Zhang Z, Hesselberth JR, Fields S. Genome-wide identification of spliced introns using a tiling microarray.
Genome Res. 2007 Mar 9. download pdf, supplemental data

Kaeberlein TL, Smith ED, Tsuchiya M, Welton KL, Thomas JH, Fields S, Kennedy BK, Kaeberlein M. Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell. 2006 Dec;5(6):487-94. download pdf

Montpetit B, Hazbun TR, Fields S, Hieter P. Sumoylation of the budding yeast kinetochore protein Ndc10 is required for Ndc10 spindle localization and regulation of anaphase spindle elongation. J Cell Biol. 2006 Aug 28;174(5):653-63. download pdf

Kaeberlein M, Steffen KK, Hu D, Dang N, Kerr EO, Tsuchiya M, Fields S, Kennedy BK. Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction". Science. 2006 Jun 2;312(5778):1312. download pdf

Hesselberth JR, Miller JP, Golob A, Stajich JE, Michaud GA, Fields S. Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins. Genome Biol. 2006 Apr 10;7(4):R30. download pdf

Jin F, Hazbun T, Michaud GA, Salcius M, Predki PF, Fields S, Huang J. A pooling-deconvolution strategy for biological network elucidation. Nature Methods. 2006 Mar;3(3):183-9. download pdf

Brown V, Brown RA, Ozinsky A, Hesselberth JR, Fields S. Binding specificity of Toll-like receptor cytoplasmic domains. Eur J Immunol. 2006 Mar;36(3):742-53. download pdf

Powers RW 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 2006 Jan 15;20(2):174-84. download pdf

Kaeberlein M, Hu D, Kerr EO, Tsuchiya M, Westman EA, Dang N, Fields S, Kennedy BK. Increased Life Span due to Calorie Restriction in Respiratory-Deficient Yeast. PLoS Genet. 2005 Nov 25;1(5):e69. download pdf

Kaeberlein M, Powers RW 3rd, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science. 2005 Nov 18;310(5751):1193-6. download pdf

Lacount DJ, Vignali M, Chettier R, Phansalkar A, Bell R, Hesselberth JR, Schoenfeld LW, Ota I, Sahasrabudhe S, Kurschner C, Fields S, Hughes RE. A protein interaction network of the malaria parasite Plasmodium falciparum. Nature. 2005 Nov 3;438(7064):103-7. download pdf

Fields S. (2005) High-throughput two-hybrid analysis. The promise and the peril. FEBS J. Nov;272(21):5391-9. download pdf

Miller J.P., Lo R.S., Ben-Hur A, Desmarais C, Stagljar I, Stafford Noble W, Fields S.(2005) Large-scale identification of yeast integral membrane protein interactions. Proc Natl Acad Sci USA. Aug 23;102(34):12123-12128. supplemental data, download pdf

Natter K, Leitner P, Faschinger A, Wolinski H, McCraith S, Fields S, Kohlwein SD. (2005) The Spatial Organization of Lipid Synthesis in the Yeast Saccharomyces cerevisiae Derived from Large Scale Green Fluorescent Protein Tagging and High Resolution Microscopy. Mol Cell Proteomics. May;4(5):662-672. download pdf

Devit M, Cullen PJ, Branson M, Sprague GF Jr, Fields S. (2005) Forcing interactions as a genetic screen to identify proteins that exert a defined activity. Genome Res. Apr;15(4):560-5. download pdf

Fields S, Johnston M. (2005) Cell biology. Whither model organism research? Science. Mar 25;307(5717):1885-6. download pdf

Kaeberlein M, Kirkland KT, Fields S, Kennedy BK. (2005) Genes determining yeast replicative life span in a long-lived genetic background. Mech Ageing Dev. Apr;126(4):491-504. download pdf

Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell S, Napper A, Curtis R, Distefano PS, Fields S, Bedalov A, Kennedy BK. (2005) Substrate specific activation fo sirtuins by resveratrol.
J Biol Chem. Apr 29;280(17):17038-45. download pdf

Jeffress M, Fields S. (2005) Identification of putative Plasmodium falciparum mefloquine resistance genes. Mol Biochem Parasitol. Feb;139(2):133-9. download pdf

Antoniacci LM, Kenna MA, Uetz P, Fields S, Skibbens RV. (2004) The spindle pole body assembly component mps3p/nep98p functions in sister chromatid cohesion. J Biol Chem. Nov 19;279(47):49542-50. download pdf

Kaeberlein, M., Kirkland, K.T., Fields, S. and Kennedy, B.K. (2004) Sir2-independent life span extension by calorie restriction in yeast. PLoS Biology Sep;2(9):E296. download pdf

Alexandrov, A., Vignali, M., LaCount, D.J., Quartley, E., de Vries, C., DeRosa, D., Babulski, J., Mitchell, S., Schoenfeld, L.W., Fields, S., Hol, W.G., Dumont, M.E., Phizicky, E.M. and Grayhack,E.J. (2004) A facile method for high-throughput co-expression of protein pairs. Molecular and Cellular proteomics Sep;3(9):934-938. download pdf

Guo, D., Hazbun, T.R., Xu, X.-J., Ng, S.-L., Fields, S. and Kuo, M.-H. (2004) A tethered catalysis two-hybrid system to identify protein-protein interactions requiring post-translational modifications. Nature Biotechnology Jul;22(7):888-892. download pdf

Tucker, C.L. and Fields, S. (2004) Quantitative genome-wide analysis of yeast deletion strain sensitivities to oxidative and chemical stress. Comparative and Functional Genomics 5:216-224. supplemental data, download pdf

Hazbun, T.R., Malmström, L., Anderson, S., Graczyk, B.J., Fox, B., Riffle, M., Sundin, B.A., Aranda, J.D., McDonald, W.H., Chun, C., Snydsman, B.E., Bradley, P., Muller, E.G.D., Fields, S., Baker, D., Yates, J.R. III and Davis, T.N. (2003) Assigning function to yeast proteins by integration of technologies. Molecular Cell Dec;12(6):1353-1365. download pdf

Tucker CL, Fields S. (2003) Lethal combinations. Nat Genet. 2003 Nov;35(3):204-5. download pdf

Guo, M., Uetz, P., Burchett, S.A., Fields, S. and Dohlman, H.G. (2003) The yeast G protein alpha subunit Gpa1 transmits a signal through a novel effector RNA-binding protein Scp160. Mol. Cell, Aug;12(2):517-524. download pdf

Shang, C., Hazbun, T.R., Cheeseman, I.M., Aranda, J., Fields, S., Drubin, D.G. and Barnes, G. (2003) Kinetochore protein interactions and their regulation by the Aurora kinase Ipl1p. Molecular Biology of the Cell Aug;14(8):3342-55. download pdf

Kitagawa, K., Abdulle, R., Bansal, P.K., Cagney, G., Fields, S. and Hieter, P. (2003) Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint. Molecular Cell May;11(5):1201-1213. download pdf

Phizicky, E., Bastiaens, P. I. H., Zhu, H., Snyder, M. and Fields, S. (2003) Protein analysis on a proteomic scale. Nature Mar;422(6928):208-215. download pdf

Pot, I., Measday, V., Snydsman, B., Cagney, G., Fields, S., Muller, E., Davis, T.N. and Hieter, P. (2002) Chl4p and Iml3p are two new members of the budding yeast outer kinetochore. Mol. Biol. Cell Feb;14(2):460-76. download pdf

Stagljar, I. and Fields, S. (2002) Analysis of membrane protein interactions using yeast-based technologies. Trends in Biochemical Sciences Nov;27(11): 559-563. download pdf

Fields, S. (2002) Forward to Discovering Genomics, Proteomics and Bioinformatics, A.M. Campbell and L.J. Heyer (San Francisco: Benjamin Cummings), p. ix.

Hazbun, T. R. and Fields, S. (2002) A genome-wide screen for site-specific DNA binding proteins. Mol. Cell Proteomics Jul;1(7):538-43. download pdf

Phizicky, E.M., Martzen, M.R., McCraith, S. M., Spinelli, S.L., Xing, F., Shull, N.P., Van Slyke, C., Montagne, R.K., Torres, F.M., Fields, S. and Grayhack, E.J. (2002) Biochemical genomics approach to map activities to genes. Methods Enzymol 350:546-59.

von Mering, C., Krause, R., Snel, B., Cornell, M., Oliver, S.G., Fields, S. and Bork, P. (2002) Comparative assessment of large-scale data sets of protein-protein interactions. Nature May 23;417(6887):399-403. download pdf

Fields, S. and Johnston, M. (2002) Genomics. A crisis in postgenomic nomenclature. Science Apr 26;296(5568): 671-672. download pdf

Burchett, S.A., Flanary, P., Aston, C.W., Jiang, L., Young, K.H., Uetz, P., Fields, S. and Dohlman, H.G. (2002) Regulation of stress response signaling by the N-terminal DEP (dishevelled/EGL-10/pleckstrin) domain of Sst2, a regulator of G protein signaling in Saccharomyces cerevisiae. J. Biol. Chem. Jun 21;277(25):22156-67. download pdf

Measday, V., Hailey D., Pot, I., Givan, S., Hyland, K., Cagney, G., Fields, S., Davis, T. and Hieter, P. (2002) Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore . Genes and Development Jan 1;16(1):101-113. download pdf

Muchowski, P., Ning, K., D’Souza-Schorey and Fields, S. (2002) Requirement of an intact microtubule cytoskeleton for the aggregation of an amino-terminal fragment of huntingtin. Proc Natl Acad Sci USA. Jan 22;99(2): 727-732. download pdf

Gera, J.F., Hazbun, T.R. and Fields, S. (2002) Array-based methods for identifying protein-protein and protein-nucleic acid interactions. Methods Enzymol. 350:499-512.

Tong, A. H., Drees, B., Nardelli, G., Bader, G. D., Brannetti, B., Castagnoli, L., Evangelista, M., Ferracuti, S., Nelson, B., Paoluzi, S., Quondam, M., Zucconi, A., Hogue, C. W., Fields, S., Boone, C., and Cesareni, G. (2001) A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules. Science Jan 11;295(5553):284-7. download pdf

Hughes, R. E., Lo, R. S., Davis, C., Strand, A. D., Neal, C. L., Olson, J. M. and Fields, S. (2001) Altered transcription in yeast expressing polyglutamine. Proc. Natl. Acad. Sci. USA. Nov 6;98(23):13201-06. download pdf

Cagney, G., Uetz, P. and Fields, S. (2001) Two-hybrid analysis of the Saccharomyces cerevisiae 26S proteasome. Physiol. Genomics Oct 10;7(1):27-34. download pdf

Tucker, C. and Fields, S. (2001) A yeast sensor of ligand binding. Nat. Biotech. Nov;19(11):1042-1046. download pdf

Fields, S. (2001) The interplay of biology and technology. Proc. Natl. Acad. Sci. U.S.A. Aug 28;98(18):10051-10054. download pdf

Drees,B.L., Sundin, B., Brazeau, E., Caviston, J.P., Chen, G.-C., Guo, W., Kozminski, K.G., Lau, M.W., Moskow, J.J., Tong, A., Schenkman, L.R., McKenzie, A. III, Brennwald, P., Longtine, M., Bi, E., Chan, C., Novick, P., Boone, C., Pringle, J.R., Davis, T.N., Fields, S. and Drubin, D.G. (2001) A protein interaction map for cell polarity development. J. Cell Biol. Aug 6;154(3):549-571. download pdf

Fields, S. (2001) Proteomics in genomeland. Science Feb 16;291(5507):1221-1224. download pdf

Wood, J., Frederickson, R.M., Fields, S. and Patel, A.H. (2001) Hepatitis C virus 3' X region interacts with human ribosomal proteins. J. Virol. Feb;75(3):1348-1358. download pdf

Johnston, M. and Fields, S., eds. (2001) Proteomics and genomics. Presidential preference, protein purpose. Curr. Opin. Chem. Biol., 5(1):13-14.

Fields, S. (2001) Two hybrid proteins to many hybrid proteins. ASM News 67:135-143.

Hazbun, T.R. and Fields, S. (2001) Networking proteins in yeast. Proc. Natl. Acad. Sci. U.S.A. Apr 10;98(8):4277-4278. download pdf

Kraemer, B., Zhang, B., SenGupta, S., Fields, S. and Wickens, M. (2000) Using the yeast three-hybrid system to detect and analyze RNA-protein interactions. Meth. Enzym. 328:297-321.

Cagney, G., Uetz, P. and Fields, S. (2000) High-throughput screening for protein-protein interactions using two-hybrid assay. Meth. Enzym. 328:3-14.

Zhang B, Kraemer B, SenGupta D, Fields S, and Wickens M. (2000) Yeast three-hybrid system to detect and analyze RNA-protein interactions. Meth. Enzym. 318:399-419.

McCraith, S., Holtzman, T., Moss, B. and Fields, S. (2000) Genomewide analysis of vaccinia virus protein-protein interactions. Proc. Natl. Acad. Sci. U.S.A Apr 25;97(9): 4879-4884. download pdf

Crosby , J.A., Konopka, J.B. and Fields, S. (2000) Constitutive activation of the Saccharomyces cerevisiae transcriptional regulator Ste12p by mutations at the amino-terminus. Yeast Nov;16(15):1365-1375. download pdf

Schwikowski, B., Uetz, P. and Fields, S. (2000) A network of protein-protein interactions in yeast. Nature Biotech. Dec;18(12):1257-1261. download pdf

Uetz, P. Giot, L. Cagney, G. Mansfield, T. A., Judson, R. S., Narayan, V. Lockshon, D., Srinivasan, M., Pochart, P., Qureshi-Emili, A., Li, Y., Godwin, B., Conover, D., Kalbfleisch, T., Vijayadamodar, G., Yang, M., Johnston, M., Fields, S. and Rothberg, J. M. (2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature Feb 10;403(6770):623-7. download pdf

Johnson, M. and Fields, S. (2000) Grass roots genomics.  Nature Genet. Jan;24(1):5-6.

Drees, B. L. (1999) Progress and variations in two-hybrid and three-hybrid technologies. Curr. Opin. Chem. Biol. Feb;3(1):64-70. download pdf

Martzen, M. R., McCraith, S. M., Spinelli, S. L., Torres, F. M., Fields, S., Grayhack, E. J. and Phizicky, E. M. (1999) A biochemical genomics approach for identifying genes by the activity of their products. Science Nov 5;286(5442):1153-55. download pdf

Norman, T. C., Smith, D. L., Sorger, P. K., Drees, B. L., O'Rourke, S. M., Hughes, T. R., Roberts, C. J., Friend, S. H., Fields, S. and Murray, A. W. (1999) Genetic selection of peptide inhibitors of biological pathways. Science Jul 23;285(5427):591-5. download pdf

Fields, S., Kohara, Y. and Lockhart, D. J. (1999) Functional genomics. (Frontiers of Science Symposium review) Proc. Natl. Acad. Sci. Aug 3;96(16):8825-26. download pdf

Fields, S. (1999) Two-hybrid and related systems.  In Encyclopedia of Life Sciences.  London: Macmillan.

Zhang, B., Kraemer, B., SenGupta, S., Fields, S. and Wickens, M. (1999) Yeast three-hybrid system to detect and analyze interactions between RNA and protein. Meth.Enzym. 306:93-113.

Wright, M. E., Han, D. K., Carter, L., Fields, S., Schwartz, S. M., and Hockenbery, D. M. (1999) Caspase-3 inhibits growth in Saccharomyces cerevisiae without causing cell death. FEBS Lett. Mar 5;446(1):9-14. download pdf

Hughes, R. E. and Fields, S. (1999) The PDZ domain as you like it. Nat. Biotechnol. Feb;17(2):132-3.

SenGupta, D. J., Wickens, M. and Fields, S. (1999) Identification of RNAs that bind to a specific protein using the yeast three-hybrid system. RNA Apr;5(4):596-601. download pdf