TERIS Teratogen Information System

Thomas H. Shepard, M.D.

Thomas H. Shepard

Thomas H. Shepard, M.D.
Professor Emeritus
Department of Pediatrics
University of Washington
Seattle, WA

Research Interests

  • Criteria for human teratogenesis
  • Microvillar lengthening of embryonic neuroectoderm with glucose
  • Scanning electron microscopy
  • Möbius Syndrome - pathogenesis

Education & Training

  • 1945 AB Amherst College
  • 1948 MD University of Rochester
  • 1948-52 Clinical Training in Pediatrics
  • 1954 Fellow in Pediatric Endocrinology, Johns Hopkins
  • 1961-63 Training in Teratology, University of Florida, Johns Hopkins and University of Copenhagen

Selected Publications

Shepard TH: Catalog of Teratogenic Agents, 13th ed. Baltimore, Md.: Johns Hopkins University Press, 2010.

The 13th edition of Shepard’s Catalog provides a comprehensive compilation of animal and human research on the teratogenicity of chemical and environmental agents. The Catalog contains information on over 3500 agents and includes many references for the Japanese as well as the American and European literature.

The main purpose of this Catalog is to help link the information on experimental teratogenic agents with the congenital defects in human beings. The Catalog provides a source of reference for teratologists wishing knowledge of the literature dealing with particular teratogenic agents. For the obstetrician, pediatrician, and geneticist it helps answer the often-asked question: Does this agent produce congenital defects in the human or animal? Another function of this book is to aid the scientists who protect us from our modified environment. Testing pharmaceutical products has become a major responsibility and the environmental protectionist is also faced with the safety of food additives and household products. This catalog also may be useful to chemists working to develop new products.

Shepard TH: (Letters to the Editor) “Proof” of human teratogenicity. Teratology 50(2):97-98, 1994.

Shepard TH: (Letters to the Editor) Möbius syndrome after misoprostol: a possible teratogenic mechanism. Lancet 346(8977):780, 1995.

Shepard TH, Park HW: Neural plate microvillus lengthening in rat embryos grown in various concentrations of glucose and further studies of the mechanism. Teratology 50(5):340-347, 1994.

Shepard TH: (Letters to the Editor, comments) "Proof" of human teratogenicity. Teratology 51(4):228, 1995.

Shepard TH, FitzSimmons J, Fantel AG, Pascoe-Mason J: Placental weights of normal and aneuploid early human fetuses. Pediatr Pathol 9(4):425-431, 1989.

Shepard TH: (Commentary) Möebius syndrome: animal model--human correlations and evidence for a brainstem vascular etiology. Case observation vs. epidemiology studies. Teratology 43(6):559-560, 1991.

Shepard TH: Human Teratogenicity. In: Advances in Pediatrics, Barness L (ed). Chicago: Year Book Medical Publishers, 1986, pp 225-268.

Tanimura T, Shepard TH: Glucose metabolism by rat embryos in vitro. Proc Soc Exp Biol Med 135(1):51-54, 1970.

Shepard TH: The Thyroid. In: Organogenesis, DeHaan RL, Ursprung H (eds). New York: Holt, Rinehart and Winston, 1965, pp 493-512.

Shepard TH, Gartler SM: Increased incidence of non-tasters of phenylthiocarbamide among congenital athyreotic cretins. Science 131(3404):929, 1960.

Shepard TH, Pyne GE, Kirschvink JF, McLean M: Soybean goiter--report of three cases. N Engl J Med 262(22):1099-1103, 1960.