Labs / Heinecke Lab

Jay W. Heinecke, M.D.
Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
UW School of Medicine at SLU
815 Mercer Street
Seattle WA 98109

Research in the Heinecke laboratory focuses on understanding the role of macrophages in the pathogenesis of atherosclerosis, obesity, and insulin resistance. Major efforts focus on using a proteomics approach to identify specific proteins targeted for oxidative modifications and building a systems biology view of the macrophage. Current studies include:

  • Investigating oxidative pathways that regulate the cardioprotective activities of high-density lipoprotein (HDL), which are of central importance in atherosclerosis
  • Use of animals with genetically engineered deficiencies to understand the role of oxidants and proteases in the pathogenesis of vascular disease and obesity
  • Identifying macrophage and dendritic cell protein networks involved in immune function and atherogenesis
  • Translational studies exploring the links between the HDL proteome, the macrophage proteome, and susceptibility to cardiovascular disease.

Fellowship, University of Washington, Division of Metabolism, Endocrinology and Nutrition, Seattle, WA M.D., Washington University, Department of Medicine, St. Louis, MO

Jay Heinecke, MD, is a Professor in the Department of Medicine and a member of the Molecular and Cellular Biology Graduate Program. He holds the Karasinski Chair in Metabolic Research and serves as Director of the Mass Spectrometry Resource (Department of Medicine).

Heinecke earned his M.D. degree from Washington University in St. Louis in 1981 and then came to the UW for a residency in internal medicine. He was also a postdoctoral fellow in the Division of Metabolism, Endocrinology and Nutrition and then a senior fellow in the UW Department of Biochemistry from 1987 until 1990. He was a faculty member at Washington University in St. Louis from 1991 until 2002, when he was professor of medicine and professor of molecular biology and pharmacology there. In 2002, he returned to the UW to take his current position. He also directs the Mass Spectrometry Resource in the Department of Medicine and is an attending physician at UW Medical Center.

He has received numerous awards, including the American Heart Association's Jeffrey M. Hoeg Arteriosclerosis, Thrombosis and Vascular Wall Biology Award in 2001 and an Excellence in Mentoring Award from the Washington University Graduate Student Senate in 2002. He is a member of several editorial boards, including the Journal of Clinical Investigation, the Journal of Lipid Research and the Journal of Biological Chemistry.