UW Department of Surgery

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Introduction from the Chairman:
Quality of Life Depends on Basic Research
Carlos A. Pellegrini, M.D.

2007 Honors and Awards

CARDIOTHORACIC:

Gabriel S. Aldea, M.D.
minimizing morbidity of cardiopulmonary bypass

Michael S. Mulligan, M.D.
cytokines and chemokines in direct ischemia reperfusion injury of lung and cardiothoracic transplant rejection

Edward D. Verrier, M.D.
cellular and molecular mechanisms of myocardial ischemia-reperfusion injury

HMC / TRAUMA SURGERY

Saman Arbabi, M.D., M.P.H.
Inflammatory Signaling Response to Thermal Injury Beta-Blocker Therapy in the Injured Patient

Eileen Bulger, M.D.
- hypertonic resuscitation for blunt trauma.
- prehospital airway management & treatment for traumatic brain injury.
- national variability in prehospital care following injury.
- immunomodulation of the alveolar macrophage.
- management of necrotizing soft tissue infections
- rib fracture management.
- Crash Injury Research and Engineering Network (CIREN)

Joseph Cuschieri, M.D.
- toll-mediated signaling.
- trauma Induced mononuclear cell reprogramming.
- proposed mechanism of lipid raft clustering and reprogramming.
- Trauma Induced Phenotypic Alterations
- Class Prediction Based on Cytokine Profiles

Nicole Gibran, M.D.
- burn wound repair.
- cytokine response to thermal injury.
- neuroinflammatory response to wound repair.

Gregory J. Jurkovich, M.D.
- national study on costs and effectiveness of trauma care.
- Washington State trauma registry and central region CQI.
- post-traumatic stress disorder in trauma patients.
Field Triage Document and Implementation Toolkit.

Ronald V. Maier, M.D.
- Harborview Injury Prevention and Research Center.
- clinical trials in the surgical intensive care unit.
- modulation of the excessive inflammatory response to
biomaterials.
- modulation of the trauma-related macrophage
inflammatory response to prevent ARDS, MOFS and death.
- genomic controlled phenotypic response to severe injury.

Grant O’Keefe, M.D., MPH
- pathophysiology of post-injury infection and organ failure

PEDIATRIC SURGERY

Stephen S. Kim, M.D.
- tissue engineering and regenerative medicine.

Robert S. Sawin, M.D.
neuroblastoma in the pediatric patient.

John Waldhausen, M.D.
surgical treatment review improves children’s healing process.

PLASTIC AND RECONSTRUCTIVE SURGERY

Loren H. Engrav, M.D.
- laboratory research.
- NIDRR burn model system research.
- NIDRR field initiated project.

Anne Hocking, Ph.D.
- wound healing.

Richard A. Hopper, M.D., M.S.
- cleft lip and palate.
- syndromic severe midface hypoplasia.
- craniosynostosis.

Matthew B. Klein, M.D.
- Organization and Delivery of Burn Care.
- Psychosocial and Functional Outcomes of Older Adults Following Burn Injury.
- The Impact of Resuscitation Fluid Volume Received on Outcome.
- Development of Validated Patient Reported Outcome Measurement Tools for Burn Survivors.

TRANSPLANT SERVICES

Wei Li, M.D., Ph.D.
- mechanism of organ transplant tolerance rejection: the role of regulatory T cells (Treg), dendritic cells (DC), and costimulatory molecules on tolerance induction.

James D. Perkins, M.D.
- Achieving Transplantation Goals through Basic Science Investigations, Clinical Outcomes Research, and Quality Studies

UWMC / GENERAL SURGERY

Benjamin O. Anderson, M.D.
- the breast health global initiative.

David R. Flum, M.D., MPH
- advancing the clinical science of surgery using outcomes research tools.

Karen D. Horvath, M.D.
- surgical outcomes research: clinical trials.
- surgical education.

Brant K. Oelschlager, M.D., Carlos A. Pellegrini, M.D., Roger Tatum, M.D.
- The Swallowing Center at the University of Washington.

Richard Satava, M.D.
- objective assessment of surgical skills.
- operating room of the future.

Mika Sinanan, M.D., Ph.D.
- Biorobotics Laboratory Collaboration
- ISIS: Institute for Surgical and Interventional Simulation

Raymond S. Yeung, M.D.
- The role of the TSC1/2 complex in tumor development

VAPSHCS / GENERAL SURGERY

Lorrie Langdale, M.D.
- Hepatic Ischemia-Reperfusion: Evolution of an Injury
- JAK/STAT and SOCS in Inflammation
- SOCS Proteins, Cytokine Control and the Response to Hepatic IR Injury

Michael Sobel, M.D.
Heparin, platelets, and vascular cells

VASCULAR SURGERY

Kirk W. Beach, Ph.D., M.D.
- Tissue Pulsatility Imaging of Brain
- Atherosclerotic Plaque Neovascularization
- Ultrasound Reading Center for Carotid Stenosis

Alexander W. Clowes, M.D.
- Regulation of vascular smooth muscle cell growth.

Günter Daum, Ph.D.
- A role for sphingosine-1-phosphate receptor-2 in smooth muscle cell differentiation and restenosis.

Thomas Hatsukami, M.D.
Magnetic resonance imaging of the high-risk atherosclerotic plaque.

Ted R. Kohler, M.D., M.Sc.
- Healing of Prosthetic Vascular Grafts
- Preventing Dialysis Access Failure
- Factors Involved in Restenosis
- Endovascular Repair of Abdominal Aortic Aneurysms

Department of Surgery Annual Research Report Managing Editor and contact: Eileen Herman