TVG Publications


Below is a list of publications by individual investigators at the UW Tumor Vaccine Group over the past two years. For prior years please click on the type of publication in the left menu then the year associated with the publication. To view the article, click on the article title.

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Original Articles

Concurrent Trastuzumab and HER2/neu-Specific Vaccination in Patients With Metastatic Breast Cancer.
Disis ML, Wallace DR, Gooley TA, Dang Y, Slota M, Lu H, Coveler AL, Childs JS, Higgins DM, Fintak PA, Dela Rosa C, Tietje K, Link J, Waisman J, Salazar LG.
J Clinical Oncology 27(28):4685-92. (Epub ahead of print 2009)  |  PubMed# 19720923

Identification of a broad coverage HLA-DR degenerate epitope pool derived from carcinoembryonic antigen
Karyampudi L, Krco CJ, Kalli KR, Erskine CL, Hartmann LC, Goodman K, Ingle JN, Maurer MJ, Nassar A, Yu C, Disis ML, Wettstein PJ, Fikes JD, Beebe M, Ishioka G, and Knutson KL
Cancer Immunol Immunother, 2009 (epub ahead of print)

Identification of immunologic biomarkers associated with clinical response after immune-based therapy for cancer
Dang Y and Disis ML
Annals of the New York Academy of Sciences 1174:81-7.  |   PubMed #19769740

Toward a stem cell gene therapy for breast cancer
Li Z, Liu Y, Tuve S, Xun Y, Fan X, Min L, Feng Q, Kiviat N, Kiem HP, Disis ML, Lieber A.
Blood 113(22): 5423-33, 2009  |   PubMed #19329780

In situ adenovirus vaccination engages T effector cells against cancer.
Tuve S, Liu Y, Tragoolpua K, Jacobs JD, Yumul RC, Li ZY, Strauss R, Hellstrom KE, Disis ML, Roffler S, Lieber A.
Vaccine 27: 4225-4239, 2009  |   PubMed #19481312

Common adjuvant breast cancer therapies do not inhibit cancer vaccine induced immunity
Coveler AL, Goodell V, Webster DJ, Salazar LG, Fintak PA, Childs JS, Higgins DM and Disis ML
Breast Cancer Research Treatment 113(1): 95-100, 2009  |   PubMed #18236151

Direct detection of carcinoembryonic antigen autoantibodies in clinical human serum samples using a surface plasmon resonance sensor
Ladd J, Lu H, Taylor AD, Goodell V, Disis ML, Jiang S
Colloids Surf B Biontefraces 70: 1-6, 2009  |   PubMed #19157807

Insulin-like growth factor-binding protein-2 is a target for the immunomodulation of breast cancer
Park KH, Gad E, Goodell V, Dang Y, Wild T, Higgins D, Fintak P, Childs J, Dela Rosa C, Disis ML
Cancer Research 68(20): 8400-9, 2008  |   PubMed #18922913

An HLA-DR-degenerate epitope pool detects insulin-like growth factor binding protein 2-specific immunity in patients with cancer
Kalli KR, Krco CJ, Hartmann LC, Goodman K, Maurer MJ, Yu C, Johnson EM, Erskine CL, Disis ML, Wettstein PJ, Fikes JD, Beebe M, Ishioka G, Knutson KL
Cancer Research 68(12): 4893-901, 2008  |   PubMed #18559537

The endogenous danger signal, crystalline uric acid, signals for enhanced antibody immunity
Behrens MD, Wagner WM, Krco CJ, Erskine CL, Kalli KR, Krempski J, Gad EA, Disis ML and Knutson KL
Blood 111(3): 1472-9, 2008  |   PubMed #18029553

His-tag ELISA for the detection of humoral tumor-specific immunity
Goodell V, McNeel D and Disis ML
BMC Immunology 9: 23, 2008  |   PubMed #18510754

Precision and linearity targets for validation of an IFNgamma ELISPOT, cytokine flow cytometry, and tetramer assay using CMV peptides
Maecker HT, Hassler J, Payne JK, Summers A, Comatas K, Ghanayem M, Morse MA, Clay TM, Lyerly HK, Bhatia S, Ghanekar SA, Maino VC, delaRosa C and Disis ML
BMC Immunology 9: 9, 2008  |   PubMed #18366814

An analytical workflow for investigating cytokine profiles
Siebert JC, Inokuma M, Waid DM, Pennock ND, Vaitaitis GM, Disis ML, Dunne JF, Wagner DH and Maecker HT
Cytometry A 73(4): 289-98, 2008  |   PubMed #18163472

Level of HER-2/neu protein expression in breast cancer may affect the development of endogenous HER-2/neu-specific immunity
Goodell V, Waisman J, Salazar LG, dela Rosa C, Link J, Coveler AL, Webster W, Childs JS, Fintak PA, Higgins DM and Disis ML
Molecular Cancer Theraputics 7(3): 449-54, 2008  |   PubMed #18319334

Humoral immunity directed against tumor associated antigens as potential biomarkers for the early diagnosis of cancer
Lu H, Goodell V, and Disis ML
Proteome Res 7: 1388-94, 2008  |   PubMed #18311901

 

Review Articles

Use of tumour-responsive T cells as cancer treatment
Disis ML, Bernhard H, Jaffee EM.
Lancet. 373(9664): 673-83, 2009  |   PubMed #19231634

A systematic approach to biomarker discovery; Preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers"
Butterfield LH, Disis ML, Fox BA, Lee PP, Khleif SN, Thurin M, Trinchieri G, Wang E, Wigginton J, Chaussabel D, Coukos G, Dhodapkar M, Hakansson L, Janetzki S, Kleen TO, Kirkwood JM, Maccalli C, Maecker H, Maio M, Malyguine A, Masucci G, Palucka AK, Potter DM, Ribas A, Rivoltini L, Schendel D, Seliger B, Selvan S, Slingluff CL Jr, Stroncek DF, StreicherH, Wu X, Zeskind B, Zhao Y, Zocca MB, Zwierzina H, Marincola FM.
J Translational Medicine. 6: 81, 2008  |   PubMed #19105846

Translational Research Working Group developmental pathway for immune response modifiers.
Cheever MA, Schlom J, Weiner LM, Lyerly HK, Disis ML, Greenwood A, Grad O, Nelson WG; Translational Research Working Group.
Clinical Cancer Res. 14(18): 5692-9, 2008  |   PubMed #18794077

Tumor stromal barriers to the success of adoptive T cell therapy
Phan V and Disis ML
Cancer Immunol Immunother 57(2): 281-3, 2008  |   PubMed #17646987

Immune modulation as a therapeutic strategy for non-small-cell lung cancer
Holt GE and Disis ML
Clin Lung Cancer Suppl 1: S13-9, 2008  |   PubMed #18540530

Cellular immune strategies for cancer therapy
Disis ML, Jaffe EM and Bernhard H
Lancet (in press), 2008  |   Not Published Yet

 

Methods from Our Lab

Maximizing the retention of antigen specific lymphocyte function after cryopreservation
Disis, M.L., dela rosa, C., Goodell, V., Kuan, L., Chang J. C.C., Kuus-Reichel, K., clay, T.M., Lyerly, K., Bhatia, S., Ghanekar, S.A., Maino, V.C., Maecker, H.T.
Journal of Immunological Methods 308 (2006) 13 - 18

PBMC cryopreservation using human serum albumin
The Tumor Vaccine Group
*This is the standard operation procedure document used in "Maximizing the retention of antigen specific lymphocyte function after cryopreservation"*
referenced in: Journal of Immunological Methods xxx, xxx-xxx, 2005.

Human tumor cell lysates as a protein source for the detection of cancer antigen specific humoral immunity.
Goodell V, Disis ML
Journal of Immunological Methods 299 (2005) 129– 138

Impact of cryopreservation on tetramer, cytokine flow cytometry, and ELISPOT
Maecker HT, Moon J, Bhatia S, Ghanekar SA, Maino VC, Payne JK, Kuus-Reichel K, Chang J, Summers A, Clay TM, Morse MA, Lyerly HK, delaRosa C, Ankerst DP, Disis ML
BMC Immunology 2005, 6:17

Please see the Immunologic Monitoring Laboratory for our most up to date methods.