Jing Zhang, MD, PhD
Acting Director, UW Medicine Neuropathology
Shaw Endowed Chair in Neuropathology
Professor of Pathology
Director, Project 3
Plasma Biomarkers for Parkisonism in Welders
Contact
E-mail: zhangj@uw.edu
Website: http://www.pathology.washington.edu/research/labs/zhang/
Mailing Address:
Harborview Medical Center
Room 2EC-09
Box 359791
Seattle, WA 98104
Research Interests
Besides being a practising neuropathologist, Dr. Zhang maintains an active research program in the area of discovering biomarkers unique to neurodegenerative disorders, e.g. Alzheimer's and Parkinson's disease. The technology utilized centers on unbiased discovery via mass spectrometry based proteomics as well as targeted validation of various novel proteins that can assist with clinical diagnosis of AD and PD or monitor disease progression. Additionally, because proteins unique to disease progression can be potential therapeutic targets, we also exploit several in vitro and in vivo models, e.g. gene manipulation and toxin-induced parkinsonian animals, to interrogate the functions of proteins revealed by proteomics analysis.
Recent publications
READCriswell SR, Perlmutter JS, Videen TO, Moerlein SM, Flores HP, Birke AM, Racette BA. Reduced Uptake of [18F]FDOPA PET in Asymptomatic Welders with Occupational Maganese Exposure. Neurology, 2011, Apr 12;76(15):1296-301.
READMontine TJ, Shi M, Quinn JF, Peskind ER, Craft S, Ginghina C, Chung KA, Kim H, Galasko DR, Jankovic J, Zabetian CP, Leverenz JB, Zhang J. CSF Abeta(42) and tau in Parkinson's disease with cognitive impairment. Mov Disorder. 2010 Sep 3.
READShi M, Zabetian CP, Hancock AM, Ginghina C, Hong Z, Yearout D, Chung KA, Quinn JF, Peskind ER, Galasko D, Jankovic J, Leverenz JB, Zhang J. Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease. Neurosci Lett. 2010 Aug 9;480(1):78-82. Epub 2010 Jun 9.
Recent presentations
Zhang J (2011, June). Proteomic studies of neurodegenerative disease. Proteomics and Aging Workshop, University of Washington, Seattle, WA.
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