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University of Washington Department of Urology Seal University of Washington | School of Medicine
Department of Urology
University of Washington | School of Medicine
Department of Urology

Thomas K. Takayama, MD

Associate Professor
Departments of Urology
School of Medicine
University of Washington

>>Takayama lab

Specialty / Expertise

Dr. Takayama is an expert in Urologic Cancer Surgery. He routinely performs daVinci Robot-assisted laparoscopic radical prostatectomy for prostate cancer and laparoscopic surgery including radiofrequency-ablation for kidney cancer. He has also won numerous awards to study prostate cancer (National Institutes of Health, Department of Defense, American Cancer Society grants).

Common Surgeries Performed

Common Diseases Treated

Training

Dr. Takayama graduated from Tufts University School of Medicine in Boston and finished Urologic training at the University of Washington (UW) in 1993. He then completed UW Fellowship training in advanced urologic cancer surgery in 1995. He also received Mentored-Scientist Training from Dr. Earl W. Davie of the UW Department of Biochemistry (1995-1999). He is board certified by the American Board of Urology.

Professional Organizations

Member of the Society of Urologic Oncology (SU0), American Urological Association, Western Section of the American Urological Association, Northwest Urological Society, Seattle Surgical Society.

Selected Publications:

Mize GJ, Wang W, Takayama TK. Prostate-Specific Kallikreins-2 and -4 Enhance the Proliferation of DU-145 Prostate Cancer Cells through Protease-Activated Receptors-1 and -2. Mol Cancer Res. 2008 Jun;6(6):1043-51.
[The following link will open a new window. PubMed Abstract]

Wang W, Zhang X, Mize GJ, Takayama TK. Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia. Prostate. 2008 Jul 1;68(10):1064-75.
[The following link will open a new window. PubMed Abstract]

Mize GJ, Harris JE, Takayama TK, Kulman JD. Regulated expression of active biotinylated G-protein coupled receptors in mammalian cells. Protein Expr Purif. 2008 Feb;57(2):280-9.
[The following link will open a new window. PubMed Abstract]

Kenerson H, Folpe AL, Takayama TK, Yeung RS. Activation of the mTOR pathway in sporadic angiomyolipomas and other perivascular epithelioid cell neoplasms. Hum Pathol. 2007 Sep;38(9):1361-71.
[The following link will open a new window. PubMed Abstract]

Black PC, Mize GJ, Karlin P, Greenberg DL, Hawley SJ, True LD, Vessella RL, and Takayama TK. Overexpression of protease-activated receptors-1,-2, and-4 (PAR-1, -2, and -4) in prostate cancer. Prostate. 2007 May 15;67(7):743-56.
[The following link will open a new window. PubMed Abstract]

Dighe M, Takayama T, and Bush WH Jr. Preoperative planning for renal cell carcinoma--benefits of 64-slice CT imaging. Int Braz J Urol. 2007 May-Jun;33(3):305-12.
[The following link will open a new window. PubMed Abstract]

Sim HG, Kliot M, Lange PH, Ellis WJ, Takayama TK, and Yang CC. Two-year outcome of unilateral sural nerve interposition graft after radical prostatectomy. Urology. 2006 Dec;68(6):1290-4.
[The following link will open a new window. PubMed Abstract]

Cuevas C, Raske M, Bush WH, Takayama T, Maki JH, Kolokythas O, and Meshberg E. Imaging primary and secondary tumor thrombus of the inferior vena cava: multi-detector computed tomography and magnetic resonance imaging. Curr Probl Diagn Radiol. 2006 May-Jun;35(3):90-101.
[The following link will open a new window. PubMed Abstract]

Matsumura M, Bhatt AS, Andress D, Clegg N, Takayama TK, Craik CS, Nelson PS. Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries. Prostate. 2005 Jan 1;62(1):1-13.
[The following link will open a new window. PubMed Abstract]

Black PC, Lange PH, Takayama TK. Extensive palliative surgery for advanced mesothelioma of the tunica vaginalis. Urology. 2003 Oct;62(4):748.
[The following link will open a new window. PubMed Abstract]

Greenberg DL, Mize GJ, Takayama TK. Protease-activated receptor mediated RhoA signaling and cytoskeletal reorganization in LNCaP cells. Biochemistry. 2003 Jan 28;42(3):702-9.
[The following link will open a new window. PubMed Abstract]

Cooley J, Takayama TK, Shapiro SD, Schechter NM, Remold-O'Donnell E. The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites. Biochemistry. 2001 Dec 25;40(51):15762-70.
[The following link will open a new window. PubMed Abstract]

Takayama TK, McMullen BA, Nelson PS, Matsumura M, Fujikawa K. Characterization of hK4 (prostase), a prostate-specific serine protease: activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase. Biochemistry. 2001 Dec 18;40(50):15341-8.
[The following link will open a new window. PubMed Abstract]

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Portrait of Dr. Thomas K. Takayama

Contact Information:

University of Washington Medical Center
Box 356510
1959 N.E. Pacific
Seattle, WA 98195-6510