The following data are part of a homozygosity mapping study of Werner's syndrome here at UW. Werner's syndrome is a very rare recessive trait of premature aging. The allele frequency is less than 0.005. All the individuals listed below are affected and all are offspring first-cousin marriages. As far as is known, the families are not related, but 641 and 642 are sibs, as also are 1541 and 1542. All these families are from the Japanese part of the study population. Also given here are the marker genotypes at the ApoB locus. ApoB is on chromosome 2 and is unlinked to the Werner's syndrome locus, which is now known to be on chromosome 8. ApoB allele frequencies are given at the bottom of this file. The five columns of data are: subject id, sex (1 = male, 2 = female), disease status (1 = affected), and the marker genotype at the ApoB locus: 141 2 1 1 2 241 2 1 3 3 341 2 1 1 3 441 2 1 1 1 541 1 1 1 1 642 2 1 4 1 641 2 1 4 1 741 2 1 4 1 841 1 1 4 1 941 1 1 1 5 1041 2 1 1 1 1141 2 1 3 5 1241 2 1 4 4 1358 2 1 1 1 1442 1 1 1 1 1542 1 1 1 6 1541 2 1 1 6 1641 1 1 7 7 1742 2 1 4 1 1741 2 1 4 1 1941 2 1 1 1 Some alleles for APOB are quite different in frequency in the Japanese as compared to Caucasians. Initially, Caucasian frequencies were used in the analysis, as these are more readily available from a larger control sample of individuals. The following are Marker allele frequencies: allele Large stadard sample UW study control samples N=250 N=60 N=152 Caucasian Caucas. Japanese 1 0.2190 0.2000 0.6382 2 0.0776 0.0333 0.0263 3 0.4020 0.4667 0.1250 4 0.0500 0.0500 0.1184 5 0.0756 0.0833 0.0263 6 0.0378 0.0667 0.0132 7 (0.0294) If Caucasian frequencies are used, some indications of linkage are found: although a lod score of 3 is not achieved, an "interesting" lod score of over 2 is obtained. However, when following up with the correct Japanese frequencies, the maximum lod score is under 1.