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Effects-Related Biomarkers of Environmental Neurotoxic Exposures

A Human Brain
An MRI Scan
Neurons
Receptors

The overarching goal of the UW SRP is to conduct mechanism-based laboratory research in animal models to assess neurotoxicity of neurotoxic metals and to elucidate underlying mechanisms. The outcomes we address include impaired cognition, olfaction and motor function. This research addresses important endpoints are understudied among SRP hazardous chemicals, yet they are linked to the survival of aquatic species and to human diseases, including Alzheimer's disease, Parkinson’s disease, aging associated and cognitive decline.

Based on this work, we are developing innovative biomarkers for assessing exposures, neurotoxicity, and risk susceptibility in humans and aquatic species. Cadmium, manganese and arsenic are neurotoxic metals found at Superfund hazardous waste sites that impact human health and ecosystems. Biomarkers, are enzymes, DNA changes, and other cellular chemicals that can alter physiological functions under specific conditions. These changes may predict exposure to hazardous chemicals, impaired cellular, organ or gross function, or special susceptibilities to diseases or damage from toxic agents.

 
 

     
 
 
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