UW Department of Surgery

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Introduction from the Chairman:
discovering and distributing scientific knowledge
Carlos A. Pellegrini, M.D.

2006 Honors and Awards

CARDIOTHORACIC:

Gabriel S. Aldea, M.D.
minimizing morbidity of cardiopulmonary bypass

Michael S. Mulligan, M.D.
cytokines and chemokines in direct ischemia reperfusion injury of lung and cardiothoracic transplant rejection

Edward D. Verrier, M.D.
cellular and molecular mechanisms of myocardial ischemia-reperfusion injury

HMC / TRAUMA SURGERY

Eileen Bulger, M.D.
- hypertonic resuscitation for blunt trauma.
- prehospital airway management & treatment for traumatic brain injury.
- national variability in prehospital care following injury.
- immunomodulation of the alveolar macrophage.
- management of necrotizing soft tissue infections
- rib fracture management.

Joseph Cuschieri, M.D.
- toll-mediated signaling.
- trauma Induced mononuclear cell reprogramming.
- proposed mechanism of lipid raft clustering and reprogramming.

Nicole Gibran, M.D.
- burn wound repair.
- cytokine response to thermal injury.
- neuroinflammatory response to wound repair.

Gregory J. Jurkovich, M.D.
- national study on costs and effectiveness of trauma care.
- Washington State trauma registry and central region CQI.
- post-traumatic stress disorder in trauma patients.

Ronald V. Maier, M.D.
- Harborview Injury Prevention and Research Center.
- clinical trials in the surgical intensive care unit.
- modulation of the excessive inflammatory response to
biomaterials.
- modulation of the trauma-related macrophage
inflammatory response to prevent ARDS, MOFS and death.
- genomic controlled phenotypic response to severe injury.

Charles Mock, M.D., Ph.D.
- strengthening trauma systems in developing countries.
- the essential trauma care project.
- capacity building for injury control.
- crash injury research and engineering network (CIREN).

Grant O’Keefe, M.D., MPH
- pathophysiology of post-injury infection and organ failure

PEDIATRIC SURGERY

Stephen S. Kim, M.D.
- tissue engineering and regenerative medicine.

Robert S. Sawin, M.D.
neuroblastoma in the pediatric patient.

John Waldhausen, M.D.
surgical treatment review improves children’s healing process.

PLASTIC AND RECONSTRUCTIVE SURGERY

Loren H. Engrav, M.D.
- laboratory research.
- NIDRR burn model system research.
- NIDRR field initiated project.

Anne Hocking, Ph.D., Frank Isik, M.D.
- wound healing.

Richard A. Hopper, M.D., M.S.
- cleft lip and palate.
- syndromic severe midface hypoplasia.
- craniosynostosis.

TRANSPLANT SERVICES

Christian S. Kuhr, M.D.
- identification of genes responsible for immunologic tolerance.
- immunologic tolerance in a large animal model.
- lymphocyte development and differentiation: the role of the notch gene.

Wei Li, M.D., Ph.D.
- mechanism of organ transplant tolerance rejection: the role of regulatory T cells (Treg), dendritic cells (DC), and costimulatory molecules on tolerance induction.

James D. Perkins, M.D.
- a model to study the liver’s role in peripheral tolerance.

UWMC / GENERAL SURGERY

Benjamin O. Anderson, M.D.
- the breast health global initiative.

David R. Flum, M.D., MPH
- advancing the clinical science of surgery using outcomes research tools.

Karen D. Horvath, M.D.
- surgical outcomes research: clinical trials.
- surgical education.

Brant K. Oelschlager, M.D., Carlos A. Pellegrini, M.D., Roger Tatum, M.D.
- The Swallowing Center at the University of Washington.

Richard Satava, M.D.
- objective assessment of surgical skills.
- operating room of the future.

Mika Sinanan, M.D., Ph.D.
- ISIS: Institute for Surgical and Interventional Simulation

Raymond S. Yeung, M.D.
- tumor development in tuberous sclerosis complex

VAPSHCS / GENERAL SURGERY

Lorrie Langdale, M.D.
- hepatic ischemia-reperfusion injury: the search for control
- JAK/STAT cell signaling pathway and suppressors of cytokine signaling (SOCS proteins)
- SOCS proteins, cytokine control and the response to hepatic IR injury

Michael Sobel, M.D.
heparin, platelets, and vascular cells

VASCULAR SURGERY

Kirk W. Beach, Ph.D., M.D.
- tissue pulsatility imaging for the evaluation of tissue perfusion.
- tissue pulsatility imaging of muscle.
- intracranial tissue pulsatility imaging (TPI).
- arteriolar and venular plethysmograpic imaging.
- TPI and doppler waveforms.
- real-time vibrometry.
- video photoplethysmography.
- Ultrasound Reading Center for carotid stents.

Alexander W. Clowes, M.D.
- regulation of vascular smooth muscle cell growth.

Günter Daum, Ph.D.
Modulation of growth factor signaling in vascular smooth muscle cells by inflammatory cytokines.

Thomas Hatsukami, M.D.
Magnetic resonance imaging of the high-risk atherosclerotic plaque.

Ted R. Kohler, M.D.
- endovascular therapy.
- effect of blood flow on intimal hyperplasia and access graft failure.
- dialysis access grafts.

Daniel F. Leotta, Ph.D.
- vein graft surveillance using 3D ultrasound imaging.
- measurement of abdominal aortic aneurysms with 3D ultrasound.
- measurement of flow-mediated vessel dilation.

Department of Surgery Annual Research Report Managing Editor and contact: Eileen Herman