Energetics of positive and negative work in vivo: an innovative apparatus for human muscle studies
Lazy or Old: Mitochondria decline in vivo in human muscle similarly with inactivity and age
Compensation for mitochondrial dysfunction preserves energy homeostasis in muscle of individuals with pre-manifest HD
Defending against age and disease
Variation in the adaptive response to oxidative stress with age and fiber type in mouse skeletal muscle
Human muscle efficiency: what do we know, how do we know it, and what we need to know
Immune responses to adeno associated virus vectors in canine muscle using MRI For Duchenne muscular dystrophy
Citations and Reviews
Citations from Faculty of 1000:
Amara et al. find that mitochondria in highly oxidative muscles in adult human subjects are more uncoupled (lower ratio of ATP produced to oxygen consumed) than less oxidative muscles.
Reviews in Faculty of 1000:
Food for Thought
Tying together the loose ends of aging
Keeping connected in old age (top 10% viewed)
Preventing muscle atrophy: is maintaining mitochondrial content not enough?
Mitochondrial dysfunction in aged skeletal muscle: the answer depends on how you ask the question.
Myosin II: a motor or a timing belt?
Genes, lifestyle and longevity: do we thank our parents or ourselves for a long life? (top 10% viewed)
Brain over brawn: does 'brain fatigue' limit exercise capacity in thin air? Editor's Choice
Recent TCMI Grants
A new TCMI project, entitled "New MR Spectroscopy Approaches for Studying Neurodegeneration at 3T" (Project Leader - Kevin Conley), a component of a larger ARRA RC4 grant application, has just received an outstanding impact score of 15 and a 1st percentile rank from the NIH review committee and is very likely to be funded by Fall 2010. For more information, click here.
A TCMI grant application, entitled "Mitochondrial-targeted antioxidants, aging and AZT in skeletal muscle dysfunction" (Project Leaders - Marcinek and Voss), a component of a larger program project, has just received an excellent score in the 1st percentile from the NIH review committee and is very likely to be funded by Fall 2010. For more information, click here.
Two recent TCMI grant applications were awarded in the Fall of 2009 by the National Institutes of Aging at NIH. Both projects were Grand Opportunity (GO) grants awarded under the National Institutes' American Recovery and Reinvestment Act (ARRA) funding program. For more information, click here.