Centers / Allergy & Inflammation

Dr. Henderson is Director of the University of Washington Allergy and Immunology Training Program. Dr. Henderson conducts research on mast cell and eosinophil biology and function and their formation of leukotrienes potent 5-lipoxygenase products of arachidonic acid metabolism. Current research examines the pathogenesis of asthma. A murine model of asthma in which allergic airway inflammation, remodeling, and hyperreactivity develop has been established in Dr. Henderson's laboratory. Specific goals are to define by gene activation key mechanisms (eicosanoids, Th1/Th2 cytokines, adhesion molecules) in the development and maintenance of allergic pulmonary disease. Immunologic, biochemical, and molecular biologic approaches are employed in these studies with a focus on functional genomics and proteomics.