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University of Washington Department of Urology Seal University of Washington | School of Medicine
Department of Urology
University of Washington | School of Medicine
Department of Urology

COLM MORRISSEY, PHD

Acting Assistant Professor
Department of Urology
School of Medicine
University of Washington

Research Interests

>> Genitourinary Cancer Research Laboratory

  • Elucidate the processes that contribute to the osteoblastic and osteolytic response in prostate cancer bone metastasis
  • Establish new models of prostate cancer bone metastasis
  • Target angiogenic factors and tumor initiating cells in prostate cancer metastasis
  • Prostate cancer, anti-oxidants and ageing

Education & Training

Dr. Morrissey received his Ph.D. in Cell and Molecular Biology in 1999 from University College Dublin, Ireland. His research under Dr. Martin Tenniswood at the W. Alton Jones Cell Science Center, Lake Placid, NY focused on the prostate, anti-oxidants, and ageing. He taught for a year at the University of Notre Dame, South Bend, IN and then took up a postdoctoral position focusing on phytoestrogens and prostate cancer with Dr. Bill Watson at the Mater Misericordiae University Hospital, in Dublin, Ireland. He came to the University of Washington to do a postdoctoral fellowship with Dr. Robert Vessella on prostate cancer bone metastasis.

Affiliations

American Association for Cancer Research
American Association for Bone and Mineral Research

Dr Morrissey is a reviewer for the European Journal of Cancer Prevention and an Ad-hoc reviewer for a number of other Cancer journals.

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Selected Publications:

O’Sullivan J, Sheridan J, Mulcahy H, Tenniswood M, Morrissey C. The effect of green tea on oxidative damage and tumour formation in Lobund-Wistar rats. Eur J Cancer Prev. 2008 In Press.

Roudier MP, Morrissey C, True LD, Higano CS, Vessella RL, Ott SM. Assessment of prostate Cancer Bone “Osteoblastic” Metastasis Features: Histologic Evidence of Major Osteolysis and Predominantly Woven Bone with Osteoblast Precursors. J. Urol. 2008 In Press.

Lucas JM, True L, Hawley S, Matsumura M, Morrissey C, Vessella RL, Nelson PS. The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma. J Pathol. 2008 Jun;215(2):118-25.
[The following link will open a new window. PubMed Abstract]

Morrissey C, True LD, Roudier MP, Coleman IM, Hawley S, Wang Y, Corey E, Lange PH, Higano CS, Nelson PS, Vessella RL. Differential expression of angiogenesis associated genes in prostate cancer bone, liver and lymph node metastases. Clin Exp Metastasis. 2007 Oct 31; [Epub ahead of print].
[The following link will open a new window. PubMed Abstract]

Gill C, Walsh SE, Morrissey C, Fitzpatrick JM, Watson RW. Resveratrol sensitizes androgen independent prostate cancer cells to death-receptor mediated apoptosis through multiple mechanisms. Prostate. 2007 Sep 6;67(15):1641-1653.
[The following link will open a new window. PubMed Abstract]

Morrissey C, Kostenuik PJ, Brown LG, Vessella RL, Corey E. Host-derived RANKL is responsible for osteolysis in a C4-2 human prostate cancer xenograft model of experimental bone metastases. BMC Cancer. 2007 Aug 3;7(1):148.
[The following link will open a new window. PubMed Abstract]

Long RM, Morrissey C, Walsh S, Hamilton HJ, Farrell N, O’Neill A, Fitzpatrick JM, Watson RW. Alterations in the expression of inhibitors of apoptosis during differentiation of prostate epithelial cells. BJU Int. 2007 Aug;100(2):445-9.
[The following link will open a new window. PubMed Abstract]

Morrissey C and Vessella RL. The role of tumor microenvironment in prostate cancer bone metastasis. Journal of Cellular Biochemistry. J Cell Biochem. 2007 Jul 1;101(4):873-86.
[The following link will open a new window. PubMed Abstract]

Morrissey C, Brown M, O’Sullivan J, Weathered N, Watson RW, Tenniswood M. Epigallocatechin-3-gallate and bicalutamide cause growth arrest and apoptosis in NRP-152 and NRP-154 prostate epithelial cells. Int J Urol. 2007 Jun;14(6):545-51.
[The following link will open a new window. PubMed Abstract]

McCrohan A, Morrissey C, O’Keane C, Mulligan N, Watson C, Smith J, Fitzpatrick JM, Watson RW. Effects of the dual 5 alpha-reductase inhibitor Dutasteride on apoptosis in primary cultures of prostate cancer epithelial cells and cell lines. Cancer. 2006 Jun 15;106(12):2743-52.
[The following link will open a new window. PubMed Abstract]

Morrissey C, O’Neill A, Spengler B, Christoffel V, Fitzpatrick JM, Watson RWG. Apigenin drives the production of reactive oxygen species and initiates a mitochondrial mediated cell death pathway in prostate epithelial cells. Prostate. 2005 May 1;63(2):131-42.
[The following link will open a new window. PubMed Abstract]

Coffey RN, Morrissey C, Taylor CT, Fitzpatrick JM, Watson RW. Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells. Cancer. 2005 Apr 1;103(7):1363-74.
[The following link will open a new window. PubMed Abstract]

Long RM, Morrissey C, Fitzpatrick JM, Watson RW. Prostate epithelial cell differentiation and its relevance to the understanding of prostate cancer therapies. Clin Sci (Lond). 2005 Jan;108(1):1-11.
[The following link will open a new window. PubMed Abstract]

Curriculum Vitae [31K PDF*]

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photo of Colm Morrissey, MD

Contact Information:

University of Washington Medical Center
Box 356510
1959 N.E. Pacific
Seattle, WA 98195