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Microglial Journal Club

Microglial Journal Club Photos
Schedule of Presenters for Microglial Journal Club

Meets every other Friday at Noon in Room K-250

May 13, 2011

Gwenn Garden

Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death.
J.J. Neher….G.C. Brown. J Immunol 186:4973-83, 2011.

April 1, 2011

Susan Fung

Microglia/macrophages promote glioma progression.
H. Zhai....S.E. Tsirka. GLIA 59:472–85, 2011.

March 18, 2011

Eric Horne

Caspase signalling controls microglia activation and neurotoxicity.
M.A. Burguillos….B. Joseph. Nature March 9, 2011 [Epub ahead of print].

February 18, 2011

Aurelio Silvestroni

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway.
E.D. Ponomarev….H.L. Weiner. Nature Med 17:64-70, 2011.

February 4, 2011

Thomas Möller

Fate mapping analysis reveals that adult microglia derive from primitive macrophages.
F. Ginhoux M. Merad. Science 330:841-45, 2010.

November 19, 2010

Michelle Sexton

Microglial interactions with synapses are modulated by visual experience.
M. Tremblay…..A.K. Majewska. PLoS Biology 8:1-16, 2010.

October 29, 2010

James Li

The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity.
J. Shi….K. Andreasson. J Immunol 184:7207-18, 2010.

September 17, 2010

Gwenn Garden

Central nervous system (CNS)-resident natural killer cells suppress Th17 responses and CNS autoimmune pathology.
J. Hao….F.D. Shi. J Exp Med 207:1907-21, 2010.

August 27, 2010

Susan Fung

Human microglia transplanted in rat focal ischemia brain induce neuroprotection and behavioral improvement.
D. Narantuya….S.U. Kim. PLoS ONE 5(7):1-10, 2010.

May 28, 2010

Michelle Sexton

Activated microglial cells acquire an immature dendritic cell phenotype and may terminate the immune response in an acute model of EAE.
B. Almolda....B. J Neuroimmunol, in press, 2010.

April 30, 2010

Aurelio Silvestroni

Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disorders.
C. Israelsson….T. Ebenda. Eur J Neurosci 31:852–863, 2010.

April 2, 2010

Suman Jayadev

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
C.R. Stewart….K.J. Moore. Nature Immunol 11:155-62, 2010.

March 5, 2010

Will Marrs

Adenosine A2A receptor mediates microglial process retraction.
A.G. Orr….S.F. Traynelis. Nature Neurosci 12:872-80, 2009.

February 19, 2010

Susan Fung

Microglial precursors derived from mouse embryonic stem cells.
I. Napoli....H. Neumann. Glia, 57:1660-71, 2009.

February 5, 2010

Thomas Möller

Identification of splenic reservoir monocytes and their deployment to inflammatory sites.
F.K. Swirski....M.J. Pittet. Science 325:612-16, 2009.

January 22, 2010

Nephi Stella

Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord.
K.A. Kigerl….P.G. Popovich. J Neurosci 29:13435-444, 2009.

January 8, 2010

Gwenn Garden

MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages.
A. Aziz….M.H. Sieweke. Science 326:867-71, 2009.

December 11, 2009

Yi Hsing Lin

Microglia are mediators of borrelia burgdorferi–induced apoptosis in sh-sy5y neuronal cells.
T.A. Myers….M.T. Philipp. PLoS Pathogens 5:1-15, 2009.

November 13, 2009

Eiron Cudaback

Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer’s disease.
M.I. Fonseca….A.J. Tenner. J Immunol 183:1375–83, 2009.

October 16, 2009

Eric Horne

Microglial CB2 cannabinoid receptors are neuroprotective in Huntington’s disease excitotoxicity.
J. Palazuelos....I. Galve-Roperh. Brain 1-13, October 2009.

October 2, 2009

Aurelio Silvestroni

Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo.
F.G. Pittelli....A. Chiarugi. Neurobiol Dis. 2009 Jul 25. [Epub ahead of print].

September 18, 2009

Michelle Sexton

Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice.
R. Shechter....M. Schwartz. PLoS Med 6(7):e1000113, July 2009.

July 24, 2009

Guest Speaker

Jonathan Wisor, Assistant Professor, Washington State University, Spokane, WA.
Microglial and Sleep.

June 26, 2009

Will Marrs

Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine.
S. Rosi….C.A. Barnes. Brain Advance Access published June 16, 2009.

May 15, 2009

Elsa Raibon

A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death.
K. Saijo….C.K. Glass. Cell 137:47–59, 2009.

April 17, 2009

Thomas Möller

Uniquely hominid features of adult human astrocytes.
N.A. Oberheim....M. Nedergaard. J Neurosci 29:3276-87, 2009.

April 3, 2009

Yi Hsing Lin

Phagocytosis and intracellular killing of MD-2 opsonized Gram-negative bacteria depend on TLR4 signaling.
V. Jain….A. Visintin. Blood 111:4637-45, 2008.

March 6, 2009

Nephi Stella

CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells.
E.D. Ponomarev....B.N. Dittel. J Neurosci 27:10714-21, 2007.

February 20, 2009

Gwenn Garden

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke.
A. Liesz….R. Veltkamp. Nature Med 15:192-99, 2009.

February 6, 2009

Eiron Cudaback

Altered P2X7-receptor level and function in mouse models of Huntington’s disease and therapeutic efficacy of antagonist administration.
M. Díaz-Hernández....J.J. Lucas. FASEB J, published online January 26, 2009.

January 23, 2009

Eric Horne

Microglial VEGF receptor response is an integral chemotactic component in Alzheimer’s disease pathology.
J.K. Ryu….J.G. McLarnon. J Neurosci 29:3-13, 2009.

January 9, 2009

Aurelio Silvestroni

Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer’s and other cns pathologies.
B.Ji….T. Suhara. J Neurosci 28:12255–12267, 2008.

October 31, 2008

Yi Hsing Lin

Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
T. Town….R. A. Flavell. Nature Med 14:681-687, 2008.

October 3, 2008

Richard Lee

Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1.
S. Jang….R.W. Johnson. PNAS 105:7534-7539, 2008.

September 19, 2008

Gwenn Garden

Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.
S.H. Choi….S.S. Sisodia. Neuron 59:568-80, 2008.

May 30, 2008

Will Marrs

Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation.
C.B. Johansson....H.M. Blau. Nature Cell Biol 10:575-583, 2008.

May 16, 2008

Faith Reyes

Cell-specific actions of HIV-Tat and morphine on opioid receptor expression in glia.
J. Turchan-Cholewo....A.J. Bruce-Keller. J Neurosci Res March 13, 2008 (Epub ahead of print).

April 18, 2008

Suman Jayadev

A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS.
S. Lehnardt....J.R. Weber. J Neurosci 28:2320-2331, 2008.

April 4, 2008

Elsa Raibon

Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis.
M.A. Sanjuan….D.R. Green. Nature 450:1253-1257, 2007.

March 7, 2008

Thomas Möller

Resting microglial motility is independent of synaptic plasticity in mammalian brain.
L.J. Wu & M. Zhuo. J Neurophysiol (in press).

February 8, 2008

Nephi Stella

Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington’s disease.
D.A. Simmons....G. Lynch. Glia 55:1074-1084, 2007.

January 25, 2008

Eiron Cudaback

Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia.
M.A. Retamal....C. Giaume. J Neurosci 27:13781-13792, 2007.

January 11, 2008

Gwenn Garden

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions.
A. Mildner....M. Prinz. Nature Neurosci 10:1544-53, 2007.

December 14, 2007

Guest Speaker

Ron Strohmeyer from Northwest Nazarene University.

December 12, 2007

Guest Speaker

Dr. Mami Noda, Kyushu University, Japan.

Bradykinin-induced microglial migration mediated by B1-Bradykinin receptors depends on Ca2+ influx via reverse-mode activity of the Na+/Ca2+ exchanger.
M.I….M. Noda. J Neurosci 27:13065–13073, 2007.

November 30, 2007

Richard Lee

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life.
B. Ajami....F.M.V. Rossi. Nature Neurosci 10:1538-1543, 2007.

October 19, 2007

Aurelio Silvestroni

Notch signaling modulates the activation of microglial cells.
L. Grandbarbe….P. Heuschling. Glia 55:1519-1530, 2007.

August 24, 2007

Aaron Miller

Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity.
R.S. Griffin….Chi Him. J Neurosci 27:8699–8708, 2007.

August 10, 2007

Faith Reyes

Elevated neuronal expression of CD200 protects wlds mice from inflammation-mediated neurodegeneration.
T. Chitnis….S.J. Khoury. Am J Pathology 170:1695-1712, 2007.

CD200 ligand–receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4.
A. Lyons....M.A. Lynch. J Neurosci 27:8309–8313, 2007.

July 10, 2007

Elsa Raibon

Combined minocycline plus pyruvate treatment enhances effects of each agent to inhibit inflammation, oxidative damage, and neuronal loss in an excitotoxic animal model of Huntington’s disease.
J.K. Ryu….J.G. McLarnon. Neuroscience 141:1835-1848, 2006.

June 26, 2007

Nephi Stella

Neuroinflammation alters the hippocampal pattern of behaviorally induced arc expression.
S. Rosi….G.L. Wenk. J Neurosci 25:723-731, 2005.

Minireview Arc/Arg3.1: Linking gene expression to synaptic plasticity and memory.
A.V. Tzingounis & R.A. Nicoll. Neuron 52:403-407, 2006.

June 12, 2007

Gwenn Garden

TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis.
K. Takahashi....H. Neumann. PLoS Med 4:0675-0689, 2007.

May 29, 2007

Eiron Cudaback

Purines induce directed migration and rapid homing of microglia to injured pyramidal neurons in developing hippocampus.
D. Kurpius....M.E. Dailey. Glia 55:873–884, 2007.

May 15, 2007

Thomas Möller

Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain.
H.B. Choi….J.G. McLarnon. J Neurosci 27:4957-4968, 2007.

May 1, 2007

Sarah Swarts

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis.
S. Koizumi….K. Inoue. Nature, published online April 4, 2007.

April 17, 2007

Jonathan Weinstein

Neurobiology of disease selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain.
M. Lalancette-Hebert….J. Kriz. Nat Med, March 11, 2007 (Epub ahead of print).

April 3, 2007

Aaron Miller

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.
J.E. Khoury....A.D. Luster. J Neurosci 27:2596-2605, 2007.

March 20, 2007

Faith Reyes

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model.
Y. Yoshiyama....V. M.-Y. Lee. Neuron 53:337–351, 2007.

March 6, 2007

Elsa Raibon

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis.
D.R. Beers….S.H. Appel. PNAS 103(43):16021-16026, 2006.

February 6, 2007

Nephi Stella

Evidence for synaptic stripping by cortical microglia.
B.D. Trapp….R. Ransohoff. Glia 55:360–368, 2007.

January 23, 2007

Gwenn Garden

Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-phox-mediated generation of reactive oxygen species.
Y. Liu….K. Fassbender. J Neurosci 26(50):12904-12913, 2006.

January 9, 2006

Suman Jayadev

Notch-1 up-regulation and signaling following macrophage activation modulates gene expression patterns known to affect antigen-presenting capacity and cytotoxic activity.
E. Monsalve….M.J. Diaz-Guerra. J Immunol 5362-5373, 2006.

December 12, 2006

Eiron Cudaback

The P2Y12 receptor regulates microglial activation by extracellular nucleotides.
S.E. Haynes....D. Julius. Nature Neurosci 9:1512-19, 2006.

November 14, 2006

Thomas Möller

The chemokine system in diverse forms of macrophage activation and polarization.
A. Mantovani....M. Locati. TRENDS Immunol 25:677-86, 2004.

Alternative activation of macrophages.
S. Gordon. Nat Rev Immunol 3:23-35, 2003.

October 3, 2006

Carrie Bishop

The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signaling.
M. Carty….A.G. Bowie. Nature Immun 7:1074-1081, 2006.

September 19, 2006

Jonathan Weinstein

Sensitization to brain antigens after stroke is augmented by lipopolysaccharide.
K.J. Becker….Z.C. Ye. J Cereb Blood Flow Metab 25:1634-1644, 2005.

September 5, 2006

Aaron Miller

A role for P2X7 in microglial proliferation.
F. Bianco….C. Verderio. J Neurochem, July 6, 2006 (Epub ahead of print).

August 22, 2006

Faith Reyes

Control of microglial neurotoxicity by the fractalkine receptor.
A.E. Cardona….R.M. Ransohoff. Nature Neurosci 9:917-924, 2006.

July 25, 2006

Elsa Raibon

Does gender matter?
B.A. Barres. Nature 442:133–136, 2006.

June 27, 2006

Mary Nivison

Neurogenic niche modulation by activated microglia: transforming growth factor ß increases neurogenesis in the adult dentate gyrus.
D. Battista….F.J.Pitossi. Eur J Neurosci 23:83–93, 2006.

June 13, 2006

Nephi Stella

Onset and progression in inherited ALS determined by motor neurons and microglia.
S. Boillée….D.W. Cleveland. Science 312:1389-1392, 2006.

May 31, 2006

Giulio Muccioli

Reactive microgliosis participates in MPP+-induced dopaminergic neurodegeneration: role of 67 kDa laminin receptor.
T. Wang….J.S. Hong. FASEB J 20:906-915, 2006.

May 16, 2006

Gwenn Garden

Inhibition of an equilibrative nucleoside transporter by cannabidiol: A mechanism of cannabinoid immunosuppression.
E.J. Carrier….C.J. Hillard. PNAS 103:7895-7900, 2006.

May 2, 2006

Suman Jayadev

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer’s disease.
A.R. Simard….S. Rivest. Neuron 49:489-502, 2006.

April 18, 2006

Eiron Cudaback

BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain.
J. Coull….Y. De Koninck. Nature 438:1017-1021, 2005.

April 4, 2006

Aaron Miller

Astrocytes induce hemeoxygenase-1 expression in microglia: a feasible mechanism for preventing excessive brain inflammation.
K. Min…E. Joe. J Neurosci 26:1880-1887, 2006.

March 7, 2006

Faith Reyes

Microglia activated by IL-4 or IFN-g differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells.
O. Butovsky….M. Schwartz. Mol Cell Neurosci 31:149–160, 2006.

February 21, 2006

Soyon Hong

CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS.
E.A. Eugenin….J.W. Berman. J Neurosci 26(4):1098-106, 2006.

February 7, 2006

Thomas Möller

Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood.
Y. Ziv….M. Schwartz. Nature Neurosci 9:268-275, 2006.

January 24, 2006

Elsa Raibon

Visualization of MG in living tissues using Iba-1EGFP transgenic mice
T. Hirasawa….S. Kohsaka. J Neurosci Res 81:357–362, 2005.

Macrophage/microglia-specific protein Iba1 enhances membrane ruffling and rac activation via phospholipase C-gamma-dependent pathway.
H. Kanazawa….Y. Imai. J Biol Chem 277:20026–20032, 2002.

January 10, 2006

Jonathan Weinstein

Amyloid beta peptide 1–40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures.
M. Lotz….R. Nau. J Neurochemistry 94:289–298, 2005.

December 13, 2005


Review of the Society for Neuroscience Meeting.

November 29, 2005

Nephi Stella

Infiltrative microgliosis: activation and long-distance migration of subependymal microglia following periventricular insults.
W.S. Carbonell….J.W. Mandell. J Neuroinflammation 2:1-9, 2003.

Migration of perilesional microglia after focal brain injury and modulation by CC chemokine receptor 5: An in situ time-lapse confocal imaging study.
W.S. Carbonell….J.W. Mandell. J Neurosci 25:7040-7047, 2005.

October 4, 2005

Tom Montine


September 6, 2005

Fabio Bianco

ATP released from astrocytes induces IL1 beta release from microglia through shedding of vesicles.

August 23, 2005

Anke Witting

Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice.
D. Huang….R. Ransohoff. FASEB J 19:761-772, 2005.

August 9, 2005

Gwenn Garden

Activation of microglia by aggregated ß-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-γ and IL-4 render them protective.
O. Butovsky….M. Schwartz. Mol Cell Neurosci 29:381-393, 2005.

June 28, 2005

Eiron Cudaback

Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity.
L. Vallieres & P.E. Sawchenko. J Neurosci 23: 5197–5207, 2003.

Characterization of microglia induced from mouse embryonic stem cells and their migration into the brain parenchyma.
T. Tsuchiya….K Shimizu. J Neuroimmunol 160:210–218, 2005.

June 14, 2005

Soyon Hong

ATP mediates rapid microglial response to local brain injury in vivo.
D. Davalos….W.B. Gan. Nat Neurosci, May 15, 2005 [Epub ahead of print].

May 17, 2005

Jonathan Weinstein

Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia.
Y.S. Kim….T.H. Joh. J Neurosci 25:3701-3711, 2005.

May 3, 2005

Thomas Möller

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.
A. Nimmerjahn….F. Helmchen. Science, April 14, 2005 (Epub ahead of print).

April 19, 2005

Nephi Stella

Primordial hematopoietic stem cells generate microglia but not myelin-forming cells in a neural environment.
S. Vitry….M. Dubois-Dalcq. J Neurosci 23:10724-10731, 2003.

Intracerebroventricular injection of microglia protects against focal brain ischemia.
Y. Kitamura….T. Taniguchi. J Pharmacol Sci 94:203-206, 2004.

April 5, 2005

Barry Rickman

Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor Cß-induced neurotoxicity in concert with microglial-derived fas ligand.
D.L. Taylor….J.M. Pocock. J Neurosci 25:2952-2964, 2005.

March 22, 2005

Patrick Weydt

Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.
M. Greter….B. Becher. Nat Med 11:328-334, 2005.

March 8, 2005

Anke Witting

Experimental autoimmune encephalomyelitis repressed by microglial paralysis.
F.L. Heppner….A. Aguzzi. Nat Med 11:146-52, 2005.

February 8, 2005

Gwenn Garden

Neuroinflammation alters the hippocampal pattern of behaviorally induced Arc expression.
S. Rosi….G. Wenk. J Neurosci 25:723-731, 2005.

January 25, 2005

Ingunn Stromnes

Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.
M.J. Craner….S.G. Waxman. Glia 49:220-229, 2005.

January 11, 2005

Eiron Cudaback

Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse.
A. Roumier….A. Bessis. J Neurosci 24:11421-28, 2004.

December 14, 2004

Jonathan Weinstein

Endotoxin preconditioning prevents cellular imflammatory response during ischemic neuroprotection in mice.
H. Rosenzweig….M. Stenzel-Poore. Stroke 35:2576-81, 2004.

November 30, 2004


Review of the Society for Neuroscience Meeting.

October 14, 2004

Soyon Hong

Microglia initiate central nervous sytem innate and adaptive immune responses through multiple TLRs.
J.K. Olson & S.D. Miller. J Immunol 173:3916-24, 2004.

August 24, 2004

Anke Witting

Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson’s disease.
E.J. Benner….H.E. Gendelman. PNAS 101:9435–9440, 2004.

August 10, 2004

Nephi Stella

Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.
D.M. Wilcock….D. Morgan. J Neurosci 24:6144–6151, 2004.

July 27, 2004

Barry Rickman

Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization.
M.K. Chen….T.R. Guilarte. Brain 127:1379-1392, 2004.

July 13, 2004

Patrick Weydt

Sodium butyrate suppresses interferon-gamma-, but not lipopolysaccharide-mediated induction of nitric oxide and tumor necrosis factor-alpha in microglia.
Hee-Sun Kima….Inn-Oc Han. J Neuroimmunol 151:85–93, 2004.

Regulation of microglial inflammatory response by sodium butyrate and short-chain fatty acids.
J. Huuskonen….A. Salminen. Br J Pharmacol 141:874–880, 2004.

June 29, 2004

Gwenn Garden

Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease.
T. Furuya….H. Mochizuki. J Neurosci 24(8):1865–1872, 2004.

June 15, 2004

Ingunn Stromnes

Current Research

May 18, 2004

Eiron Cudaback

Microglia are activated to become competent antigen presenting and effector cells in the inflammatory environment of the Theiler’s virus model of multiple sclerosis.
C.L. Mack….S.D. Miller. J Neuroimmunol 144:68–79, 2003.

May 4, 2004

Jonathan Weinstein

Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia.
J. Li….M. Kamoun. J Neurol Sci 215:95-103, 2003.

April 20, 2004

Soyon Hong

Microglia expressing interleukin-13 undergo cell death and contribute to neuronal survival in vivo.
W.H. Shin….B.K. Jin. Glia 46:142-152, 2004.

April 6, 2004

Thomas Möller

Diverse microglial motility behaviors during clearance of dead cells in hippocampal slices.
M.A. Petersen & M.E. Dailey. Glia 46:195–196, 2004.

February 24, 2004

Anke Witting

Neuronal apoptotic bodies: phagocytosis and degradation by primary microglial cells.
A. Stolzing….T. Grune. FASEB, February 6, 2004 (Epub ahead of print).

February 10, 2004

Barry Rickman

Neurons and astrocytes respond to prion infection by inducing microglia recruitment.
M. Marella & J. Chabry. J Neurosci 24:620-27, 2004.

January 27, 2004

Lisa Walter

Constitutive expression of a costimulatory ligand on antigen-presenting cells in the nervous system drives demyelinating disease.
S.P. Zehntner....S. Fournier. FASEB 17:1910-1912, 2003.

January 13, 2004

Patrick Weydt

Inflammatory blockade restores adult hippocampal neurogenesis.
M. Monje....T.D. Palmer. Science 302:1760-65, 2003.

December 16, 2003

Gwenn Garden

Microglia, a potential source of neurons, astrocytes, and oligodendrocytes.
A. Yokoyama....J. Tanaka. Glia 45:96-104, 2004.

December 2, 2003

Eiron Cudaback

Inflammation is detrimental for neurogenesis in adult brain.
C.T. Ekdahl....O. Lindvall. PNAS 100:13632-13637, 2003.

November 4, 2003

Thomas Möller

Regional effects of wheel running and environmental enrichment on cell genesis and microglia proliferation in the adult murine neocortex.
D. Ehninger & G. Kempermann. Cerebral Cortex 13:845-851, 2003.

Increased morphological diversity of microglia in the activated hypothalamic supraoptic nucleus.
A.E. Ayoub & A.K. Salm. J Neurosci 23:7759-7766, 2003.

October 21, 2003

Jonathan R. Weinstein

Reduced cerebral injury in CRH-R1 deficient mice after focal ischemia: A potential link to microglia and atrocytes that express CRH-R1.
S.L. Stevens....M.P. Stenzel-Poore. J Cereb Blood Flow Metab 23:1151-1159, 2003.

October 7, 2003

Nephi Stella

Estrogen receptor-alpha mediates the brain anti-inflammatory activity of estradiol.
E. Vegeto....A. Maggi. PNAS 100(16):9614-9619, 2003.

September 9, 2003


Summarize the Euroglia and Neuro-Viroloy Meetings.

August 12, 2003

Anke Witting

Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.
K. Lauber....S. Wesselborg. Cell 113:717-730, 2003.

July 29, 2003

Barry Rickman

Activation of innate immunity in the CNS triggers neurodegeneration through a toll-like receptor 4-dependent pathway.
S. Lehnard....T. Vartanian. PNAS 100:8514-8519, 2003.

July 15, 2003

Lisa Walter

Colocalization of ATP release sites and ecto-ATPase activity at the extracellular surface of human astrocytes.
S.M. Joseph....G.R. Dubyak. J Biol Chem 278:23331-23342, 2003.

July 1, 2003

Patrick Weydt

Aging and glial responses to lipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity.
Z. Xie....C.E. Finch. Exp Neurol 182:135-141, 2003.

June 17, 2003

Gwenn Garden

CD36 mediates the innate host response to {beta}-amyloid.
J.B. El Khoury....A.D. Luster. J Exp Med, 2003 (Epub ahead of print).

June 3, 2003

Jonathan Weinstein

Cell type-specific roles for tissue plasminogen activator released by neurons or microglia after excitotoxic injury.
C.J. Siao....S.E. Tsirka. J Neurosci 23(8):3234 -3242, 2003.

May 20, 2003

Eiron Cudaback

P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's Disease.
L.K. Parvathenani....R. Posmantur . J Biol Chem 278:13309-13317, 2003.

April 22, 2003

Nephi Stella

The extracellular matrix and cytokines regulate microglial integrin expression and activation.
R. Milner & I.L. Campbell. J Immunol 170:3850-3858, 2003.

April 8, 2003

Thomas Möller

Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity.
D.L. Taylor....J.M. Pocock. J Neurosci 23(6):2150 -2160, 2003.

March 25, 2003

Stephanie Balcaitis

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain.
D.J. Cua....J.D. Sedgwick. Nature 421:744-748, 2003.

March 11, 2003

Anke Witting

Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system.
S.S. Yan....H. Jiang. Nat Med 9:287-293, 2003.

February 25, 2003

Lisa Walter

Microglia cyclooxygenase-2 activity in experimental gliomas: possible role in cerebral edema formation.
B. Badie....J. Vorpahl. Clin Cancer Res 9:872-877, 2003

February 10, 2003

Patrick Weydt

Impairment of protein homeostasis and decline of proteasome activity in microglial cells from adult Wistar rats.
A. Stolzing & T. Grune. J Neurosci Res 71:264-71, 2003.

January 24, 2003

Nephi Stella

Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis.
Cathryn Broderick....Andrew D. Dick. Am J Pathology 161:1669-1677, 2002.

Down-regulation of the macrophage lineage through interaction with OX2 (CD200).
R.M. Hoek....D. Sedgwick. Science 290:1768-1771, 2000.

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