Profile

Patient Care Philosophy
New discoveries, established guidelines and the individual patient will always require a phsyician who practices the 'art' of medicine.

Personal Interests
Reading, skiing, backpacking, tennis

Clinical Interests
Genitourinary oncology (research and clinical), tumor markers, reconstructive urologic surgery

Languages
English

Expertise
Urology

Education & Training

Education History

Board Certifications

Selected Publications

Publications

• Wright JL, Dalkin BL, True LD, Ellis WJ, Stanford JL, Lange PH, Lin DW "Positive surgical margins at radical prostatectomy predict prostate cancer specific mortality." The Journal of urology 2010 Jun; 183; 6; 2213-8
  
  
• Lange PH "Words of wisdom. Re: Phase 1 trial of high-dose exogenous testosterone in patients with castration-resistant metastatic prostate cancer. Morris MJ, Huang D, Kelly WK, et al. Eur Urol 2009;56:237-44." European urology 2010 Aug; 58; 2; 311-2
  
  
• Lange PH "Editorial comment." Urology 2010 Feb; 75; 2; 405; author reply 405-6
  
  
• Lange PH "The future of urologic oncology: "Proceduralists" or continued leaders?" Urologic oncology 2009 Mar-Apr ; 27; 2; 118-9
  
  
• Morgan TM, Lange PH, Porter MP, Lin DW, Ellis WJ, Gallaher IS, Vessella RL "Disseminated tumor cells in prostate cancer patients after radical prostatectomy and without evidence of disease predicts biochemical recurrence." Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Jan; 15; 2; 677-83
  
  
• Lange PH "Words of wisdom. Re: Adjuvant radiotherapy for patients with locally advanced prostate cancer--a new standard?" European urology 2009 Feb; 55; 2; 524-5
  
  
• Qian DZ, Huang CY, O'Brien CA, Coleman IM, Garzotto M, True LD, Higano CS, Vessella R, Lange PH, Nelson PS, Beer TM "Prostate cancer-associated gene expression alterations determined from needle biopsies." Clinical cancer research : an official journal of the American Association for Cancer Research 2009 May; 15; 9; 3135-42
  
  
• Lange PH "Editorial comment on: Prostate cancer detection rate in patients with repeated extended 21-sample needle biopsy." European urology 2009 Mar; 55; 3; 609
  
  
• Sim HG, Telesca D, Culp SH, Ellis WJ, Lange PH, True LD, Lin DW "Tertiary Gleason pattern 5 in Gleason 7 prostate cancer predicts pathological stage and biochemical recurrence." The Journal of urology 2008 May; 179; 5; 1775-9
  
  
• Morrissey C, True LD, Roudier MP, Coleman IM, Hawley S, Nelson PS, Coleman R, Wang YC, Corey E, Lange PH, Higano CS, Vessella RL "Differential expression of angiogenesis associated genes in prostate cancer bone, liver and lymph node metastases." Clinical & experimental metastasis 2008 ; 25; 4; 377-88
  
  
• Lange PH "The future of urological oncology: proceduralists or continued primary physicians and leaders." The Journal of urology 2008 Jun; 179; 6; 2085-6
  
  
• Pfitzenmaier J, Ellis WJ, Hawley S, Arfman EW, Klein JR, Lange PH, Vessella RL "The detection and isolation of viable prostate-specific antigen positive epithelial cells by enrichment: a comparison to standard prostate-specific antigen reverse transcriptase polymerase chain reaction and its clinical relevance in prostate cancer." Urologic oncology 2007 May-Jun ; 25; 3; 214-20
  
  
• Lange PH "Genitourinary oncology and its surgeon scientists: triumphant past, but does it have a future?" Urologic oncology 2007 Jan-Feb ; 25; 1; 2-10
  
  
• Morgan TM, Lange PH, Vessella RL "Detection and characterization of circulating and disseminated prostate cancer cells." Frontiers in bioscience : a journal and virtual library 2007 ; 12; ; 3000-9
  
  
• Huang CY, Beer TM, Higano CS, True LD, Vessella R, Lange PH, Garzotto M, Nelson PS "Molecular alterations in prostate carcinomas that associate with in vivo exposure to chemotherapy: identification of a cytoprotective mechanism involving growth differentiation factor 15." Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Oct; 13; 19; 5825-33
  
  
• Wright JL, Lange PH "Newer potential biomarkers in prostate cancer." Reviews in urology 2007 Fall; 9; 4; 207-13
  
  
• Sim HG, Lange PH, Lin DW "Role of post-chemotherapy surgery in germ cell tumors." The Urologic clinics of North America 2007 May; 34; 2; 199-217; abstract ix
  
  
• Sim HG, Kliot M, Lange PH, Ellis WJ, Takayama TK, Yang CC "Two-year outcome of unilateral sural nerve interposition graft after radical prostatectomy." Urology 2006 Dec; 68; 6; 1290-4
  
  
• Pfitzenmaier J, Ellis WJ, Arfman EW, Hawley S, McLaughlin PO, Lange PH, Vessella RL "Telomerase activity in disseminated prostate cancer cells." BJU international 2006 Jun; 97; 6; 1309-13
  
  
• Berry DL, Ellis WJ, Russell KJ, Blasko JC, Bush N, Blumenstein B, Lange PH "Factors that predict treatment choice and satisfaction with the decision in men with localized prostate cancer." Clinical genitourinary cancer 2006 Dec; 5; 3; 219-26
  
  
• Wright JL, Porter MP, Li CI, Lange PH, Lin DW "Differences in survival among patients with urachal and nonurachal adenocarcinomas of the bladder." Cancer 2006 Aug; 107; 4; 721-8
  
  
• Porter MP, Stanford JL, Lange PH "The distribution of serum prostate-specific antigen levels among American men: implications for prostate cancer prevalence and screening." The Prostate 2006 Jul; 66; 10; 1044-51
  
  
• Black PC, Lange PH "Cystoprostatectomy and neobladder construction for florid cystitis glandularis." Urology 2005 Jan; 65; 1; 174
  
  
• Porter MP, Lange PH "Controversies in the surgical management of renal cancer." Journal of the National Comprehensive Cancer Network : JNCCN 2005 Jan; 3; 1; 95-102
  
  
• Ellis WJ, Pfitzenmaier J, Colli J, Arfman E, Lange PH, Vessella RL "Detection and isolation of prostate cancer cells from peripheral blood and bone marrow." Urology 2003 Feb; 61; 2; 277-81
  
  
• Black PC, Lange PH, Takayama TK "Extensive palliative surgery for advanced mesothelioma of the tunica vaginalis." Urology 2003 Oct; 62; 4; 748
  
  
• Melchior SW, Noteboom J, Gillitzer R, Lange PH, Blumenstein BA, Vessella RL "The percentage of free prostate-specific antigen does not predict extracapsular disease in patients with clinically localized prostate cancer before radical prostatectomy." BJU international 2001 Aug; 88; 3; 221-5
  
  
• Brown JM, Vessella RL, Kostenuik PJ, Dunstan CR, Lange PH, Corey E "Serum osteoprotegerin levels are increased in patients with advanced prostate cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 2001 Oct; 7; 10; 2977-83
  
  
• Vessella RL, Wilbur DS, Buhler K, Lange PH "Experimental models and methods in antibody targeting of renal cell carcinoma." Methods in molecular medicine 2001 ; 53; ; 217-42
  
  
• Thomas R, True LD, Lange PH, Vessella RL "Placental bone morphogenetic protein (PLAB) gene expression in normal, pre-malignant and malignant human prostate: relation to tumor development and progression." International journal of cancer. Journal international du cancer 2001 Jul; 93; 1; 47-52
  
  
• McNeel DG, Nguyen LD, Ellis WJ, Higano CS, Lange PH, Disis ML "Naturally occurring prostate cancer antigen-specific T cell responses of a Th1 phenotype can be detected in patients with prostate cancer." The Prostate 2001 May; 47; 3; 222-9
  
  
• McNeel DG, Nguyen LD, Storer BE, Vessella R, Lange PH, Disis ML "Antibody immunity to prostate cancer associated antigens can be detected in the serum of patients with prostate cancer." The Journal of urology 2000 Nov; 164; 5; 1825-9
  
  
• Krieger JN, Riley DE, Vesella RL, Miner DC, Ross SO, Lange PH "Bacterial dna sequences in prostate tissue from patients with prostate cancer and chronic prostatitis." The Journal of urology 2000 Oct; 164; 4; 1221-8
  
  
• Buhler KR, Santucci RA, Royai RA, Whitney SC, Vessella RL, Lange PH, Ellis WJ "Intermittent androgen suppression in the LuCaP 23.12 prostate cancer xenograft model." The Prostate 2000 Apr; 43; 1; 63-70
  
  
• Lin DW, Santucci RA, Mayo ME, Lange PH, Mitchell ME "Urodynamic evaluation and long-term results of the orthotopic gastric neobladder in men." The Journal of urology 2000 Aug; 164; 2; 356-9
  
  
• Vessella RL, Lange PH, Partin AW, Chan DW, Sokoll LJ, Sasse EA, Crawford ED "Probability of prostate cancer detection based on results of a multicenter study using the AxSYM free PSA and total PSA assays." Urology 2000 Jun; 55; 6; 909-14
  
  
• Thomas R, True LD, Bassuk JA, Lange PH, Vessella RL "Differential expression of osteonectin/SPARC during human prostate cancer progression." Clinical cancer research : an official journal of the American Association for Cancer Research 2000 Mar; 6; 3; 1140-9
  
  
• Santucci RA, Park CH, Mayo ME, Lange PH "Continence and urodynamic parameters of continent urinary reservoirs: comparison of gastric, ileal, ileocolic, right colon, and sigmoid segments." Urology 1999 Aug; 54; 2; 252-7
  
  
• Liu AY, True LD, LaTray L, Ellis WJ, Vessella RL, Lange PH, Higano CS, Hood L, van den Engh G "Analysis and sorting of prostate cancer cell types by flow cytometry." The Prostate 1999 Aug; 40; 3; 192-9
  
  
• Lange PH, Vessella RL "Mechanisms, hypotheses and questions regarding prostate cancer micrometastases to bone." Cancer metastasis reviews 1998-1999 ; 17; 4; 331-6
  
  
• Lin DW, Noteboom JL, Blumenstein BA, Ellis WJ, Lange PH, Vessella RL "Serum percent free prostate-specific antigen in metastatic prostate cancer." Urology 1998 Sep; 52; 3; 366-71
  
  
• Brown LG, Wegner SK, Wang H, Buhler KR, Arfman EW, Lange PH, Vessella RL "A novel monoclonal antibody 107-1A4 with high prostate specificity: generation, characterization of antigen expression, and targeting of human prostate cancer xenografts." Prostate cancer and prostatic diseases 1998 Jun; 1; 4; 208-215
  
  
• Ellis WJ, Vessella RL, Corey E, Arfman EW, Oswin MM, Melchior S, Lange PH "The value of a reverse transcriptase polymerase chain reaction assay in preoperative staging and followup of patients with prostate cancer." The Journal of urology 1998 Apr; 159; 4; 1134-8
  
  
• Lange PH "Is screening for prostate cancer the current gold standard?--"yes"." European journal of cancer (Oxford, England : 1990) 1997 Mar; 33; 3; 354-6
  
  
• Liu AY, True LD, LaTray L, Nelson PS, Ellis WJ, Vessella RL, Lange PH, Hood L, van den Engh G "Cell-cell interaction in prostate gene regulation and cytodifferentiation." Proceedings of the National Academy of Sciences of the United States of America 1997 Sep; 94; 20; 10705-10
  
  
• Santucci RA, True LD, Lange PH "Is partial cystectomy the treatment of choice for mucinous adenocarcinoma of the urachus?" Urology 1997 Apr; 49; 4; 536-40
  
  
• Liu AY, Corey E, Vessella RL, Lange PH, True LD, Huang GM, Nelson PS, Hood L "Identification of differentially expressed prostate genes: increased expression of transcription factor ETS-2 in prostate cancer." The Prostate 1997 Feb; 30; 3; 145-53
  
  
• Vessella RL, Lange PH "Issues in the assessment of prostate-specific antigen immunoassays. An update." The Urologic clinics of North America 1997 May; 24; 2; 261-8
  
  
• Ellis WJ, Vessella RL, Noteboom JL, Lange PH, Wolfert RL, Rittenhouse HG "Early detection of recurrent prostate cancer with an ultrasensitive chemiluminescent prostate-specific antigen assay." Urology 1997 Oct; 50; 4; 573-9
  
  
• Higano CS, Ellis W, Russell K, Lange PH "Intermittent androgen suppression with leuprolide and flutamide for prostate cancer: a pilot study." Urology 1996 Nov; 48; 5; 800-4
  
  
• Liu AY, Corey E, Bladou F, Lange PH, Vessella RL "Prostatic cell lineage markers: emergence of BCL2+ cells of human prostate cancer xenograft LuCaP 23 following castration." International journal of cancer. Journal international du cancer 1996 Jan; 65; 1; 85-9
  
  
• Royai R, Lange PH, Vessella R "Preclinical models of prostate cancer." Seminars in oncology 1996 Dec; 23; 6 Suppl 14; 35-40
  
  
• Bladou F, Vessella RL, Buhler KR, Ellis WJ, True LD, Lange PH "Cell proliferation and apoptosis during prostatic tumor xenograft involution and regrowth after castration." International journal of cancer. Journal international du cancer 1996 Sep; 67; 6; 785-90
  
  
• Ellis WJ, Vessella RL, Buhler KR, Bladou F, True LD, Bigler SA, Curtis D, Lange PH "Characterization of a novel androgen-sensitive, prostate-specific antigen-producing prostatic carcinoma xenograft: LuCaP 23." Clinical cancer research : an official journal of the American Association for Cancer Research 1996 Jun; 2; 6; 1039-48
  
  
• Marsh CL, Lange PH "Rationale for total nephrectomy for suspected renal cell carcinoma." Seminars in urologic oncology 1995 Nov; 13; 4; 273-80
  
  
• Takayama TK, Lange PH "Radiation therapy for local recurrence of prostate cancer after radical prostatectomy." The Urologic clinics of North America 1994 Nov; 21; 4; 687-700
  
  
• Takayama TK, Vessella RL, Lange PH "Newer applications of serum prostate-specific antigen in the management of prostate cancer." Seminars in oncology 1994 Oct; 21; 5; 542-53
  
  
• Marsh CL, Lange PH "Application of liver transplant and organ procurement techniques to difficult upper abdominal urological cases." The Journal of urology 1994 Jun; 151; 6; 1652-6
  
  
• Takayama TK, Vessella RL, Brawer MK, True LD, Noteboom J, Lange PH "Urinary prostate specific antigen levels after radical prostatectomy." The Journal of urology 1994 Jan; 151; 1; 82-7
  
  
• Ellis WJ, Lange PH "Prostate cancer." Endocrinology and metabolism clinics of North America 1994 Dec; 23; 4; 809-24
  
  
• Lange PH "Future studies in localized prostate cancer. What should we think? What can we do?" The Journal of urology 1994 Nov; 152; 5 Pt 2; 1932-8
  
  
• Vessella RL, Lange PH "Issues in the assessment of PSA immunoassays." The Urologic clinics of North America 1993 Nov; 20; 4; 607-19
  
  
• Lange PH "The next era for prostate cancer. Controlled clinical trials." JAMA : the journal of the American Medical Association 1993 Jan; 269; 1; 95-6
  
  
• Takayama TK, Vessella RL, Lange PH "A brief review of ultrasensitive prostate-specific antigen assays for the evaluation of patients after radical prostatectomy." World journal of urology 1993 ; 11; 4; 192-5
  
  
• Brawer MK, Beatie J, Wener MH, Vessella RL, Preston SD, Lange PH "Screening for prostatic carcinoma with prostate specific antigen: results of the second year." The Journal of urology 1993 Jul; 150; 1; 106-9
  
  
• Takayama TK, Vessella RL, Brawer MK, Noteboom J, Lange PH "The enhanced detection of persistent disease after prostatectomy with a new prostate specific antigen immunoassay." The Journal of urology 1993 Aug; 150; 2 Pt 1; 374-8
  
  
• Thompson JA, Shulman KL, Benyunes MC, Lindgren CG, Collins C, Lange PH, Benz LA, Fefer A "Prolonged continuous intravenous infusion interleukin-2 and lymphokine-activated killer-cell therapy for metastatic renal cell carcinoma." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1992 Jun; 10; 6; 960-8
  
  
• Brawer MK, Chetner MP, Beatie J, Buchner DM, Vessella RL, Lange PH "Screening for prostatic carcinoma with prostate specific antigen." The Journal of urology 1992 Mar; 147; 3 Pt 2; 841-5
  
  
• Vessella RL, Noteboom J, Lange PH "Evaluation of the Abbott IMx automated immunoassay of prostate-specific antigen." Clinical chemistry 1992 Oct; 38; 10; 2044-54
  
  
• Takayama TK, Krieger JN, True LD, Lange PH "Recurrent prostate cancer despite undetectable prostate specific antigen." The Journal of urology 1992 Nov; 148; 5; 1541-2
  
  
• Brawer MK, Bigler SA, Sohlberg OE, Nagle RB, Lange PH "Significance of prostatic intraepithelial neoplasia on prostate needle biopsy." Urology 1991 Aug; 38; 2; 103-7
  
  
• Lange PH "Prostate-specific antigen for staging prior to surgery and for early detection of recurrence after surgery." The Urologic clinics of North America 1990 Nov; 17; 4; 813-7
  
  
• Lange PH "Prostatic specific antigen in diagnosis and management of prostate cancer." Urology 1990 Nov; 36; 5 Suppl; 25-9
  
  
• Brawer MK, Lange PH "Prostate-specific antigen in management of prostatic carcinoma." Urology 1989 May; 33; 5 Suppl; 11-6
  
  
• Lange PH, Brawer MK "Serum prostate-specific antigen: its use in diagnosis and management of prostate cancer." Urology 1989 Jun; 33; 6 Suppl; 13-7
  
  
• Lange PH "Controversies in management of apparently localized carcinoma of prostate." Urology 1989 Oct; 34; 4 Suppl; 13-8; discussion 46-56
  

Awards & Honors

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