SAAM II, Version 1.2 Features

Compartmental Application

Fast Setup for model and experiment building (point and click):
- No programming or pseudo code,
- Easy construction of complex models and complex experimental protocols,
- Generates systems of equations automatically from the model structure; users can define additional equations.
Flexible input capability includes bolus, constant infusion, primed infusion and equation.
Forcing functions are easily inserted as user-defined or associated with data.
Change conditions can be easily defined.
User can choose any of 3 differential equation integrators

Users can define numerical models directly with a set of algebraic equations; the Numerical application includes comprehensive sets of functions and mathematical operators
Equation Builder provides a choice of equation sets including Michaelis-Menten, Scatchard, Sum of Gaussians, Sum of Polynomials, and Sum of Exponentials; Sum of Exponentials provides choices for exogenous inputs.

Data may be entered directly in the Data window or loaded from other applications; SAAM II formatting can be added after data is loaded.
Model parameters are automatically determined from equation variables; parameters may be defined as fixed, adjustable or Bayesian; user can easily edit values and types.

Flexible, efficient and accurate Optimizer for computational optimization:
- Choose Data or Model variance as the Variance Model.
- Choose Absolute or Relative for data weighting.
- Choose Forward Derivative (faster) or Central Derivative (smaller total error).
- Set convergence criteria to control optimization speed versus accuracy.
- Allows use of a Bayesian term to incorporate prior knowledge of an adjustable parameter.
User’s Notes can be included in Study Files to document particular items of interest in a model and/or experiment: setup, conclusions, etc.
Includes Users Guide with examples and detailed on-line Help.
Progress Display during analysis.
Compartmental and Numerical Models are solved and fitted to data automatically.

Study results may be plotted or listed in tables;
Results may be exported to other applications.
QuickPlot displays plots for individual Compartmental objects or single defined Numerical variables.
Complete results may be automatically saved to a text file.
Statistics for Correlation Matrix, Covariance Matrix and Objective Function are calculated.
Confidence Intervals on study parameters provide upper and lower bounds on each parameter.