Selected Publications (Pubmed Search)

Duplicate abalone egg coat proteins bind sperm lysin similarly, but evolve oppositely, consistent with molecular mimicry at fertilization.

Aagaard JE, Springer SA, Soelberg SD, Swanson WJ.

PLoS Genet. 2013 Feb;9(2)

Reproduction and Immunity-Driven Natural Selection in the Human WFDC Locus.

Ferreira Z, Seixas S, Andrés AM, Kretzschmar WW, Mullikin JC, Cherukuri PF, Cruz P, Swanson WJ; NISC Comparative Sequencing Program, Clark AG, Green ED, Hurle B.

Mol Biol Evol. 2013 Jan 25

Positive selection within a diatom species acts on putative protein interactions and transcriptional regulation.

Koester JA, Swanson WJ, Armbrust EV.

Mol Biol Evol. 2013 Feb;30(2):422-34

Evolution of the egg: new findings and challenges.

Claw KG, Swanson WJ.

Annu Rev Genomics Hum Genet. 2012;13:109-25. Review.

The Tegula tango: a coevolutionary dance of interacting, positively selected sperm and egg proteins.

Hellberg ME, Dennis AB, Arbour-Reily P, Aagaard JE, Swanson WJ.

Evolution. 2012 Jun;66(6):1681-94.

Trans genomic capture and sequencing of primate exomes reveals new targets of positive selection.

George RD, McVicker G, Diederich R, Ng SB, MacKenzie AP, Swanson WJ, Shendure J, Thomas JH.

Genome Res. 2011 Oct;21(10):1686-94.

Selection in the rapid evolution of gamete recognition proteins in marine invertebrates.

Vacquier VD, Swanson WJ.

Cold Spring Harb Perspect Biol. 2011 Nov 1;3(11). Review

Identification of ejaculated proteins in the house mouse (Mus domesticus) via isotopic labeling.

Dean MD, Findlay GD, Hoopmann MR, Wu CC, MacCoss MJ, Swanson WJ, Nachman MW.

BMC Genomics. 2011 Jun 10;12:306

Beyond the phenotypic gambit: molecular behavioural ecology and the evolution of genetic architecture.

Springer SA, Crespi BJ, Swanson WJ

Mol Ecol. 2011 Apr 21

The Molecular Basis of Sex: Linking Yeast to Human.

Swanson WJ, Aagaard JE, Vacquier VD, Monné M, Al Hosseini HS, Jovine L

Mol Biol Evol. 2011 Jan 31

Functional diversification and evolution of antifreeze proteins in the antarctic fish Lycodichthys dearborni.

Kelley JL, Aagaard JE, MacCoss MJ, Swanson WJ

J Mol Evol. 2010 Aug;71(2):111-8

Detecting coevolution through allelic association between physically unlinked loci.

Rohlfs RV, Swanson WJ, Weir BS

Am J Hum Genet. 2010 May 14;86(5):674-85

Proteomics enhances evolutionary and functional analysis of reproductive proteins.

Findlay GD, Swanson WJ

Bioessays. 2010 Jan;32(1):26-36. Review

ZP domain proteins in the abalone egg coat include a paralog of VERL under positive selection that binds lysin and 18-kDa sperm proteins.

Aagaard JE, Vacquier VD, MacCoss MJ, Swanson WJ

Mol Biol Evol. 2010 Jan;27(1):193-203

Coevolution of interacting fertilization proteins.

Clark NL, Gasper J, Sekino M, Springer SA, Aquadro CF, Swanson WJ

PLoS Genet. 2009 Jul;5(7):e1000570

Bindin from a sea star.

Patiño S, Aagaard JE, MacCoss MJ, Swanson WJ, Hart MW

Evol Dev. 2009 Jul-Aug;11(4):376-81

Proteomics and comparative genomic investigations reveal heterogeneity in evolutionary rate of male reproductive proteins in mice (Mus domesticus).

Dean MD, Clark NL, Findlay GD, Karn RC, Yi X, Swanson WJ, MacCoss MJ, Nachman MW

Mol Biol Evol. 2009 Aug;26(8):1733-43

Proteomic discovery of previously unannotated, rapidly evolving seminal fluid genes in Drosophila.

Findlay GD, MacCoss MJ, Swanson WJ

Genome Res. 2009 May;19(5):886-96.

Targeted resequencing of two genes, RAGE and POLL, confirms findings from a genome-wide scan for adaptive evolution and provides evidence for positive selection in additional populations.

Kelley JL, Turkheimer K, Haney M, Swanson WJ

Hum Mol Genet. 2009 Feb 15;18(4):779-84

Adaptive evolution in rodent seminal vesicle secretion proteins.

Karn RC, Clark NL, Nguyen ED, Swanson WJ

Mol Biol Evol. 2008 Nov;25(11):2301-10

Adaptive Evolution in Rodent Seminal Vesicle Secretion Proteins.
Karn RC, Clark NL, Nguyen ED, Swanson WJ
Mol Biol Evol. 2008 Aug 20;

Proteomics reveals novel Drosophila seminal fluid proteins transferred at mating.
Findlay GD, Yi X, Maccoss MJ, Swanson WJ
PLoS Biol. 2008 Jul 29; 6(7): e178

Dietary change and adaptive evolution of enamelin in humans and among primates.
Kelley JL, Swanson WJ
Genetics. 2008 Mar ; 178(3): 1595-603

Extraordinary intraspecific diversity in oyster sperm bindin.
Moy GW, Springer SA, Adams SL, Swanson WJ, Vacquier VD
Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6): 1993-8

Positive selection in the human genome: from genome scans to biological significance.
Kelley JL, Swanson WJ
Annu Rev Genomics Hum Genet. 2008; 9: 143-60

Oyster sperm bindin is a combinatorial fucose lectin with remarkable intra-species diversity.
Springer SA, Moy GW, Friend DS, Swanson WJ, Vacquier VD
Int J Dev Biol. 2008; 52(5-6): 759-68

Adaptive evolution in an avian reproductive protein: ZP3.
Calkins JD, El-Hinn D, Swanson WJ
J Mol Evol. 2007 Nov ; 65(5): 555-63

Duplication and selection on abalone sperm lysin in an allopatric population.
Clark NL, Findlay GD, Yi X, MacCoss MJ, Swanson WJ
Mol Biol Evol. 2007 Sep ; 24(9): 2081-90

Gene duplication and adaptive evolution of digestive proteases in Drosophila arizonae female reproductive tracts.
Kelleher ES, Swanson WJ, Markow TA
PLoS Genet. 2007 Aug ; 3(8): e148

Evidence of amino acid diversity-enhancing selection within humans and among primates at the candidate sperm-receptor gene PKDREJ.
Hamm D, Mautz BS, Wolfner MF, Aquadro CF, Swanson WJ
Am J Hum Genet. 2007 Jul ; 81(1): 44-52

Rapidly evolving zona pellucida domain proteins are a major component of the vitelline envelope of abalone eggs.
Aagaard JE, Yi X, MacCoss MJ, Swanson WJ
Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46): 17302-7

Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution.
Gasper J, Swanson WJ
Am J Hum Genet. 2006 Nov ; 79(5): 820-30

Identification and comparative analysis of accessory gland proteins in Orthoptera.
Braswell WE, Andrés JA, Maroja LS, Harrison RG, Howard DJ, Swanson WJ
Genome. 2006 Sep ; 49(9): 1069-80

Molecular evolution and population genetic analysis of candidate female reproductive genes in Drosophila.
Panhuis TM, Swanson WJ
Genetics. 2006 Aug ; 173(4): 2039-47

Molecular evolution of seminal proteins in field crickets.
Andrés JA, Maroja LS, Bogdanowicz SM, Swanson WJ, Harrison RG
Mol Biol Evol. 2006 Aug ; 23(8): 1574-84

TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations.
Akey JM, Swanson WJ, Madeoy J, Eberle M, Shriver MD
Hum Mol Genet. 2006 Jul 1; 15(13): 2106-13

Rapid evolution of reproductive proteins in abalone and Drosophila.
Panhuis TM, Clark NL, Swanson WJ
Philos Trans R Soc Lond B Biol Sci. 2006 Feb 28; 361(1466): 261-8

Evolution of reproductive proteins from animals and plants.
Clark NL, Aagaard JE, Swanson WJ
Reproduction. 2006 Jan ; 131(1): 11-22

Pervasive adaptive evolution in primate seminal proteins.
Clark NL, Swanson WJ
PLoS Genet. 2005 Sep ; 1(3): e35

Speciation in birds: genes, geography, and sexual selection.
Edwards SV, Kingan SB, Calkins JD, Balakrishnan CN, Jennings WB, Swanson WJ, Sorenson MD
Proc Natl Acad Sci U S A. 2005 May 3; 102 Suppl 1: 6550-7

Adaptive evolution in the SRZ chemoreceptor families of Caenorhabditis elegans and Caenorhabditis briggsae.
Thomas JH, Kelley JL, Robertson HM, Ly K, Swanson WJ
Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12): 4476-81

Positive selection in the carbohydrate recognition domains of sea urchin sperm receptor for egg jelly(suREJ) proteins.
Mah SA, Swanson WJ, Vacquier VD
Mol Biol Evol. 2005 Mar ; 22(3): 533-41

Evolutionary expressed sequence tag analysis of Drosophila female reproductive tracts identifies genes subjected to positive selection.
Swanson WJ, Wong A, Wolfner MF, Aquadro CF
Genetics. 2004 Nov ; 168(3): 1457-65

A perforin-like protein from a marine mollusk.
Mah SA, Moy GW, Swanson WJ, Vacquier VD
Biochem Biophys Res Commun. 2004 Apr 2; 316(2): 468-75

Adaptive evolution of genes and gene families.
Swanson WJ
Curr Opin Genet Dev. 2003 Dec ; 13(6): 617-22

Population genetics of accessory gland proteins and sexual behavior in Drosophila melanogaster populations from Evolution Canyon.
Panhuis TM, Swanson WJ, Nunney L
Evolution. 2003 Dec ; 57(12): 2785-91

Sex peptide and the sperm effect in Drosophila melanogaster.
Swanson WJ
Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17): 9643-4

Positive selection in the egg receptor for abalone sperm lysin.
Galindo BE, Vacquier VD, Swanson WJ
Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8): 4639-43

Pervasive adaptive evolution in mammalian fertilization proteins.
Swanson WJ, Nielsen R, Yang Q
Mol Biol Evol. 2003 Jan ; 20(1): 18-20

A test for faster X evolution in Drosophila.
Betancourt AJ, Presgraves DC, Swanson WJ
Mol Biol Evol. 2002 Oct ; 19(10): 1816-9

Full-length sequence of VERL, the egg vitelline envelope receptor for abalone sperm lysin.
Galindo BE, Moy GW, Swanson WJ, Vacquier VD
Gene. 2002 Apr 17; 288(1-2): 111-7

Positive darwinian selection promotes heterogeneity among members of the antifreeze protein multigene family.
Swanson WJ, Aquadro CF
J Mol Evol. 2002 Mar ; 54(3): 403-10

The rapid evolution of reproductive proteins.
Swanson WJ, Vacquier VD
Nat Rev Genet. 2002 Feb ; 3(2): 137-44

Codon-substitution models to detect adaptive evolution that account for heterogeneous selective pressures among site classes.
Yang Z, Swanson WJ
Mol Biol Evol. 2002 Jan ; 19(1): 49-57

Evolutionary EST analysis identifies rapidly evolving male reproductive proteins in Drosophila.
Swanson WJ, Clark AG, Waldrip-Dail HM, Wolfner MF, Aquadro CF
Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13): 7375-9

Polymorphism in abalone fertilization proteins is consistent with the neutral evolution of the egg's receptor for lysin (VERL) and positive darwinian selection of sperm lysin.
Swanson WJ, Aquadro CF, Vacquier VD
Mol Biol Evol. 2001 Mar ; 18(3): 376-83

Positive Darwinian selection drives the evolution of several female reproductive proteins in mammals.
Swanson WJ, Yang Z, Wolfner MF, Aquadro CF
Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5): 2509-14

Maximum-likelihood analysis of molecular adaptation in abalone sperm lysin reveals variable selective pressures among lineages and sites.
Yang Z, Swanson WJ, Vacquier VD
Mol Biol Evol. 2000 Oct ; 17(10): 1446-55

A rapidly diverging EGF protein regulates species-specific signal transduction in early sea urchin development.
Kamei N, Swanson WJ, Glabe CG
Dev Biol. 2000 Sep 15; 225(2): 267-76

Concerted evolution in an egg receptor for a rapidly evolving abalone sperm protein.
Swanson WJ, Vacquier VD
Science. 1998 Jul 31; 281(5377): 710-2

Direct sequencing of genomic DNA for characterization of a satellite DNA in five species of eastern Pacific abalone.
Muchmore ME, Moy GW, Swanson WJ, Vacquier VD
Mol Mar Biol Biotechnol. 1998 Mar ; 7(1): 1-6

The abalone egg vitelline envelope receptor for sperm lysin is a giant multivalent molecule.
Swanson WJ, Vacquier VD
Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13): 6724-9

Positive Darwinian selection on two homologous fertilization proteins: what is the selective pressure driving their divergence?
Vacquier VD, Swanson WJ, Lee YH
J Mol Evol. 1997; 44 Suppl 1: S15-22

The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1.
Moy GW, Mendoza LM, Schulz JR, Swanson WJ, Glabe CG, Vacquier VD
J Cell Biol. 1996 May ; 133(4): 809-17

Liposome fusion induced by a M(r) 18,000 protein localized to the acrosomal region of acrosome-reacted abalone spermatozoa.
Swanson WJ, Vacquier VD
Biochemistry. 1995 Oct 31; 34(43): 14202-8

Extraordinary divergence and positive Darwinian selection in a fusagenic protein coating the acrosomal process of abalone spermatozoa.
Swanson WJ, Vacquier VD
Proc Natl Acad Sci U S A. 1995 May 23; 92(11): 4957-61