Project 1: SRP Publications
Paraoxonases: Biomarkers of Susceptibility to Environmentally-induced Diseases


READ Cole TB, Li W-F, Co AL, Hay AM, MacDonald JW, Bammler TK, Farin FM, Costa LG, Furlong CE. 2014. Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects in maternal and fetal tissues. Toxicol Sci 141(2):409-422. PMCID: PMC4271046

READ Costa LG, de Laat R, Dao K, Pellacani C, Cole TB, Furlong CE. 2014. Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection. Neurotoxicology 43:3-9. PMCID: PMC3942372

READ Inoue S, Becker AL, Kim J-H, Shu Z, Soelberg SD, Weigel KM, Hiraiwa M, Cairns A, Lee H-B, Furlong CE, Oh K, Lee K-H, Gao D, Chung J-H, Cangelosi GA. Sensor for Rapid Detection of Mycobacterium Cells in Sputum. PLoS One. 2014; 9(1): e86018. PMCID: PMC3899086

READ Kim DS, Crosslin DR, Auer PL, Suzuki SM, Marsillach J, Burt AA, Gordon AS, Meschia JF, Nalls MA, Worrall BB, Longstreth WT Jr, Gottesman RF, Furlong CE, Peters U, Rich SS, Nickerson DA, Jarvik GP; on behalf of the NHLBI Exome Sequencing Project. 2014. Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. J Lipid Res 55(6):1173-1178. PMCID: PMC4031948

READ Kim DS, Burt AA, Rosenthal EA, Ranchalis JE, Eintracht JF, Hatsukami TS, Furlong CE, Marcovina S, Albers JJ, Jarvik GP. 2014. HDL-3 is a superior predictor of carotid artery disease in a case-control cohort of 1725 participants. J Am Heart Assoc. Jun 25;3(3):e000902. PMID: 24965026

READ Marsillach J, Suzuki SM, Richter RJ, McDonald MG, Rademacher PM, MacCoss MJ, Hsieh EJ, Rettie AE, Furlong CE. 2014. Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase. PLoS One 15;9(10):e110054. PMCID: PMC4198189


READCosta LG, Tait L, de Laat R, Dao K, Giordano G, Pellacani C, Cole TB, Furlong CE. Modulation of Paraoxonase 2 (PON2) in Mouse Brain by the Polyphenol Quercetin: A Mechanism of Neuroprotection? Neurochem Res. 2013 Sep;38(9):1809-18. PMCID: PMC3735620.

READCosta LG, de Laat R, Dao K, Pellacani C, Cole TB, Furlong CE. Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection. Neurotoxicology. 2013 Sep 4. PMCID: PMC3942372

READCosta LG, Giordano G, Cole TB, Marsillach J, Furlong CE. Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity. 2013:.. 307:1152-22. Toxicology. PMCID: PMC3516631

READGiordano G, Tait L, Furlong CE, Cole TB, Kavanagh TJ, Costa LG. Gender Differences In Brain Susceptibility To Oxidative Stress Are Mediated By Levels Of Paraoxonase-2 (Pon2) Expression. Free Radic Biol Med. 2013. PMID: 23376469. NIHMSID# 441268

READMarsillach J, Hsieh EJ, MacCoss MM, Costa LG, Furlong CE. Protein adducts as biomarkers of exposure to organophosphorus compounds. Toxicology. 2013;307:46-54. PMID: 23261756 [PubMed - in process] NIHMS: 437769

READWang, L. and E. Gallagher. 2013. Role of Nrf2 in cadmium-mediated oxidative injury to the zebrafish olfactory system. Toxicol. Appl. Pharmacol. 266(2):177-86. PMID: 23174481 NIHMSID# 429170 PMC Journal In Process


READBaker PE, Cole TB, Cartwright M, Suzuki SM, Thummel KE, Lin YS, Co AL, Rettie AE, Kim JH, Furlong CE. Identifying safer anti-wear triaryl phosphate additives for jet engine lubricants. 2012 Oct 22. Chem Biol Interact. PMID 23085349. NIHMSID# 422056

READCole TB, Fisher JC, Burbacher TM, Costa LG, Furlong CE. Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon. Neurotoxicology and Teratology 2012; 34:311-322. PMCID: PMC3367041

READMarsillach J, Hsieh EJ, Richter RJ, Maccoss MJ, Furlong CE. Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures. Chem Biol Interact. 2012 Nov 2. PMID: 23123252 [PubMed - in process]


READ Cole TB, Beyer RP, Bammler TK, Park SS, Farin FM, Costa LG, Furlong CE. Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression. Toxicol Sci. 2011 Sep;123(1):155-69. PMCID: PMC3164442.

READCosta LG, Giordano G, Furlong CE. Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on. Biochem. Pharmacol. 2011; 81: 337-344. PMCID: PMC3077125

READGiordano G, Cole TB, Furlong CE, Costa LG. Paraoxonase 2 (PON2) in the mouse central nervous system: A neuroprotective role? 2011. Toxicol Appl Pharmacol. 256(3):369-78. PMCID: PMC3155737


READCole TB, Jansen K, Park S, Li WF, Furlong CE, Costa LG. The Toxicity of Mixtures of Specific Organophosphorus (OP) Compounds is Modulated by Paraoxonase 1 (PON1) Status. 2010. Adv Exp Med Biol 660:47-60. PMCID: PMC3035621.

READFurlong CE, Suzuki SM, Stevens RC, Marsillach J, Richter RJ, Jarvik GP, Checkoway H, Samii A, Costa LG, Griffith A, Roberts JW, Yearout D, Zabetian CP. Human PON1, a biomarker of disease and exposure. Chem Biol Interact 2010;187;355-61. PMCID: PMC3035622

READ Hofmann JN, Keifer MC, De Roos AJ, Fenske RA, Furlong CE, van Belle G, Checkoway H. Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington state. Occup Environ Med 2010 Jun;67:375-386.

READSuzuki SM, Stevens RC, Richter RJ, Cole TB, Park S, Otto TC, Cerasoli DM, Lenz DE, Furlong CE. Engineering Human PON1 in an E. coli Expression System. 2010. Adv Exp Med Biol 660:37-45. PMCID: PMC3056878


READ Hofmann JN, Furlong CE, Farin FM, et al. Serum cholinesterase inhibition in relation to paraoxonase (PON1) status among organophosphate-exposed agricultural pesticide handlers. EHP 2009 2009 Sep;117(9):1402-8.

READJansen KL, Cole TB, Park SS, Furlong CE, Costa LG. 2009. Paraoxonase 1 (PON1) Modulates the Toxicity of Mixed Organophosphorus Compounds. Toxicol Appl Pharmacol. 236:142-153. PMCID: PMC2717945

READRichter RJ, Jarvik GP, Furlong CE. 2009. Paraoxonase 1 (PON1) status and substrate hydrolysis. Toxicol Appl Pharmacol 235:1-9. PMCID: PMC3045428


READ Costa LG, Cole TB, Jansen, KL, Furlong CE. 2008. Paraoxonase (PON1) and organophosphate toxicity. In: The Paraoxonases: Their Role In Disease, Development And Xenobiotic Metabolism, B Mackness, M Mackness, M Aviram and G Paragh eds. Springer, Dordrecht, The Netherlands, pp. 209-220

READ Furlong CE, Richter RJ, Li W-F, Brophy VH, Carlson C, Meider M, Nickerson D, Costa LG, Ranchalis J, Lusis AJ, Shih DM, Tward A, Jarvik GP. 2008. The functional consequences of polymorphisms in the human PON1 gene. In: The Paraoxonases: Their Role In Disease, Development And Xenobiotic Metabolism, B Mackness, M Mackness, M Aviram and G Paragh eds. Springer, Dordrecht, The Netherlands, pp. 267-281

READ Furlong CE. 2008. The Bert La Du Memorial Lecture: Paraoxonases: an historical perspective. In: The Paraoxonases: Their Role In Disease, Development And Xenobiotic Metabolism, B Mackness, M Mackness, M Aviram and G Paragh eds. Springer, Dordrecht, The Netherlands, pp. 3-31.

READRichter RJ, Jarvik GP, Furlong CE. 2008. Determination of Paraoxonase 1 Status without the Use of Toxic Organophosphate Substrates. Circ Cardiovasc Genet 1:147-152. PMCID: PMC3035628. See also editorial: Loscalzo J. Paraoxonase and coronary heart disease risk language misleads, linkage misinforms, function clarifies. PMID: 20031548

READStevens RC, Suzuki SM, Cole TB, Park SS, Richter RJ, Furlong CE. 2008. Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning. Proc Natl Acad Sci U S A. 105(35):12780-4. Epub 2008 Aug 18. See also commentary: Chambers JE, PON1 multitasks to protect health. Proc Natl Acad Sci USA 105(35): 1239-1240. PMCID: PMC2529096


Costa LG. 2007. Toxic effects of pesticides. IN: Casarett and Doull’s Toxicology. The Basic Science of Poisons. 7th Edition. CD Klaassen ed. McGraw-Hill, New York, NY

READ Furlong CE. 2007 Genetic variability in the cytochromes P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds. J Biochem Mol Toxicol 21:197- 205.

READ Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG. 2007. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicol Appl Pharmacol ; 219: 181-189.


READ Carlson CS, Heagerty PJ, Hatsukami TS, Richter RJ, Ranchalis J, Lewis J, Bacus TJ, McKinstry LA, Schellenberg GD, Rieder M, Nickerson D, Furlong CE, Chait A, Jarvik GP. 2006. TagSNP analyses of the PON gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and vascular disease. J Lipid Res 47(5):1014-24.

Costa LG, Cole TB, Furlong CE. 2006. Gene-environment interactions: paraoxonase (PON1) and sensitivity to organophosphate toxicity. Lab Med ; 37: 1-5.

READ Costa LG. 2006. Current issues in organophosphate toxicology. Clin. Chim. Acta 2006; 366:1-13.

Costa LG, Cole TB, Vitalone A, Furlong CE. Paraoxonase polymorphisms and toxicity of organophosphates. IN: Toxicology of Organophosphate and Carbamate Pesticides. RC Gupta ed. Elsevier, Burlington, MA; pp. 247-256.

Costa LG, Cole TB, Geiss GK and Furlong CE. 2006. Chapter 8. Paraoxonase, butyrylcholinesterase, and epoxide hydrolase. Costa LG and Eaton, DL, Gene-Environment Interactions: Fundamentals of Ecogenetics, John Wiley & Sons, Hoboken, NJ.

READ Furlong C, Holland N, Richter R, Bradman A, Ho A, and B Eskenazi. 2006. PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity. Pharmacogenetics and Genomics. 16:183-190.

© 2007-2015 Department of Environmental and Occupational Health Sciences, University of Washington