Project 2: SRP Publications
Parkinsonism and Metal Exposures Among Welders


READ Lundin JI, Ton TG, LaCroix AZ, Longstreth WT, Franklin GM, Swanson PD, Smith-Weller T, Racette BA, Checkoway H.  Formulations of hormone therapy and risk of Parkinson's disease.  Mov Disord. 2014;29:1631-6. PMCID: PMC4216612

READ Searles Nielsen S, Checkoway H, Criswell S, Farin F, Racette B.  Inducible nitric oxide synthase gene methylation and parkinsonism in manganese-exposed welders. Occup Environ Med. 2014;71 Suppl 1:A32. PMID: 25018322

READ Searles Nielsen S, Checkoway H, Criswell S, Farin F, Stapleton P, Sheppard L, Seixas N, Lundin J, Racette B.  Methylation of the divalent metal transporter-1 gene and parkinsonism in manganese-exposed welders.

READ Searles Nielsen S, Checkoway H, Zhang J, Hofmann JN, Keifer MC, Paulsen M, Farin FM, Cook TJ, Simpson CD.  Blood α-synuclein in agricultural pesticide handlers in central Washington State.  Environ Res. 2015 Jan;136:75-81.  PMID: 25460623.


READ Lock EA, Zhang J, Checkoway H. Solvents and Parkinsonís disease: a systematic review of toxicological and epidemiological evidence. Toxicol Appl Pharmacol 2013;266:345-55. PMCID: PMC3621032

Searles Nielsen S, Checkoway H, Nelson H, et al. Long interspersed nuclear element (LINE-1) DNA methylation profiles and interactions with smoking in Parkinson disease cases and controls. J Parkin Dis, in press.

READ Searles Nielsen S, Bammler TK, Gallagher LG, Farin FM, Longstreth Jr WT, Franklin GM, Swanson PD, Checkoway H. Genotype and age at Parkinson disease diagnosis. International Journal of Molecular Epidemiology and Genetics, 2013, 4:61-9. PMCID:PMC3612455


READCriswell S, Perlmutter J, Huang J, Golchin N, Flores H, Hobson A, Aschner M, Erikson K, Checkoway H, Racette B. Basal ganglia intensity indices and diffusion weighted imaging inmanganese exposed welders. Occup Environ Med. 2012. March 23 [epub ahead of print]

READ Lin X, Cook TJ, Zabetian CP, Hwang H, Leverenz JB, Peskind ER, Hu S-C, Cain K, Pan C, Edgar JS, Goodlett DR, Racette BA, Checkoway H, Montine TJ, Shi M, Zhang J. DJ-1 isoforms in whole blood: potential markers for Parkinson disease diagnosis and progression. Sci Rep. 2:954, 2012 PMCID: PMC3518819

READMata IF, Checkoway H, Hutter CM, Samii A, Roberts JW, Kim HM, Agarwal P, Pastor P, Yearout D, Martinez E, Farin FM, Wan JY, Edwards KL, Zabetian CP, et al. Common variation in the LRRK2 gene is a risk factor for Parkinson's disease. Mov Disord. 2012 Oct 31. PMCID: PMC3536918

READ Racette BA, Criswell S, Lundin JL, Hobson A, Seixas N, Kotzbauer PT, Evanoff BA, Perlmutter JS, Zhang J, Checkoway H. Increased risk of parkinsonism associated with welding exposure. NeuroToxicol 2012;33:1356-61. PMCID: PMC3651999

Searles Nielsen S, Checkoway H, Butler RA, Nelson HH, Farin FM, Longstreth WT Jr, Franklin GM, Swanson PD, Kelsey KT. LINE-1 DNA Methylation, Smoking and Risk of Parkinsonís Disease. J Parkinsons Dis. 2012; 2:303-308. NIHMSID# 457710

READ Searles Nielsen S, Gallagher LG, Lundin JL, Longstreth WT, Powers KM, Smith-weller T, Franklin GM, Swanson PD, Checkoway H. Environmental tobacco smoke and Parkinson disease. Mov Disord 2012;27:293-297.


READ Harris RC, Lundin JI, Criswell SR, Hobson A, Swisher LM, Evanoff BA, Checkoway H, Racette BA. Effects of parkinsonism on health status in welding exposed workers. 2011 Nov; 17(9):672-6.

READ Criswell SR, Perlmutter JS, Videen TO, Moerlein SM, Flores HP, Birke AM, Racette BA. 2011. Reduced Uptake of [18F]FDOPA PET in Asymptomatic Welders with Occupational Manganese Exposure. Neurolog. 2011 Apr 12;76(15):1296-301.


READ Firestone JA, Powers KM, Smith-Weller T, Franklin GM, Swanson PD, Longstreth WT Jr, Checkoway H. Occupational risk factors for Parkinson’s disease: a population-based case-control study. Am J Ind Med 2010 Mar;53:217-223.

READ Furlong CE, Suzuki SM, Stevens RC, Marsillach J, Richter RJ, Jarvik GP, Checkoway H, Samii A, Costa LG, Griffith A, Roberts JW, Yearout D, Zabetian CP. Human PON1, a biomarker of disease and exposure. Chem Biol Interact 2010;187;355-61. PMCID: PMC3035622

READ Hofmann JN, Checkoway H , Borges O, Servic F, Fenske RA, Keifer MC. Development of a computer-based survey instrument for organophosphate and N-methyl-carbamate exposure assessment among agricultural pesticide handlers. Ann Occup Hyg 2010 Aug;54:640-650.

READ Hofmann JN, Keifer MC, De Roos AJ, Fenske RA, Furlong CE, van Belle G, Checkoway H. Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington state. Occup Environ Med 2010 Jun;67:375-386.


READ Hobson A, Sterling DA, Emo B, Evanoff B, Sterling C, Good L, Seixas N, Checkoway H, Racette B. Validity and reliability of an occupational exposure questionnaire for parkinsonism in welders. J Occup Environ Health 2009;6 (6):324-331.

Racette BA, Criswell SR, Hobsen A, Lundlin J, Seixas N, Evanoff BA, Sterling D, Checkoway H. Prevalance of Parkinsonism in a Work-Site based Welder Cohort: A Preliminary Report. International Commission on Occupational Health, March 2009.

READ Hofmann JN, Keifer MC, Furlong CE, De Roos AJ, Farin FM, Fensle RA, van Belle G, Checkoway H. Serum cholinesterase inhibition in relation to paraoxonase (PON1) status among organophosphate-exposed agricultural pesticide handlers. Environ Health Perspect 2009;117:1402-8. PMID: 19750105 PMCID: PMC2737017


READ Costa-Mallen P, Checkoway H, Zabetian C, et al. 2008. The functional polymorphism of the hemoglobin-binding haptoglobin influences susceptibility to Parkinson’s disease. Am J Med Genet (B);147:216-222.

READ Powers KM, Smith-Weller T, Franklin GM, Longstreth WT, Jr., Swanson PD, Checkoway H. 2008. Dietary fats, cholesterol and iron as risk factors for Parkinson’s disease. Parkinson Relat Disord Apr 17


READ Ritz B, Ascherio A, Checkoway H, Marder KS, Nelson LM, Rocca WA, Ross GW, Strickland D, Van Den Eeden SK, Gorell J. 2007. Pooled analysis of tobacco use and Parkinson’s disease. Arch Neurol; 64:990-997.

READ Ton TG, Heckbert SR, Longstreth WT, Rosssing MA, Kukull WA. Franklin GM, Swanson PD, Smith-Weller T, Checkoway H. 2007. Calcium channel blockers and beta-blockers in relation to Parkinson’s disease. Parkinsonism Relat Disord ;13:165-169.


READ Kelada SNP, Checkoway H, Kardia LR, et al. 2006. 5’ and 3’ Region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson’s disease risk: a hypothesis generating study. Hum Molec Genet; 15:3055-3062.

READ Maraganore DM, de Andrade M, Elbaz A, Farrer M, Ionnidis JP, Kruger R, Rocca WA, Schneider NK, Lesnick TG, Lincoln SJ, Hulihan MM, Aasly JO, Ashizawa T, Chartier-Harlin MC, Checkoway H, et al. 2006. Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson’s disease. JAMA; 296:661-670.

READ Powers KM, Smith-Weller T, Franklin GM, Longstreth WT Jr., Swanson PD, Checkoway H. 2006. Reduced risk of Parkinson’s disease among diabetics. Parkinson Relat Disord.;12:185-189.

READ Ton TG, Heckbert SR, Kukull WA, Longstreth WT Jr., Franklin GM, Swanson PD, Smith-Weller T, Checkoway H. 2006. Aspirin, other non-steroidal anti-inflammatory drugs, and risk of Parkinson’s disease. Mov Disord;21:964-969.

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