HER2 specific adoptive T cells shown to localize and infiltrate all sites of disease using combined SPECT and PET imaging.

Adoptive T cell therapy has been shown to stimulate anti-tumor response in multiple cancers, however these responses have
not been robust or durable. In previous studies, indium-111 labeled T cells have functioned normally but were either not present
at all sites of metastatic disease or not able to infiltrate the sites of disease. In breast cancer, adoptive HER2 targeted T cells
were unable to penetrate visceral metastases. Previous work in our laboratory has demonstrated that HER2 vaccine-primed


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