Project 4: SRP Publications
Biotransformation gene-environment interactions in salmon neurotoxicity


READ Hook, S., Gallagher, E. and G. Batley. 2014. The Role of Biomarkers in the Assessment of Aquatic Ecosystem Health. Integrated Environmental Assessment and Monitoring. Epub 2014 May 12. PMID: 24574147

READ Maryoung, L., Lavado, R., and D. Schlenk. 2014. Impacts of hypersaline acclimation on the acute toxicity of the organophosphate chlorpyrifos to salmonids. Aquat. Toxicol. 152:284-90. PMID: 24799192


READEspinoza, M., Shireman, L., McClain, V., Atkins, W., and Gallagher E. 2013. Cloning, expression and analysisfunction of olfactory glutathione S-transferases from Coho salmon. Biochem. Pharmacol. 85:839-48. PMCID: PMC3660137

READLavado R, Aparicio-Fabre R, Schlenk D. Effects of salinity acclimation on the expression and activity of Phase I enzymes (CYP450 and FMOs) in coho salmon (Oncorhynchus kisutch). Fish Physiol Biochem. 2013 Aug 8. [Epub ahead of print] PMID: 23925894

READLavado R, Aparicio-Fabre R, Schlenk D. Effects of salinity acclimation on the pesticide-metabolizing enzyme flavin-containing monooxygenase (FMO) in rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol C Toxicol Pharmacol. 2013 Jan;157(1):9-15. doi: 10.1016/j.cbpc.2012.08.004. Epub 2012 Sep 6. PMID: 22981832 PMCID: PMC3508337

READWang L, Bammler TK, Beyer RP, Gallagher E. Copper-Induced Deregulation of microRNA Expression in the Zebrafish Olfactory System. Environ Sci Technol. 2013; 47:7466-74. PMID:23745839

READWang, L. and E. Gallagher. 2013. Role of Nrf2 in cadmium-mediated oxidative injury to the zebrafish olfactory system. Toxicol. Appl. Pharmacol. 266(2):177-86. PMID: 23174481 NIHMSID# 429170 PMC Journal In Process

READWilliams, C., Espinoza, M. and Gallagher E. 2013. Molecular biomarkers of cadmium olfactory injury in Coho salmon. Aquatic Toxicol. July 11, 2013, 295-302. PMID: 23851056


READEspinoza, M. and Gallagher E. 2012. Effect of cadmium on glutathione S-transferase and metallothionein gene expression in coho salmon olfactory, liver and gill tissues. Aquat. Toxicol. 110-111:37-44. PMCID: PMC3321375

READMcClain, V., Stapleton, H.M, Tilton, F., and Gallagher E. 2012. BDE 49 is a developmental toxicant in zebrafish. Comp. Biochem. Physiol. Part C. 155(2) 253-258. PMCID: PMC3246048

READWang, L., Harris, S., Espinoza, M., McClain, V. and Gallagher E. 2012. Characterization of phospholipid hydroperoxide glutathione metabolizing peroxidase (gpx4) isoforms in Coho salmon olfactory and liver tissues and their modulation by cadmium. Aquat. Toxicol. 114-115:134-41. PMCID: PMC3660139


READ Lavado R and Schlenk D. 2011 Microsomal biotransformation of chlorpyrifos, parathion and fenthion in rainbow trout (Oncorhynchus mykiss) and coho salmon (Onchorynchus kisutch): Mechanistic insights into interspecific differences in toxicty. Aquatic Toxicol. 101:57-63.

READ Lavado R, Maryoung K, and Schlenk D. 2011. Hypersalinity Acclimation Increases the Toxicity of the Insecticide Phorate in Coho Salmon (Onchorynchus kisutch). Envr Sci and Technol. 45:4623-4629.

READ Tilton F, Tilton S, Stapleton P, Bammler T, Beyer R, Scholz N, Gallagher E. 2011. Transcriptional impact on organophosphate and metal mixtures on olfaction: Copper dominates the chlorpyrifos-induced response in adult zebrafish. Aquatic Toxicology. 2011 Apr;102(3-4):205-15. PMID: 21356183. NIHMSID# 263060

READ Tilton FA, Bammler TK, Gallagher EP. Swimming impairment and acetylcholinesterase inhibition in zebrafish exposed to copper or chlorpyrifos separately, or as mixtures. Comp Biochem Physiol C Toxicol Pharmacol. 2011 Jan;153(1):9-16. PMCID: PMC3034093.


READ Browne. E, Kelly, M. Zhou, G.D., He, L.Y., McDonald, T., Wang, S., Duncan, B., Meador, J., Donelly, K., and Gallagher E. 2010. In situ biomonitoring of juvenile Chinook salmon (Onchorhynchus tshawytscha) using biomarkers of chemical exposures and effects in an urbanized waterway of the Puget Sound, WA. Environmental Research. 110(7):675-83.

READShao, J., White, C., Dabrowski, M., Kavanagh, T. and Gallagher E. 2010. Flow cytometry analysis of BDE 47 mediated injury to rainbow trout gill epithelial cells. Aquatic toxicology. 97:42-50. PMCID: PMC3321377


READ Lefebvre KA, Bammler TK, Farin FM, Gallagher E, et al. Gene expression profiles in zebrafish brain after acute exposure to domoic acid at symptomatic and asymptomatic doses. Tox Sci 2009 Jan;107(1):65-77.

READ Browne, E., Stapleton, H., Kelly H., Tilton, S. and Gallagher, E. 2009. In vitro hepatic metabolism of 2, 2',4,4',5-pentabromodiphenyl ether (BDE 99) in Chinook Salmon (Onchorhynchus tshawytscha). Aquatic Toxicology. 92(4):281-287.


READGallagher, E., LaVire, H., Stapleton, P., Bammler, T, Beyer, D., and F. Farin. 2008. Expression profiling of hepatic genes in smolting and adult coho salmon (Onchorhynchus kisutch). Environmental Research. 106(3):365-78.

READMatsuo, A., Li, Q., Gallagher, E., Trute, M., Janssen, P. and D.R Schlenk. 2008. Characterization of liver phase I biotransformation enzymes in coho salmon. Comp Biochem. Physiol C. 147(1):78-84.

READMcIntyre, J., Baldwin, D.H., Meador, J.P., and Scholz, N.L. 2008. Chemosensory deprivation in juvenile coho salmon exposed to dissolved copper under varying water chemistry conditions. Environmental Science and Technology. 42(4):1352-8.

READRodriguez-Fuentes, G., Aparicio-Fabre, R., Li, Q., Schlenk, D. 2008. Osmotic regulation of Flavin-containing monooxygenases in primary cultured cells from rainbow trout (Oncorhynchus mykiss). Drug Metab. Disp. 36(7):1212-7.

READ Tilton F, Tilton SC, Bammler TK, Beyer RP, Farin F, Stapleton PL, and. Gallagher EP. Transcriptional Biomarkers and Mechanisms of Copper-Induced Olfactory Injury in zebrafish. Environ. Sci. Technol. 2008, 42, 94049411. PMCID: PMC3321378


READGallagher E, Huisden, C., and J. Gardner. 2007. Transfection of HepG2 cells with hGSTA4 provides protection against 4-hydroxynonenal-mediated oxidative injury. Toxicology In vitro.21:1365-1372. PMCID: PMC2785086

READSteiner, C., Peters, W.H.M., Gallagher, E.P. and B L. Pool-Zobel. 2007. Genistein protects human mammary epithelial cells from benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide and 4-hydroxy-2-nonenal genotoxicity by modulating the glutathione/glutathione S- transferase system. Carcinogenesis. 28:738-748. PMID: 17065199

READ Trute, M., Gallus, B., Goodlett, D. and Gallagher, E. 2007. Glutathione S-transferase isozyme expression in coho salmon liver. Aquatic Toxicology. 81:126-136.

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