Primary Research

miRNA function in Stem Cells
One of the key characteristics of stem cells is their capacity to self-renew throughout the lifetime of an animal. Stem Cell self-renewing division is tightly controlled process; too little division disrupts the homeostasis of the tissue while too much can result in cancer. We and others have recently shown that miRNAs are required for germ line stem cell division in Drosophila (Hatfield et al., 2005; Shcherbata et al ., 2006). We are now in the process of identifying and analyzing the regulation of critical miRNAs in stem cell division.

Drosophila as a model for Human diseases
Most of our studies of the Notch pathway have been aimed at understanding how this pathway acts in patterning and how it interacts with other signaling pathways (Ruohola et al., 1991; Larkin et al., 1996, 1999; Tworoger et al., 1998; Jordan et al., 2000; Jordan et al ., 2005; Althauser et al., 2005; Ward et al., 2006). More recently we have discovered that Notch also acts in control of cell division (Deng et al., 2001; Schaeffer et al., 2004; Shcherbata et al., 2004; Jordan et al., 2006).

Projects

Dystroglycan function in polarity
Halyna Shcherbata, Emily Kerr, Luis Tulloch, Larissa Patterson, Karin Fischer, Betsy Gray, Kate Johnson, Christian Walker-Richards, Merle Gilbert, Volodya Shcherbatyy, Andriy Yatsenko

Notch function in polarity and cell cycle control
Valerie Schaeffer, Halyna Shcherbata, Kathie Jordan, Aliya Hashemi, Volodya Shcherbatyy, Andriy Yatsenko

FKBP
Halyna Shcherbata, Karin Fischer

cDNA microarray approach to understand integration of signaling pathways in follicle cells
Kathie Jordan, Steve Hatfield, Stuart Bower, Karin Fischer, Emily Kerr

Nuage function in translational control

Drosophila as a model for Human Diseases: Notch Pathway, Dystroglycan Pathway