Bruce Tempel, Ph.D.
Professor, Departments of
Otolaryngology and Pharmacology


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The Virginia Merrill Bloedel Hearing Research Center
Box 357923
University of Washington School of Medicine
Seattle, Washington 98195-7923
Phone: 206 616 4693, FAX: 206 616 1828

Pacific Lutheran University, Tacoma, WA; B.S., 1978
Princeton University, Princeton, NJ; M.A., 1980; Ph.D., 1983

Selected Publications

Silverstein RS, Tempel BL (2006) Atp2b2, encoding plasma membrane ca(2+)-atpase type 2, exhibits tissue-specific first exon usage in hair cells, neurons, and mammary glands of mice, Neuroscience, in press.

Gittleman JX, Tempel BL (2006) Kv1.1 containing channels are critical for temporal precision during spike initiation, J. Neurophysiol., in press.

McCullough, B.J. and Tempel, B.L (2004) Haplo-insufficiency revealed in deafwaddler mice when tested for hearing loss and ataxia. Hearing Res. 195:90-102.

Lu, Y., Monsivais, P., Tempel, B.L and Rubel, E.W (2004) Activity-dependent regulation of the potassium channel subunits Kv1.1 and Kv3.1. J. Comp. Neurol. 470:93-106.

Wood, J.D., Muchinsky, S.J., Filoteo, A.G., Penniston, J.T. and Tempel, B.L (2004) Low endolymphatic calcium concentrations in deafwaddler2J mice suggest that PMCA2 contributes to endolymph calcium maintenance. JARO 5:99-110.

Kopp-Scheinpflug, C., Fuchs, K., Lippe, W.R., Tempel, B.L and Rubsamen, R. (2003) Decreased temporal precision of auditory signaling in Kcna1-null mice: An electrophysiological study in vivo. J. Neurosci. 23:9199-9207.

Lopantsev, V., Tempel, B.L and Schwartzkrion, P.A. (2003) Hyperexcitability of CA3 pyramidal cells in mice lacking the potassium channel subunit Kv1.1. Epilepsia 44:1506-1512.

Brew, H.M., Hallows, J.L., and Tempel, B.L (2003) Hyperexcitability and reduced low threshold potassium currents in auditory neurons of mice lacking the voltage-gated potassium channel subunit Kv1.1. J. Physiol. (London) 548:1-20.

Parkinson, N.J., Olsson, C.L., Hallows, J.L., McKee-Johnson, J.W., Keogh, B.P., Noben-Trauth, K., Kujawa, S.G. and Tempel, B.L (2001) Mutant beta-spectrin 4 causes auditory and motor neuropathies in quivering mice. Nature Genetics 29:61-65.

Street, V.A., McKee-Johnson, J.W., Fonseca, R.C., Tempel, B.L and Noben-Trauth, K. (1998) Mutations in a plasma membrane calcium ATPase cause deafness in deafwaddler mice. Nature Genetics 19: 390-394.

Smart, S.L., Lopantsev, V., Zhang, C.L., Robbins, C.A., Wang, H., Chiu, S.Y., Schwartzkroin, P.A., Messing, A. and Tempel, B.L (1998) Deletion of the Kv1.1 potassium channel causes epilepsy in mice. Neuron 20: 809-819.

Street, V.A., Bosma, M.M., Demas, V.P., Regan, M.R., Lin, D.D., Robinson, L.C., Agnew, W.S., and Tempel, B.L (1997) The type 1 inositol 1,4,5-triphosphate receptor gene is altered in the opisthotonos mouse. J. Neuroscience 17:635-645.

Wang, H., Allen, M.L., Grigg, J.J., Noebels, J.L., and Tempel, B.L (1995) Hypomyelination alters potassium channel expression in mouse mutants shiverer and Trembler. Neuron 15:1337-1347.

Wang, H., Kunkel, D.D., Martin, T.M., Schwartzkroin, P.A., and Tempel, B.L (1993) Heteromultimeric potassium channels in terminal and juxtaparanodal regions of neurons. Nature 365: 75-79.

Tempel, B.L, Jan, Y.N., and Jan, L.Y. (1988) Cloning of a probable potassium channel gene from mouse brain. Nature 332:837-839.

Tempel, B.L, Papazian, D.M., Schwarz, T.L., Jan, Y.N., and Jan, L.Y. (1987) Sequence of a probable potassium channel component encoded at the Shaker locus of Drosophila. Science 237:770-775.

Tempel, B.L, Bonini, N., Dawson, D.R., and Quinn, W.G. (1983) Reward learning in normal and mutant Drosophila. Proc. Nat. Acad. Sci. 80:1482-1487.