Creating Transformational Tools For Human and Animal In Vivo Studies of Disease
About the Center
UW - South Lake Union
Faculty of 1000 Reviews
Food for Thought
Tying together the loose ends of aging
Keeping connected in old age (top 10% viewed)
Preventing muscle atrophy: is maintaining mitochondrial content not enough?
Mitochondrial dysfunction in aged skeletal muscle: the answer depends on how you ask the question.
Myosin II: a motor or a timing belt?
Genes, lifestyle and longevity: do we thank our parents or ourselves for a long life? (top 10% viewed)
Brain over brawn: does 'brain fatigue' limit exercise capacity in thin air? Editor's Choice
Lost in contraction: muscle fatigue disturbs the brain's 'body map' of limb position.
Do muscle mitochondria trigger neurodegeneration?
Does mitochondrial adaptability protect against type 2 diabetes (T2D)?
What doesn’t kill you makes you stronger: essential role of reactive oxygen species (ROS) in the benefits of exercise.
Unleashing the adaptive potential of skeletal muscle: reducing the repressor receptor interacting protein 140 (RIP140) allows activation of mitochondrial biogenesis.
Thinking in the slow lane: does reduced energy metabolism indicate lower neuronal activity in the aging brain? (Top 10% viewed)
A new mitochondrial mechanism that links high-fat diet to insulin resistance (IR) is demonstrated in this study.
The cellular mechanism governing energy starvation in cardiac overload and failure is revealed by the pairing of modelling with in vivo measurements.
In this study, reversal of cell energy failure (loss of ATP) due to a mitochondrial mutation was achieved by activating synthesis of new mitochondria.