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TCMI News


 

Recent TCMI Grants

A new TCMI project, a component of a larger ARRA RC4 grant application, has just received an outstanding impact score of 15 and a 1st percentile rank from the NIH review committee and is very likely to be funded by Fall 2010.

  • RC4 Title - IBIC: Integrated Brain Imaging Center for the University of Washington (PI - Grabowski)
    Project: New MR Spectroscopy Approaches for Studying Neurodegeneration at 3T (Project Leader - Kevin Conley)
  • This project proposes to create a new window on neurodegeneration in vivo by adapting novel MRI tools, which have revealed new concepts on degeneration mechanisms when applied to skeletal muscle studies, to develop a multi-modal approach of parallel molecular and structural imaging of the brain in vivo using recent advances in 3T MRI technology.

 

Another TCMI grant application, a component of a larger program project, has just received an excellent score in the 1st percentile from the NIH review committee and is also very likely to be funded by Fall 2010.

  • P01: Mitochondrial antioxidants and aging (PI - Rabinovitch)
    Project: Mitochondrial-targeted antioxidants, aging and AZT in skeletal muscle dysfunction (Project Leaders - Marcinek and Voss)
  • This project combines our unique non-invasive approaches to studying in vivo mitochondrial function with cutting edge mitochondrial proteomics, novel genetic models and newly developed mitochondrial- targeted drugs supported by this P01 to test whether mitochondrial- targeted antioxidants can prevent mitochondrial and muscle dysfunction associated with the ant-HIV drugs AZT/3TC (Combivir).

 

Two more recent TCMI grant applications were awarded in the Fall of 2009 by the National Institutes of Aging at NIH. Both projects were Grand Opportunity (GO) grants awarded under the National Institutes' American Recovery and Reinvestment Act (ARRA) funding program.

  • The first is a two year project entitled "Translational Center for In Vivo Mitochondrial Medicine," which will provide foundational funding for the center and facilitate collaborative studies that exploit transformational in vivo diagnostic tools to reveal the roles of mitochondria and cell energetics in cell health and disease using mouse and human muscle model systems.
  • The second is a one year study, a subcontractual component of a larger project involving the California Pacific Medical Center in San Francisco entitled "Study of Energy and Aging." This is a pilot project to evaluate mitochondrial structural and functional measures collected in vivo and in vitro from human quadriceps muscle in elderly subjects.