UW Department of Surgery

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Introduction from the Chairman:
Clinical Treatment Begins in the Research Laboratory
Carlos A. Pellegrini, M.D.

2005 Honors and Awards

CARDIOTHORACIC:

Gabriel S. Aldea, M.D.
minimizing morbidity of cardiopulmonary bypass

Riyad Karmy-Jones, M.D.
- indications and outcome following thoracotomy.
- traumatic aortic rupture.
- lung inflammation.

Michael S. Mulligan, M.D.
cytokines and chemokines in direct ischemia reperfusion injury of lung and cardiothoracic transplant rejection

Edward D. Verrier, M.D.
cellular and molecular mechanisms of ischemia-reperfusion injury

HMC / TRAUMA SURGERY

Eileen Bulger, M.D.
- hypertonic resuscitation for blunt trauma.
- prehospital airway management & treatment for
traumatic brain injury.
- immunomodulation of the alveolar macrophage.
- the cytokine profile of burn patients receiving plasmapheresis.
- rib fracture management.
- variations in the care of head injured patients.
- the use of anabolic steroids in the chronically ventilated
surgical patient.

Joseph Cuschieri, M.D.
- toll-mediated signaling.
- priming of mononuclear cells.
- immunomodulation of mononuclear cells.

Nicole Gibran, M.D.
- burn wound repair.
- cytokine response to thermal injury.
- neuroinflammatory response to wound repair.

Gregory J. Jurkovich, M.D.
- national study on costs and effectiveness of trauma care.
- washington state trauma registry and central region cqi.
- post-traumatic stress disorder in trauma patients.

Ronald V. Maier, M.D.
- harborview injury prevention and research center.
- clinical trials in the surgical intensive care unit.
- modulation of the excessive inflammatory response to
biomaterials.
- elucidation and modulation of the trauma-related macrophage
inflammatory response to prevent ards, mofs and death in
the severely injured and septic patient.

Charles Mock, M.D., Ph.D.
strengthening trauma systems in developing countries.
- the essential trauma care project.
- capacity building for injury control.
- crash injury research and engineering network (ciren).

Avery B. Nathens, M.D., Ph.D., MPH
effect of organized systems of trauma care on motor-vehicle
crash mortality.
- relationship between trauma center volume and outcomes.
- a resource-based assessment of trauma care in the united states.
- the effect of interfacility transfer on outcome in an urban
trauma system.
- randomized, prospective trial of antioxidant supplementation in
critically ill surgical patients.

Grant O’Keefe, M.D., MPH
pathophysiology of post-injury infection and organ failure

Robert K. Winn, Ph.D.
ischemia-reperfusion injury.
- sepsis (overwhelming infection).
- adult respiratory distress syndrome.

PEDIATRIC SURGERY

Robert S. Sawin, M.D.
neuroblastoma in the pediatric patient.

John Waldhausen, M.D.
surgical treatment review improves children’s healing process.

PLASTIC AND RECONSTRUCTIVE SURGERY

Loren H. Engrav, M.D.
hypertrophic scarring.
- uw burn injury rehabilitation model system.

Anne Hocking, Ph.D., Frank Isik, M.D.
wound healing.

Richard A. Hopper, M.D., M.S.
cleft lip and palate.
- syndromic severe midface hypoplasia.
- craniosynostosis.

TRANSPLANT SERVICES

Christian S. Kuhr, M.D.
identification of genes responsible for immunologic tolerance.
- immunologic tolerance in a large animal model.
- lymphocyte development and differentiation: the role of the notch gene.

Wei Li, M.D., Ph.D.
mechanism of organ transplant tolerance rejection: the role of regulatory t cells (treg), dendritic cells (dc), and costimulatory molecules on tolerance induction.

James D. Perkins, M.D.
a model to study the liver’s role in peripheral tolerance.

UWMC / GENERAL SURGERY

Benjamin O. Anderson, M.D.
the breast health global initiative

David R. Flum, M.D., MPH
advancing the clinical science of surgery using outcomes research tools

Karen D. Horvath, M.D.
surgical outcomes research: clinical trials.
- surgical education.

Brant K. Oelschlager, M.D., Carlos A. Pellegrini, M.D.
the swallowing center at the university of washington

Richard Satava, M.D.
objective assessment of surgical skills.
- operating room of the future.

Mika Sinanan, M.D., Ph.D.
ISIS: Institute for Surgical and Interventional Simulation

Raymond S. Yeung, M.D.
tumor development in tuberous sclerosis complex

VAPSHCS / GENERAL SURGERY

Lorrie Langdale, M.D.
Hepatic Ischemia-Reperfusion Injury: The Search for Control
- JAK/STAT Cell Signaling Pathway and Suppressors of Cytokine Signaling (SOCS Proteins)
- SOCS Proteins, Cytokine Control and the Response to Hepatic IR Injury

Michael Sobel, M.D.
heparin, platelets, and vascular cells

VASCULAR SURGERY

Kirk W. Beach, Ph.D., M.D.
- Tissue Pulsatility Imaging for the Evaluation of Tissue Perfusion
- Tissue Pulsatility Imaging of Muscle
- Intracranial Tissue Pulsatility Imaging (TPI)
- Arteriolar and Venular Plethysmograpic Imaging
- TPI and Doppler Waveforms
- Real-Time Vibrometry

Alexander W. Clowes, M.D.
Regulation of vascular smooth muscle cell growth

Günter Daum, Ph.D.
Modulation of growth factor signaling in vascular smooth muscle cells by inflammatory cytokines

Thomas Hatsukami, M.D.
Magnetic resonance imaging of the high-risk atherosclerotic plaque

Ted R. Kohler, M.D.
- endovascular therapy.
- effect of blood flow on intimal hyperplasia and access graft failure.
- dialysis access grafts.

Daniel F. Leotta, Ph.D.
- vein graft surveillance using 3d ultrasound imaging.
- measurement of abdominal aortic aneurysms with 3d ultrasound.
- muscle blood flow assessment with 3d ultrasound imaging.
- automated measurement of flow-mediated vessel dilation.

Department of Surgery Annual Research Report Managing Editor and contact: Eileen Herman