UW SRP Researchers' Work

Translating Research Findings to the Public

NIEHS recognizes the importance of translating research outcomes to a variety of appropriate audiences, thereby encouraging the accurate and timely use of this research. Research Translation includes communicating scientific findings to at risk populations and community members who could benefit from this knowledge. Oftentimes this includes working with fellow scientists and government agencies that work directly with toxic sites.

In addition, research often results in the creation of novel technologies, products or approaches that can facilitate or improve site cleanup. For example University of Washington SRP researchers have developed quantitative biomarkers of exposure. These technologies have tremendous potential to improve human health and site remediation.

Researchers Topics of Investigation

Project 1: Biochemical Mechanisms of Olfactory Injury in Salmon
Dr. Evan Gallagher investigates olfactory system injury in Pacific salmon resulting from exposures to metals, with a primary focus on cadmium to understand how model Superfund neurotoxicants cause neurobehavioral impairment.

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Project 2: Cellular and Molecular Mechanisms of Cadmium Neurotoxicity
Dr. Zhengui Xia investigates mechanisms by which cadmium impairs olfaction and cognition in mice. Her research focuses on the inhibition of normal physiologic signaling in neurons in the brain that are critical for learning and memory.

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Project 3: The Role of the Paroxonases (PONs) in modulating Cadmium and Manganese Neurotoxicity
Dr. Clement Furlong and Dr. Lucio Costa employ animal models and human applications in their ongoing investigation of paroxonase protein levels. They follow both activity and genotype variations that are associated with commonly occuring neurotoxicants such as cadmium and manganese.

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Project 5: Arsenic in Shallow Unstratified and Seasonally Stratified Urban Lakes: Mobility, Bioaccumulation and Ecological Toxicity
The research of Dr. Rebecca Neumann and Dr. Jim Gawel characterizes the biogeochemical factors that control arsenic mobility and bioaccumulation in urban area lakes. The ecological and human health implications of the metalloid contamination remains unclear. The study is providing useful information on the bioavailability of arsenic in nutrient rich conditions.

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