Labs / Bornfeldt Lab
People with type 1 or type 2 diabetes have a greater risk of developing cardiovascular disease (myocardial infarction, stroke, and peripheral cardiovascular disease that can lead to the necessity to amputate limbs) caused by atherosclerosis. These complications also develop earlier in life than in people without diabetes. Risk factors for cardiovascular disease associated with diabetes include sub-optimal metabolic control and lipid abnormalities, such as increased levels of triglycerides and decreased levels of HDL. Our work focuses on understanding the mechanisms of diabetes-accelerated atherosclerosis so that these complications can be treated or prevented.