronucleus test Species: Mouse Dose: 160 PPM Exposure Time: 48H Cell Type: lymphocyte Mutation test: specific locus test Species: Mouse Route: Intraperitoneal Dose: 200 MG/KG Mutation test: DNA damage Species: Mouse Route: Intraperitoneal Dose: 349 MG/KG Mutation test: Cytogenetic analysis Species: Mouse Route: Intraperitoneal Dose: 232 MG/KG Mutation test: Sister chromatid exchange Species: Mouse Dose: 400 UG/L Cell Type: lymphocyte Mutation test: Mutation in mammalian somatic cells. Species: Hamster Dose: 160 MG/L Cell Type: ovary Mutation test: Cytogenetic analysis Species: Hamster Dose: 5 MG/L Cell Type: ovary Mutation test: Sister chromatid exchange Species: Hamster Dose: 2500 UMOL/L Cell Type: lung Mutation test: Sister chromatid exchange Species: Mammal Dose: 75 MMOL/L Cell Type: lymphocyte Mutation test: DNA damage Species: Mammal Dose: 100 MMOL/TUBE Cell Type: lymphocyte Mutation test: DNA CHRONIC EXPOSURE - REPRODUCTIVE HAZARD Species: Rat Dose: 500 PPM/7H Route of Application: Inhalation Exposure Time: (15D PRE/1-16D PREG) Result: Effects on Fertility: Pre-implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea). Effects on Fertility: Litter size (e.g.; # fetuses per litter; measured before birth). Effects on Fertility: Other measures of fertility Species: Rat Dose: 47 MG/KG Route of Application: Intraperitoneal Exposure Time: (1D MALE) Result: Paternal Effects: Spermatogenesis (including genetic material, sperm morphology,motility, and count). Species: Rat Dose: 1860 MG/KG Route of Application: Intraperitoneal Exposure Time: (6W MALE) Result: Paternal Effects: Spermatogenesis (including genetic material, sperm morphology,motility, and count). Paternal Effects: Testes, epididymis, sperm duct. Species: Monkey Dose: 100 PPM/7H Route of Application: Inhalation Exposure Time: (2Y MALE) Result: Paternal Effects: Spermatogenesis (including genetic material, sperm morphology,motility, and count). ----------------------------------------------------------------------- Section 12 - Ecological Information ----------------------------------------------------------------------- No data available. ----------------------------------------------------------------------- Section 13 - Disposal Considerations ----------------------------------------------------------------------- APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION Contact a licensed professional waste disposal service to dispose of this material. Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Observe all federal, state, and local environmental regulations. ----------------------------------------------------------------------- Section 14 - Transport Information ----------------------------------------------------------------------- DOT Proper Shipping Name: Propylene oxide UN#: 1280 Class: 3 Packing Group: Packing Group I Hazard Label: Flammable liquid PIH: Not PIH IATA Proper Shipping Name: Propylene oxide IATA UN Number: 1280 Hazard Class: 3 Packing Group: I ----------------------------------------------------------------------- Section 15 - Regulatory Information ----------------------------------------------------------------------- EU DIRECTIVES CLASSIFICATION Symbol of Danger: F+ T Indication of Danger: Extremely Flammable. Toxic. R: 45 46 12 20/21/22 36/37/38 Risk Statements: May cause cancer. May cause heritable genetic damage. Extremely flammable. Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. S: 53 45 Safety Statements: Restricted to professional users. Attention - Avoid exposure - obtain special instructions before use. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). US CLASSIFICATION AND LABEL TEXT Indication of Danger: Flammable (USA) Extremely Flammable (EU). Toxic. Risk Statements: May cause cancer. Causes burns. Harmful by inhalation, in contact with skin and if swallowed. Safety Statements: Restricted to professional users. Attention - Avoid exposure - obtain special instructions before use. Keep away from sources of ignition - no smoking. Take precautionary measures against static discharges. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves, and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). US Statements: Readily absorbed through skin. Target organ(s): Central nervous system. Calif. Prop. 65 carcinogen. UNITED STATES REGULATORY INFORMATION SARA LISTED: Yes DEMINIMIS: 0.1 % NOTES: This product is subject to SARA section 313 reporting requirements. TSCA INVENTORY ITEM: Yes UNITED STATES - STATE REGULATORY INFORMATION CALIFORNIA PROP - 65 California Prop - 65: This product is or contains chemical(s) known to the state of California to cause cancer. CANADA REGULATORY INFORMATION WHMIS Classification: This product has been classified in accordance with the hazard criteria of the CPR, and the MSDS contains all the information required by the CPR. DSL: Yes NDSL: No ----------------------------------------------------------------------- Section 16 - Other Information ----------------------------------------------------------------------- DISCLAIMER For R&D use only. Not for drug, household or other uses. WARRANTY The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. Sigma-Aldrich Inc., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. Copyright 2003 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only. |