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http://f1000biology.com/graphics/biology/f1000evaluation.gifRecommended, F1000 Factor 3.0

Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo.
Amara CE, Shankland EG, Jubrias SA, Marcinek DJ, Kushmerick MJ, Conley KE
Proc Natl Acad Sci U S A 2007 Jan 16 104(3):1057-62

Selected by | Daniel Beard, Medical College of Wisconsin, United States of America

Amara et al. find that mitochondria in highly oxidative muscles in adult human subjects are more uncoupled (lower ratio of ATP produced to oxygen consumed) than less oxidative muscles. Furthermore, they show that in elderly subjects the less oxidative muscles have a diminished energetic state (due to diminished chemical potential at which their mitochondria deliver ATP) while both muscle types are uncoupled to the same degree. Based on these findings, the authors speculate that the mild uncoupling observed in the more active muscle in adults protects the mitochondria from oxidative damage, preserving performance with age. This compelling hypothesis may have an analogue in cardiac physiology, where mitochondrial uncouplers and leak channel openers of many sorts have been shown to protect the heart from ischemic damage.

Evaluated 7 Jun 2007
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