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University of Washington Department of Urology Seal University of Washington | School of Medicine
Department of Urology
University of Washington | School of Medicine
Department of Urology

Kanchan Chitaley, PhD

Research Assistant Professor
Department of Urology
School of Medicine
University of Washington

Education

Dr. Chitaley received her PhD from the Department of Physiology at the University of Michigan under the guidance of the internationally known hypertension expert, Dr. Clinton Webb. Her post-doctoral training was conducted at the Department of Surgery at the University of Washington under the mentorship of the Dr. Alexander Clowes.

Research Interests

>>Wessells/Chitaley Lab

Dr. Chitaley's research background is in mechanisms of vascular contraction, migration and proliferation, especially as they pertain to pathologies such as hypertension, restenosis and erectile dysfunction.

Dr. Chitaley is currently collaborating with Hunter Wessells, MD, an established researcher, and clinical surgeon with expertise in urogenital trauma, reconstructive surgery and erectile dysfunction. Together, Drs Chitaley and Wessells aim to combine expertise in basic science and clinical medicine to elucidate the mechanism(s) underlying diabetes-associated erectile dysfunction, and identify potential novel therapeutic targets.

Dr. Chitaley is currently funded through the NIDDK (NIH) with a pilot and feasibility grant aimed at testing the general hypothesis that decreased levels of the adipokine, adiponectin, in type II diabetes, contributes to attenuated penile endothelial function and erectile dysfunction associated with this disease state, using db/db mice and in vitro models.

Through the partnership with Dr. Wessells, Dr. Chitaley is also actively involved in researching the role of increased levels of the copper binding protein, ceruloplasmin, in penile endothelial dysfunction during diabetes. They are currently using overexpression techniques, as well as loss of function strategies involving the use of ceruloplasmin-knockout mice in these studies.

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Affiliations:

Dr. Chitaley is a member of the American Physiologic Society and is an Ad-hoc reviewer for the American Journal of Physiology: Heart and Circulatory Physiology, the Journal of Pharmacology and Experimental Therapeutics, the Journal of Urology, International Journal of Impotence Research, the British Journal of Pharmacology, and Hypertension.

Honors:

She has more than 20 publications or book chapters and has presented her work at national and international conferences. Dr. Chitaley has also been the recipient of young investigator awards from the American Physiological Society and Merck, as well as awards from the Sexual Medicine Society, International Society for Impotence Research, American Society for Investigative Pathology, the University of Washington, and the Medical College of Georgia.

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Selected Publications:

Wessells H, Teal TH, Engel K, Sullivan CJ, Gallis B, Tran KB, Chitaley K. Fluid shear stress-induced nitric oxide production in human cavernosal endothelial cells: inhibition by hyperglycemia. BJU International. In press for May, 2006.
[The following link will open a new window. PubMed Abstract]

Chitaley K, Wessells H. Vascular Mechanisms of Erectile Dysfunction. Drug Discovery Today: Disease Mechanism. 12:1-5, 2004.
[The following link will open a new window. ScienceDirect]

Bivalacqua TJ, Champion HC, Usta MF, Cellek S, Chitaley K, Webb RC, Lewis RL, Mills TM, Hellstrom WJG, Kadowitz PJ. RhoA/Rho-kinase Suppresses Endothelial Nitric Oxide Synthase in the Penis: Novel Mechanism for Diabetic Associated Erectile Dysfunction. Proceeding of the National Academy of Sciences 101:9121-9126, 2004.
[The following link will open a new window. PubMed Abstract]

Chen L, Daum G, Chitaley K, Coats SA, Bowen-Pope DF, Eigenthaler M, Thumati NR, Walter U and Clowes AW. Vasodilator-stimulated phosphoprotein regulates proliferation and growth inhibition by nitric oxide in vascular smooth muscle cells. Atherosclerosis, Thrombosis and Vascular Biology 24:1403-1408, 2004.
[The following link will open a new window. PubMed Abstract]

Chitaley K, Chen L, Galler A, Walter U, Daum G, Clowes A. vasodilator-stimulated phosphoprotein is a substrate for protein kinase C. FEBS Letters 556:211-215, 2004.
[The following link will open a new window. PubMed Abstract]

Dai Y, Chitaley K, Webb RC, Lewis RW, Mills TM. Topical Application of a Rho-kinase Inhibitor in Rats Causes Penile Erection. International Journal of Impotence Research 16:294-298, 2004.
[The following link will open a new window. PubMed Abstract]

Chitaley K, Webb RC, Mills TM. The Ups and Downs of Rho-kinase and Penile Erection: Upstream Regulators and Downstream Substrates of Rho-kinase and their Potential Role in the Erectile Response. International Journal of Impotence Research 15:105-109, 2003.
[The following link will open a new window. PubMed Abstract]

Chitaley K, Bivalacqua TJ, Champion HC, Usta MF, Hellstrom WJ, Mills TM, Webb RC. Adeno-associated viral gene transfer of dominant negative RhoA enhances erectile function in rats. Biochemical and Biophysical Research Communications 298:427-432, 2002.
[The following link will open a new window. PubMed Abstract]

Chitaley K, Webb RC. Microtubule Microtubule depolymerization facilitates contraction of rat aorta via activation of Rho-kinase. Vascular Pharmacology 38:157-161, 2002.
[The following link will open a new window. PubMed Abstract]

Mills TM, Chitaley K, Lewis R, Webb RC. Nitric Oxide Inhibits RhoA/Rho-kinase Signaling to Cause Penile Erection. European Journal of Pharmacology 439:173-174, 2002.
[The following link will open a new window. PubMed Abstract]

Curriculum Vitae [44K PDF*]

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Portrait of Dr. Kanchan Chitaley

Contact Information:

Department of Urology
Box 359668
University of Washington
Seattle, WA 98195-6510
Ph: (206)-341-5440
Fax: (206)-341-5442