Thomas H. Shepard, M.D. Professor Emeritus Department of Pediatrics University of Washington Box 356320 Seattle, WA 98195-6320 phone: 206 543-3373 FAX: 206 543-3184

Research Interests

• Criteria for human teratogenesis
• Microvillar lengthening of embryonic neuroectoderm with glucose
• Scanning electron microscopy
• Möbius Syndrome - pathogenesis

• 1945 AB Amherst College
• 1948 MD University of Rochester
• 1948-52 Clinical Training in Pediatrics
• 1954 Fellow in Pediatric Endocrinology, Johns Hopkins
• 1961-63 Training in Teratology, University of Florida, Johns Hopkins and University of Copenhagen

Shepard TH: A Catalog of Teratogenic Agents, 8th ed. Johns Hopkins Press, Baltimore, 1995.

The 8th edition of Shepard’s Catalog provides a comprehensive compilation of animal and human research on the teratogenicity of chemical and environmental agents. The Catalog contains inform,ation on over 2500 agents and includes many references for the Japanese as well as the American and European literature.

The main purpose of this catalog is to help link the information on experimental teratogenic agents with the congenital defects in human beings. The catalog provides a source of reference for teratologists wishing knowlege of the literature dealing with a particular teratogenic agents. For the obstetrician, pediatrican, and geneticist it helps answer the often-asked question: Does this agent produce congenital defects in the human or animal? Another function of this book is to aid the scientists who protect us from our modified environment. Testing pharmaceutical products has beocme a major responsibility and the environmental protectionist is also faced with the safety of food additives and household products. This catalog also may be useful to chemists working to develop new products.

Shepard TH: Letter to Editor: “Proof of human teratogenicity. Teratology 50:97-98, 1994.

Shepard TH: (Letter to Editor) Mobius syndrome after misoprostol: a possible teratogenic mechanism. The Lancet 246:780, 1995.

Shepard TH and Park HW: Neural plate microvillus lengthening in rat embryos grown in various concentrations of glucose and further studies of the mechanism. Teratology 50:340-3347, 1995.

Shepard TH: (Letter to Editor, on comments to “Proof of teratogenicty”) Teratology 51:228, 1995.

Shepard TH, FitzSimmons J, Fantel AG, Pascoe-Mason J: Placental weights of wormal and aneuploid early human fetuses. Pediatric Path. 9:425-431, 1989.

Shepard TH: (Commentary)--Moebius syndrome: Animal model -human correlations and evidence for a brainstem vascular etiology. Case observation vs. epidemiology studies. Teratology 43:559-560.

Shepard TH: Human Teratogenicity In: Advances in Pediatrics, Lewis Barness, ed. Year Book Medical Publishers, Chicago, 1986, pp:225-268.

Tanimura T, Shepard TH: Glucose metabolism by rat embryos in vitro. Proc. Soc. Exp. Biol. & Med. 135:51-54, 1970.

Shepard TH: The thyroid (chapter 19) pp. 493-512 In: Organogenesis, edited by R. DeHaan and H. Ursprung. Holt, Rinehart, and Winston, Inc. 1965.

Shepard TH, Gartler S: Increased incidence of non-tasters of phenylthiocarbamide among congenital arthyreotic cretins. Science 131:929, 1960.

Shepard TH, Pyne GE, Kirschvink JF, McLean MC: Soybean goiter, case reports of three children developing goiters while on soybean milk. N. Eng. J. Med. 262:1099-1103, 1960.