June 18, 2010 |
Susan Fung |
Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation.
E. Romero-Sandoval....J. DeLeo. Mol Pain 5:1-15, 2009.
|
April 9, 2010 |
Eric Horne |
Self-modulation of neocortical pyramidal neurons by endocannabinoids.
S. Marinelli....A. Bacci. Nature Neurosci 12:1488-90, 2009.
|
March 26, 2010 |
Will Marrs |
The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase a mediates retrograde suppression of synaptic transmission.
A. Tanimura….M. Kano. Neuron 65:320-27, 2010.
|
March 12, 2010 |
Michelle Sexton |
Anti-inflammatory properties of CB1 receptor antagonist involves beta2 adrenoceptors.
SJ Mnich….S. Muthian. J Pharmacol Exp Ther. 2010 Feb. 17, 2010 [Epub ahead of print].
|
February 26, 2010 |
Nephi Stella |
Molecular reconstruction of mGluR5a-mediated endocannabinoid signaling cascade in single rat sympathetic neurons.
Y.J. Won….S.R. Ikeda. J Neurosci 29:13603–12, 2009.
|
February 12, 2010 |
Yi Hsing Lin |
Inhibition of spontaneous neurotransmission in the nucleus of solitary tract of the rat by the cannabinoid agonist WIN 55212-2 is not via CB1 or CB2 receptors.
D. Accorsi-Mendonca....R.M. Leao. Brain Res 1200:1-9, 2008.
|
January 15, 2010 |
Susan Fung |
Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances.
Y. Ren….Y. Hurd. J Neurosci 29:14764-69, 2009.
|
December 18, 2009 |
Eric Horne |
Altered surface trafficking of presynaptic cannabinoid type 1 receptor in and out synaptic terminals parallels receptor desensitization.
L. Mikasovaa….O.J. Manzonia. PNAS 105:18596-601, 2008.
|
December 4, 2009 |
Guest Speaker: Christine Lee |
Development and preliminary validation of a comprehensive marijuana motives questionnaire.
C. Lee….J.R. Grossbard. J Stud Alcohol Drugs 70:279-87, 2009.
|
November 6, 2009 |
Will Marrs |
Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling.
E. Puighermanal....A. Ozaita. Nature Neurosci 12:1152-60, 2009.
|
October 9, 2009 |
Michelle Sexton |
Plasma endocannabinoid levels in multiple sclerosis.
L. Jean-Gilles….C.S. Constantine. J Neurol Sci (2009) doi:10.1016/j.jns.2009.07.021.
|
September 11, 2009 |
Nephi Stella |
Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington’s disease.
M.J. Dowie….M. Glass. Neuroscience 163:456-465, 2009.
|
June 19, 2009 |
Jackie Blankman from the Cravatt laboratory at Scripps |
Seminar: “Enzymatic Degradation of the Endocannabinoid 2-arachidonoylglycerol”
|
May 8, 2009 |
Eiron Cudaback |
Cannabinoid action induces autophagymediated cell death through stimulation of ER stress in human glioma cells.
M. Salazar….G. Velasco. J Clin Invest 119:1359-72, 2009.
|
April 10, 2009 |
Yi Hsing Lin |
Lipid G-protein-coupled receptor ligand identification using beta–arrestin pathhunter assay.
H. Yin....Y.A. Chen. J Biol Chem March 13, 2009 [Epub ahead of print].
|
March 27, 2009 |
Will Marrs |
Identification of intracellular carriers for the endocannabinoid anandamide.
M. Kaczochaa....D.G. Deutsch. PNAS March 23, 2009 (Epub ahead of print).
|
March 13, 2009 |
Eric Horne |
Genetic dissection of behavioural and autonomic effects of Δ9-tetrahydrocannabinol in mice.
K. Monory…G. Marsicano. PLoS Biol 5:e269, 2007.
|
February 27, 2009 |
Faith Reyes |
Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels.
D. Ryan….B. Platt. J Neurosci 29:2053-63, 2009.
|
January 30, 2009 |
Michelle Sexton |
The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis.
J. Palazuelos....I.Galve-Roperh. J Biol Chem 283:13320-9, 2008.
|
January 16, 2009 |
Nephi Stella |
Modulation of the balance between cannabinoid CB1 and CB2 receptor activation during cerebral ischemic/reperfusion injury.
M. Zhang....R.F. Tuma. Neuroscience 152:753-760, 2008.
|
December 5, 2008 |
Eiron Cudaback |
Ligand-binding architecture of human CB2 cannabinoid receptor: evidence for receptor subtype-specific binding motif and modeling gpcr activation.
Y. Pei….A. Makriyannis. Chem Biol 15:1207–1219, 2008.
|
November 7, 2008 |
Yi Hsing Lin |
Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells.
T.S. Lu….S. Avraham. J Immunol 181:6406-6416, 2008.
|
October 24, 2008 |
Nephi Stella |
Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein Gαi2ß1γ2.
K. Nickl….R. Seifert. Neurosci Letters, in press, 2008.
|
October 9, 2008 |
Will Marrs |
Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex.
M. Lafourcade....O.J. Manzoni. PLoS ONE 8(e709):1-11, 2007.
|
August 29, 2008 |
Poulami Mitra |
Loss of cannabinoid receptor 1 accelerates intestinal tumor growth.
D. Wang….R.N. DuBois. Cancer Res 68:6468–76, 2008.
|
July 18, 2008 |
Eric Horne |
Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum.
M. Uchigashima….M. Watanabe. J Neurosci 27:3663-3676, 2007.
|
June 20, 2008 |
Aaron Miller |
The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain.
P.C. Staton….I.P. Chessell. Pain May 23, 2008 (Epub ahead of print).
|
June 6, 2008 |
Faith Reyes |
Endocannabinoids mediate neuron-astrocyte communication.
M. Navarrete & A. Araque. Neuron 57:883-893, 2008.
|
May 23, 2008 |
Eiron Cudaback |
Network that triggers neurite outgrowth design logic of a cannabinoid receptor signaling.
K.D. Bromberg….R. Iyengar. Science 320:903-909, 2008.
|
May 9, 2008 |
Nephi Stella |
Activation of the endocannabinoid system by organophosphorus nerve agents.
D.K. Nomura….J.E. Casida. Nat Chem Biol, April 27, 2008 (Epub ahead of print).
|
April 11, 2008 |
Yi Hsing Lin |
Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3.
R. Rozenfeld & L.A. Devi. FASEB J. Published online March 7, 2008.
|
March 28, 2008 |
Will Marrs |
Potentiation of electrical and chemical synaptic transmission mediated by endocannabinoids.
R. Cachope….A.E. Pereda. Neuron 56:1034-1047, 2007.
|
February 29, 2008 |
Elsa Raibon |
Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicity.
P. Zhao….M.E. Abood. Eur J Neurosci 27:572-579, 2008.
|
December 21, 2007 |
Aaron Miller |
Hemopressin is an inverse agonist of CB1 cannabinoid receptors.
A.S. Heimann….L.A. Devi. PNAS 104:20588–20593, 2007.
|
December 7, 2007 |
Faith Reyes |
Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex.
F.R. Bambico....G. Gobbi. J Neurosci 27:11700–11711, 2007.
|
October 26, 2007 |
Ethan Russo |
History of cannabis and its preparations in saga, science, and sobriquet.
E.B. Russo. Chem Biodiversity 4:1614-1648, 2007.
|
October 12, 2007 |
Eiron Cudaback |
Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity.
S. Dirikoc....J. Chabry. J. Neurosci 27:9537-9544, 2007.
|
September 14, 2007 |
Nephi Stella |
Symptom-related changes of endocannabinoid and palmitoylethanolamide levels in brain areas of R6/2 mice, a transgenic model of Huntington’s disease.
T. Bisogno....V. Di Marzo. Neurochem Int, in press.
Severe deficiency of the fatty acid amide hydrolase (FAAH) activity segregates with the Huntington’s disease mutation in peripheral lymphocytes.
N. Battista....M. Maccarrone. Neurobiol Dis 27:108–116, 2007.
|
August 17, 2007 |
Michelle Sexton |
Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and –independent immunomodulatory effects.
S. Raduner….J. Gertsch. JBC 281:14192-14206, 2006.
|
July 24, 2007 |
Aaron Miller |
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.
N. Agarwal....R. Kuner. Nature Neurosci 10:870-879, 2007.
|
July 17, 2007 |
Faith Reyes |
Neuronal connectivity hardwiring the brain: endocannabinoids shape neuronal connectivity.
P. Berghuis….T. Harkany. Science 316:1212-1216, 2007.
|
July 3, 2007 |
Eiron Cudaback |
Attenuation of allergic contact dermatitis through the endocannabinoid system.
M. Karsak….A. Zimmer. Science 316:1494-1497, 2007.
|
May 22, 2007 |
Nephi Stella |
Gi protein modulation induced by a selective inverse agonist for the peripheral cannabinoid receptor CB2: implication for intracellular signalization cross-regulation.
M. Bouaboula….P. Casellas. Mol Pharmacol 55:473–480, 1999.
|
May 8, 2007 |
Tanya Daigle |
A molecular basis of analgesic tolerance to cannabinoids.
A. Tappe-Theodor….R. Kuner. J Neurosci 27:4165–4177, 2007.
|
April 24, 2007 |
Aaron Miller |
Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells.
K. Maresz….B.N. Dittel. Nat Med 13:492-497, 2007.
|
April 10, 2007 |
Faith Reyes |
The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.
J.E. Lauckner…K. Mackie. PNAS 102:19144-19149, 2005.
|
March 27, 2007 |
Eiron Cudaback |
Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury.
S. Batkai....P. Pacher. FASEB J, March 7, 2007 (Epub ahead of print).
|
March 13, 2007 |
Nephi Stella |
The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset.
J.L. Shoemaker….P.L. Prather. J Neurochem, January 4, 2007 (Epub ahead of print).
|
February 27, 2007 |
Will Marrs |
Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus.
Y. Hashimotodani.…M. Kano. J Neurosci 27(5):1211–1219, 2007.
|
January 24, 2007 |
Tanya Daigle |
The role of protein synthesis in striatal long-term depression.
H.H. Yin….D.M. Lovinger. J Neurosci 26(46):11811–11820, 2006.
|
December 19, 2006 |
Aaron Miller |
Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
R. Mathison….K. A.Sharkey. Br J Pharmacol 142:1247–1254, 2004.
Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors.
C. Rousseaux….P. Desreumaux. Nature Med, December 10, 2006 (Epub ahead of print).
|
December 5, 2006 |
Faith Reyes |
Serotonin 5-HT receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanism.
J.C. Parrish….D.E. Nichols. J Neurochem 99(4):1164-1175, 2006.
|
October 31, 2006 |
Tanya, Faith, Aaron |
Review of Society for Neuroscience 2006 Meeting.
|
October 10, 2006 |
Brady Atwood |
Serotonin 5-HT2C receptor homodimer biogenesis in the endoplasmic reticulum. real-time visualization with confocal fluorescence resonance energy transfer.
K. Herrick-Davis….J.E. Mazurkiewicz. J Biol Chem 281:27109-27116, 2006.
|
September 26, 2006 |
Nephi Stella |
A biosynthetic pathway for anandamide.
J. Liu….G. Kunos. PNAS 103:13345-13350, 2006.
|
September 12, 2006 |
Eiron Cudaback |
Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of bad to mitochondria.
W. Jia….P.S. Nagarkatti. Mol Cancer Res 4:549-562, 2006.
|
August 29, 2006 |
Chris Kearn |
Induction of KROX-24 by endogenous CB1 receptors in neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the PI3K pathway.
E.S. Graham….M. Glass. JBC Papers, July 24, 2006 (Epub ahead of print).
|
August 15, 2006 |
Giulio Muccioli |
Endocannabinoid biosynthesis proceeding through glycerophospho-n-acyl ethanolamine and a role for alpha/beta hydrolase 4 in this pathway.
G.M. Simon & B.F. Cravatt. JBC papers, July 3, 2006 (Epub ahead of print).
|
July 18, 2006 |
Jane Lauckner |
The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 F442A preadiopocytes.
M. Gary-Bobo….M. Bensaid. Mol Pharmacol 69:471-478, 2006.
|
July 5, 2006 |
Ken, Chris, Nephi |
Report on ICRS Meeting. Meet in BB1444 (Anesthesiology Library).
|
June 6, 2006 |
Ken Mackie |
Antifibrogenic role of the cannabinoid receptor CB2 in the liver.
B. Julien….S. Lotersztajn. Gastroenterology 128:742–755, 2005.
CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis.
F. Teixeira-Clerc….S. Lotersztajn. Nat Med, May 21, 2006 (Epub ahead of print).
|
May 9, 2006 |
Alex Straiker |
Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells.
L. Glickfeld & M. Scanziani. Nat Neurosci, April 30, 2006 (Epub ahead of print).
|
April 25, 2006 |
Jane Sullivan |
The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum.
Y. Kawamura….M. Kano. J Neurosci 26:2991-3001, 2006.
|
April 11, 2006 |
Brooke Kelley |
The ryanodine receptor regulates endogenous cannabinoid mobilization in the hippocampus.
M. Isokawa & B.E. Alger. J Neurophysiol, in press (February 8, 2006).
|
March 28, 2006 |
Tanya Daigle |
Constitutive activation drives compartment-selective endocytosis and axonal targeting of type 1 cannabinoid receptors.
C. Leterrier….Z. Lenkei. J Neurosci 26:3141-3153, 2006.
|
March 14, 2006 |
Aaron Miller |
Effects of peripheral cannabinoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils.
R. Kurihara….H. Yamamura. JBC Papers, in press. Published on March 2, 2006 as Manuscript M510871200.
|
February 28, 2006 |
Faith Reyes |
Cannabinoid receptor type 2 agonists induce transcription of the µ-opioid receptor gene in Jurkat T cells.
C. Börner….J. Kraus. Molecular Pharmacology Fast Forward. Published on January 24, 2006 as doi:10.1124/mol.105.018325.
|
February 14, 2006 |
Nephi Stella |
A second N-acylethanolamine hydrolase in mammalian tissues.
N. Uedaa….D.M. Lambert. Neuropharmacology 48:1079-1085, 2005.
Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase.
K. Tsuboi….N. Ueda. J Biol Chem 280:11082–11092, 2005.
|
January 31, 2006 |
Eiron Cudaback |
Peripheral cannabinoid receptor, CB2, regulates bone mass.
O. Ofek….I. Bab. PNAS 103: 696–701, 2006.
|
January 17, 2006 |
Chris Kearn |
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis.
G. Gobbi….D. Piomelli. PNAS 102:18620–18625, 2005.
|
January 3, 2006 |
Chris Hague |
Allosteric modulation of the cannabinoid CB1 receptor.
M.R. Price….R.A. Ross. Mol Pharmacol 68:1484–1495, 2005.
|
December 6, 2005 |
|
Review of Society for Neuroscience Meeting.
|
October 25, 2005 |
Jane Lauckner |
Quantum dots conjugated to Bombesin or Angiotensin II label the cognate G protein-coupled receptor in living cells.
S.H. Young, E. Rozengurt. Cell Am J Physiol Cell Physiol, October 19, 2005 (Epub ahead of print).
|
October 11, 2005 |
Ken Mackie |
Functional expression of single-chain heterodimeric G-protein-coupled receptors for adenosine and dopamine.
T. Kamiya….H. Nakata. Cell Struct Funct 29:139-145, 2005.
|
September 27, 2005 |
Alex Straiker |
Glycine receptors in CNS neurons as a target for nonretrograde action of cannabinoids.
J.A. Lopez-Moreno….M. Navarro. J Neurosci 25:7499-7506, 2005.
Species and strain differences in the expression of a novel glutamate-modulating cannabinoid receptor in the rodent hippocampus.
A.F. Hoffman….C.R. Lupica. Eur J Pharmacology, in press.
|
September 13, 2005 |
Jane Sullivan |
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus.
J.K. Makara….D. Piomelli. Nature Neurosci 8:1139-1141, 2005.
|
August 30, 2005 |
Brooke Kelley |
Δ9-tetrahydrocannbinol accounts for the antinociceptive, hypothermic, and cataleptic effects of marijuana in mice.
S.A. Varvel….A.H. Lichtman. J Pharmacol Exp Ther 314:329-337, 2005.
|
August 16, 2005 |
Tanya Daigle |
An endocannabinoid mechanism for stress-induced analgesia.
A. Hohmann….D. Piomelli. Nature 435:1108-1112, 2005.
|
June 21, 2005 |
Christopher Kearn |
Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors.
A.I. Idris….S.H. Ralston. Nat Med, May 22, 2005 (Epub ahead of print).
|
June 7, 2005 |
Alan Tseng |
Neuromodulation via conditional release of endocannabinoids in the spinal locomotor network.
P. Kettunen….A. El Manira. Neuron 45:95-104, 2005.
|
May 24, 2005 |
Anke Witting |
Endocannabinoid signaling depends on the spatial pattern of synapse activation.
P. Marcaggi & D. Attwell. Nature Neurosci, May 1, 2005 (Epub ahead of print).
|
May 10, 2005 |
Eiron Cudaback |
Identification of WIN55212-3 as a competitive neutral antagonist of the human cannbinoid CB2 receptor.
J. Savinainen….J.T. Laitinen. Br J Pharmacology, April 25, 2005 (Epub ahead of print).
|
April 26, 2005 |
Canceled |
David Greenberg from the Buck Institute will talk about "Cannabinoids, Neuroprotection and Neurogenesis" at 2:30 in T-747.
|
April 12, 2005 |
Nephi Stella |
Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice.
S. Steffens….F. Mach. Nature 434:782-786, 2005.
|
March 29, 2005 |
Mike Myoga |
Different G protein-coupled receptor kinases govern G protein and Cß-arrestin-mediated signaling of V2 vasopressin receptor.
X.R. Ren….R.J. Lefkowitz. PNAS 1448–1453, 2005.
|
March 15, 2005 |
Jane Lauckner |
Real-time monitoring of receptor and G-protein interactions in living cells.
C. Galés….M. Bouvier.
Nature Methods 2:177-184. 2005.
A FLAsH-based FRET approach to determine G protein-coupled receptor activation in living cells.
C. Hoffmann….M. Lohse.
Nature Methods 2:171-176, 2005.
|
March 1, 2005 |
Ken Mackie |
Synaptic activity augments muscarinic acetylcholine receptor-stimulated Inositol 1,4,5-Trisphosphate production to facilitate Ca2+ release in hippocampal neurons.
M.S. Nash….S.R. Nahorski. J Biol Chem 279:49036-49044, 2004.
|
February 17, 2005 |
Alex Straiker |
Phospholipase Cß serves as a coincidence detector through its Ca(2+) dependency for triggering retrograde endocannabinoid signal.
Y. Hashimotodani….M. Kano. Neuron 45:257-268, 2005.
|
February 3, 2005 |
Jane Sullivan |
Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids.
A. Bacci….D.A. Prince. Nature 431:312-316, 2004.
|
January 20, 2005 |
Christopher Kearn |
Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries.
K.M. Gauthier….W.B. Campbell. American Physiological Society, 2004.
|
January 6, 2005 |
Tanya Daigle |
Independent presynaptic and postsynaptic mechanisms regulate endocannabinoid signaling at multiple synapses in the ventral tegmental area.
A.C. Riegel & C.R. Lupica. J Neurosci 24:11070-11078, 2004.
|
December 9, 2004 |
Alan Tseng |
Effects of CB1 cannabinoid receptor blockade on ethanol preference after chronic alcohol administration combined with repeated re-exposures and withdrawals.
F. Lallemand….P. De Witte. Alcohol & Alcoholism 39:486-492, 2004.
Long-lasting increase of alcohol relapse by the cannabinoid receptor agonist WIN 55,212-2 during alcohol deprivation.
J.A. Lopez-Moreno….M. Navarro. J Neurosci 24:8245-8252, 2004.
|
November 12, 2004 |
|
Review of Society for Neuroscience Meeting.
|
October 28, 2004 |
|
Review of Society for Neuroscience Meeting.
|
October 14, 2004 |
Nephi Stella |
Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptkake.
S. Ortega-Gutierrez….B.F. Cravatt. Biochemistry 43:8184-8190, 2004.
|
September 2, 2004 |
Anke Witting |
A role for caveolae/lipid rafts in the uptake and recycling of the endogenous cannabinoid anandamide.
M. McFarland….E. Barker. JBC Papers, in press. Published on August 3, 2004 as Manuscript M407250200.
|
August 19, 2004 |
Eiron Cudaback |
Functional disassociation of the central and peripheral fatty acid amide signaling systems.
B.F. Cravatt….A.H. Lichtman. PNAS 101:10821-10826, 2004.
|
August 5, 2004 |
Mike Myoga |
Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172.
C.D. Fegley….D. Piomelli. PNAS 101:8756–8761, 2004.
RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol.
T.P. Dinh….D. Piomelli. Mol Pharmacol, July 22, 2004 (Epub ahead of print).
|
July 22, 2004 |
Jane Lauckner |
Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapse.
C. Kushmerick….H. von Gersdorff. J Neurosci 24(26):5955-5965, 2004.
|
July 8, 2004 |
|
Ken, Chris and Alex will give a summary of the new research presented at the ICRS in Naples.
|
June 10, 2004 |
Lisa Walter |
Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model.
X. Ni….R.F Tuma. Mult Scler 10:158-164, 2004.
|
May 27, 2004 |
Ken Mackie |
Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling.
Y. Fukudome….M. Kano. Eur J Neuroscience 19:2682-2692, 2004.
|
May 13, 2004 |
Christopher Kearn |
The peripheral cannabinoid receptor CB2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner.
M.A. Jorda….R. Delwel. Blood, March 23, 2004 (Epub ahead of print).
|
April 29, 2004 |
Alex Straiker |
Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study.
E. Murillo-Rodriguez….P.J. Shiromani. Sleep 26:943-947, 2003.
|
April 15, 2004 |
Tanya Daigle |
Brief synaptic bursts evoke synapse-specific retrograde inhibition mediated by endogenous cannabinoids.
S.P. Brown….W.G. Regehr. Nature Neurosci 6:1048-1057, 2003.
|
April 1, 2004 |
Alan Tseng |
Modulation of extracellular signal-regulated kinases cascade by chronic D9-tetrahydrocannabinol treatment.
T. Rubino….D. Parolaro. Mol Cell Neurosci 25:355-362, 2004.
A single in-vivo exposure to D9-tetrahydrocannabinol blocks endocannabinoid-mediated synaptic plasticity.
S. Mato….O.J. Manzoni.
|
March 18, 2004 |
Nephi Stella
|
Mouse blastocysts release a lipid which activates anandamide hydrolase in intact uterus.
M. Maccarrone….A. Finazzi-Agro.
Mol Hum Reprod. Advance Access published February 16, 2004
Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation.
H. Wang….S.K. Dey.
PNAS 100(25):14914-14919, 2003.
|
March 4, 2004 |
Ariela Gordon-Shaag
|
Gi protein activation in intact cells involves subunit rearrangement rather than dissociation.
M. Bunemann….M.J. Lohse.
PNAS 100:16077–16082, 2003.
|
February 18, 2004 |
Anke Witting
|
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.
S.E. Jordt….D. Julius.
Nature 427:260-265, 2004.
|
February 5, 2004 |
Eiron Cudaback
|
Addicting drugs utilize a synergistic molecular mechanism in common requiring adenosine and Gi-beta gamma dimmers.
L. Yao....I. Diamond.
PNAS 100:14379-14384, 2003.
|
January 22, 2004 |
Lisa Walter
|
Molecular characterization of a phospholipase D generating anandamide and its congeners.
Y. Okamoto....N. Ueda.
JBC Papers, in press, published on November 21, 2003.
|
January 8, 2004 |
Mike Myoga |
The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro.
Z. Xia....B.L. Roth.
Neurosci 122:907-920,2003.
|
November 26, 2003 |
Ken Mackie
|
Measurement of the millisecond activation switch of G protein-coupled receptors in living cells.
J.P. Vilardaga....M.J. Lohse.
Nature Biotech 21:807-812,2003.
|
October 30, 2003 |
Christopher Kearn
|
A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors.
M. Tanowitz & M. von Zastrow.
JBC Papers, in press. Published on August 25, 2003 as Manuscript M304504200.
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October 16, 2003 |
Lisa Walter
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CB1 cannabinoid receptors and on-demand defense against excitotoxicty.
G. Marsicano....B. Lutz.
Science 302:84-88, 2003.
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October 2, 2003 |
Alex Straiker
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The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy.
M.J. Wallace....R.J. Delorenzo.
JPET 307:129-137, 2003.
Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures.
K. Chen....I. Soltesz.
Neuron 39:599-611, 2003.
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August 21, 2003 |
Alan Tseng
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Membrane assembly of the cannabinoid receptor 1: impact of a long n-terminal tail
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H. Andersson....C.N. Chin.
Mol Pharmacol 64(3):570-577, 2003.
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August 7, 2003 |
Nephi Stella
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Calcium dependence of retrograde inhibition by endocannabinoids at synapses onto purkinje cells.
S.D. Brenowitz & W.G. Regehr.
J Neurosci 23(15):6373-6384, 2003.
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July 24, 2003 |
Ariela Gordon-Shaag
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Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro.
J. Ahluwalia....I. Nagy.
Eur J Neurosci 17:2611-1618, 2003.
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July 10, 2003 |
Mackie Lab |
Research presented at ICRS Meeting.
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May 29, 2003 |
Anke Witting |
Heterosynaptic LTD of hippocampal GABAergic synapses. a novel role of endocannabinoids in regulating excitability.
V. Chevaleyre & P.E. Castillo.
Neuron 38(3):461-72, 2003.
Excitement reduces inhibition via endocannabinoids.
T.F. Freund & N. Hajos.
Neuron 38(3):362-365, 2003.
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May 15, 2003 |
Eiron Cudaback |
Therapeutic action of cannabinoids in a murine model of multiple sclerosis.
A. Arevalo-Martin....C. Guaza.
J Neurosci 23(7):2511-2516, 2003.
2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism.
S. Kishimoto....T. Sugiura.
JBC Papers, in press. (Published on April 23, 2003 as Manuscript M301359200.)
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April 17, 2003 |
Lisa Walter |
Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.
M.L. Lopez-Rodriguez....J.A. Ramos.
J Med Chem 46:1512-1522, 2003.
Evidence against the presence of an anandamide transporter.
S.T. Glaser....D. G. Deutsch.
Proc Natl Acad Sci USA 100(7):4269-4274, 2003.
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April 3, 2003 |
Ken Mackie |
Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus.
P. Derkinderen....J.A. Girault.
J Neurosci 23:2371-2382, 2003.
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March 20, 2003 |
Christopher Kearn |
The effects of Delta(9)-tetrahydrocannabinol physical dependence on brain cannabinoid receptors.
C.S. Breivogel...B.R. Martin.
Eur J Pharmacol 459:139-150, 2003.
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March 6, 2003 |
Alex Straiker |
Activation of muscarinic acetylcholine receptors enhances the release of endogenous cannabinoids in the hippocampus.
J. Kim...B.E. Alger.
J Neurosci 22:10182-10191, 2002.
Metabotropic glutamate receptors drive the endocannabinoid system in hippocampus.
N. Varma...B.E. Alger.
J Neurosci 21:RC188, 2001.
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February 20, 2003 |
Jane Sullivan |
Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses.
T. Ohno-Shosaku...M. Kano.
J Neurosci 22:3864-3872, 2002.
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February 6, 2003 |
Anke Witting |
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
M.L. Casanova...M. Guzman.
J Clin Invest 111:43-50, 2003.
Inhibition of tumor angiogenesis by cannabinoids.
Cristina Blazquez...Manuel Guzman
FASEB J. Jan 2, 2003.
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January 23, 2003 |
Charles Chavkin |
Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 resolution.
M. Nishida & R. MacKinnon.
Cell 111:957-965, 2002.
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January 9, 2003 |
Nephi Stella |
Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling.
E. Molina-Holgado...C. Guaza.
J Neurosci 22:9742-9753, 2002.
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December 12, 2002 |
Eiron Cudaback |
Modulation of anxiety through blockade of anandamide hydrolysis.
S. Kathuria….D. Piomelli.
Nat Med 9(1):76-81, 2003.
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October 31, 2002 |
Ken Mackie |
Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens.
D. Robbe...O.J. Manzoni.
Proc Natl Acad Sci USA (12):8384-8, 2002.
Endocannabinoids facilitate the induction of LTP in the hippocampus.
G. Carlson...B.E. Alter.
Nat Neurosci 5(8):723-4, 2002.
Pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibers.
N. Hajos & T.F. Freund.
Neuropharmacology 43(4):503-10, 2002.
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