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Peyronie's Disease

Overview

Peyronie’s Disease is common fibrotic disorder of the penile erectile bodies that causes varying degrees of penile deformity and sexual dysfunction.   Its exact causes are unknown, but probably the condition represents an abnormal response to injury in susceptible individuals. The structure injured is the tunica albuginea, the fibrous white coat that surrounds the erectile bodies of the penis. Most often, the precipitating trauma is a bending injury to the erect penis.; However, other causes such as urethral catheterization, blunt trauma to the flaccid penis, and medications have been reported.  A Peyronie’s plaque is the thickened fibrous inflammatory nodule that is usually palpable along the shaft of the penis. Disordered collagen fibers and loss of elasticity prevent the expansion of the tunica albuginea  during erection and this is directly responsible for the symptoms.



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