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Department of Urology
University of Washington | School of Medicine
Department of Urology

Diseases & Conditions

Urinary Tract Infection (UTI)

Authors: Jean M. Kallhoff, ARNP
Last updated: April 5, 2006

Overview

Urinary tract infections are far more common of the bladder than of any other structure in the urinary tract. An infection that occurs in the lower urinary tract, most commonly of the bladder, is easily treated with a short course of usually 3 days of antibiotics. Less commonly the urinary tract infection is in the kidneys, which requires a longer course of antibiotics. Females are more likely to get urinary tract infections than males.

Symptoms

Bladder infection:

  • Pain or burning when urinating
  • Frequent need to urinate
  • Urgent need to urinate
  • Blood in the urine
  • Discomfort in the middle of the lower abdomen (suprapubic pain)

Kidney infection:

  • fever
  • flank/side/back pain
  • blood in the urine
  • nausea or vomiting

Causes

The urinary tract is normally sterile and does not have bacteria present. If bacteria enter the urinary tract, they multiply and cause a urinary tract infection. E. coli is the most common bacteria causing urinary tract infections.

Risk Factors

Some women are prone to recurring episodes of bladder infections and the risk increases with the following:

  • Sexual activity
  • Use of spermicides, particularly in combination with a diaphragm
  • Genetic factors, which enhance bacterial adherence to the cells of the urinary tract
  • A new sex partner

Underlying conditions such as indwelling bladder catheter, recent procedure involving the urinary tract, anatomic abnormality of the urinary tract, neurogenic bladder, pregnancy, diabetes, age 65 years, or any blockage of the urinary tract can sometimes lead to UTIs that are more complicated than simple bladder infections. Males who engage in insertive anal intercourse are more likely to have urinary infections.

Diagnosis

A history of painful urination, urgency, frequency can be indications of a urinary tract infection. Testing the urine by checking a 1) urine dipstick, 2) doing a microscopic exam of the urine looking for white blood cells (which the body formed to combat the bacterial infection), and 3) performing a urine culture (the bacteria are grown so we can determine the type of bacteria and which antibiotic best treats that bacteria) are ordered to evaluate for an infection. You may be examined for presence of fever or flank pain which would suggest the possibility of a kidney infection.

If the above tests show no evidence of an infection despite painful urination, urgency and frequency treatments other than antibiotics are indicated.

Complications

There are very few complications to the most common urinary tract infection which is a bladder infection. Bladder infections do not lead to kidney infections in healthy urinary tracts without anatomic abnormalities.

Treatment

Nitrofurantoin (Macrobid), trimethoprim-sulfamethoxazole (Bactrim), ciprofloxacin (Cipro) or levofloxacin (Levaquin). Pyridium to numb the bladder pain can be used for comfort for several days.

Self-care

If using spermicides and diaphragm for contraception explore other contraceptive. Although research has not proven 1) maintaining a good fluid intake or 2) emptying the bladder after intercourse to be helpful, these activities are often recommended. In a small research study cranberry decreased the bacterial adherence to the cells of the urinary tract, however the cranberry did not clearly reduce the number of urinary tract infections. Research is ongoing. It is reasonable to try cranberry tablets and evaluate whether there is reduced urinary tract infections.

Patients with cultures documenting recurrent urinary tract infections can be offered treatment with

  1. daily low dose antibiotic for urinary tract infection suppression for 6 months;
  2. if urinary tract infections are related to sexual activity a low dose antibiotic taken at the time of intercourse is helpful; or
  3. self treatment with antibiotics is occasionally recommended when urine cultures are consistently positive.

Patients without urinary tract infections, who have symptoms of urgency, frequency and painful urination with negative urine cultures can stop cranberry intake and determine if their symptoms improve.

Related Conditions

Lower urinary tract infection: Cystitis, Bladder infection, UTI

Upper urinary tract infection: kidney infection, pyelonephritis.

>>View all articles.

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