Dr. Muller is a UW Lecturer in Urology and Biological Structure, whose interests are in the field of male reproduction. He completed his undergraduate and master's training in zoology and embryology at the University of Colorado, Boulder. He received his PhD degree in reproductive endocrinology from the University of California, Berkeley. He is certified through ABB as a Director of High Complexity Laboratories.
Client Care Philosophy
He believes in a considerate and professional approach to clients who seek an evaluation for male infertility. His laboratory works closely with physicians who are experts in male and female reproductive health to offer the best possible care to infertile couples.
Scope Of Care
Laboratory tests for semen analysis and sperm dysfunction. Laboratory preparation of sperm for freezing (cryopreservation). Laboratory preparation of sperm for insemination. Analysis of testicular and epididymal surgical specimens for presence of sperm and preparation for insemination or cryopreservation.
Common conditions analyzed: male infertility, vasectomy check, azoospermia, retrograde ejaculation.
Common diagnostic tests and procedures: semen analysis, sperm morphology, semen reactive oxygen testing, sperm DNA fragmentation testing (COMET), fine-needle aspirate mapping of the testes, preparation of sperm from testicular aspiration (TESA), testicular extraction (TESE), or epididymal sperm aspiration (PESA/MESA).
He is an enthusiastic world traveller, photographer, gardener, hiker, and skier. He is President or Past-President of local rhododendron societies.
As Director of a Clinical Laboratory, Dr. Muller develops and provides state-of-the-art testing services for physicians and patients through the Male Fertility Laboratory. His main interests are male infertility, sperm dysfunctions, and sperm DNA damage.
His background in reproductive biology and embryology forms the foundation of his research interests.
He mentors undergraduate, graduate, post-graduate, medical students, and MD residents in laboratory studies and clinical trials. He teaches Microscopic Anatomy (Histology) to first-year medical students.
Male Reproductive Physiology, Endocrinology, Infertility, Clinical Laboratory Tests
Education & Training
Dr. Muller received his BA and MA in Biology/Zoology at the University
of Colorado, Boulder, and his PhD in Zoology (Comparative Endocrinology)
at the University of California, Berkeley. As a postdoctoral research
fellow, he studied at The University of Texas at Austin and University
of California, Berkeley. At the University of Washington, he has held
faculty positions in the Departments of Biological Structure and Obstetrics
Singh, N.P, C.H. Muller and R.E. Berger 2003 Effects of age on DNA double
strand breaks and apoptosis in human sperm. Fertil. Steril.
Muller, C.H., R.E. Berger, L. Mohr and J.N.Krieger 2001 Comparison of
microscopic methods for detecting inflammation in expressed prostatic
secretions. J. Urol. 166: 2518-2524.
Muller, C.H. 2000 Rationale, interpretation, validation, and uses of
sperm function tests. J Androl. 21: 10-30.
Burton, K.A., B. Treash-Osio, C.H. Muller, E.L. Dunphy and G.S. McKnight
1999 Deletion of type IIalpha regulatory subunit delocalizes protein
kinase A in mouse sperm without affecting motility or fertilization. J
Biol Chem. 274 (34): 24131-136.
España, F., J. Sánchez-Cuenca, P.J. Fernández,
J. Gilabert, A. Romeu, A. Estellés, M. Royo and C.H. Muller 1999
Inhibition of human sperm–zona-free hamster oocyte binding and
penetration by Protein C Inhibitor. Andrologia 31: 217-223.
Shapiro, R.H., C.H. Muller, G.Chen and R.E. Berger 1998 Vasectomy reversal
is associated with increased reactive oxygen species production by seminal
fluid leukocytes and sperm. J Urol. 160:1341-6.
Alexander, B.H., H. Checkoway, E.M. Faustman, C. van Netten, C.H. Muller,
and T.G. Ewers 1998 Contrasting associations of blood and semen lead
concentrations with semen quality among lead smelter workers. Amer
J Industr Med. 34:464-469.
Muller, C.H., R.W. Coombs and J.N.Krieger 1998 Effects of clinical stage
and immunological status on semen analysis results in Human Immunodeficiency
Virus Type 1-seropositive men. Andrologia 30 (Suppl. 1): 15-22.
Muller, C. and K. White 1996 Over the Doshong La: Exploring Kingdon-Ward's ‘Rhododendron
Fairyland' in Southeastern Tibet. J Amer Rhododendron Soc. 50:146-153;
Kreiger, J.N., R.E. Berger, S.O. Ross, I. Rothman and C.H. Muller 1996
Seminal fluid findings in men with nonbacterial prostatitis and prostatodynia. J
Branigan, E.F., L.R. Spadoni and C.H. Muller 1995 Identification and
treatment of leukocytospermia in couples with unexplained infertility. J
Reprod Med. 40:625-629.
Ravnik, S.E., J.J. Albers and C.H. Muller 1995 Stimulation of human
sperm capacitation by purified lipid transfer protein. J Exp Zool.
Muller, C.H. and Ravnik, S.E. 1995 Lipid Transfer Protein: A natural
stimulator of the sperm capacitation process. In: P. Fenichel and J.
Parinaud, Eds. Human Sperm Acrosome Reaction, Paris, Colloque
Muller, C.H. 1992 The andrology laboratory in an Assisted Reproductive
Technologies program: Quality assurance and laboratory methodology. J
full PubMed list of articles
Awards & Honors