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University of Washington Department of Urology Seal University of Washington | School of Medicine
Department of Urology
University of Washington | School of Medicine
Department of Urology

Thomas Takayama, MD

>>Takayama bio

Prostate Cancer Serine Protease Lab

Research Interests

We are very interested in studying the potential role of serine proteases in the biology of prostate cancer. Our goals are three-fold: (1) to make and biochemically characterize serine proteases secreted by the human prostate gland, (2) study the role(s) of Protease-activated Receptors (PARs) in prostate cancer progression, and (3) determine the expression pattern of serine proteases and PARs in prostate cancer.

Active projects

  1. Recombinant serine protease characterization of hK2, hK3, hK4, hK15.
  2. Analysis of PAR-1, PAR-2, PAR-4 cell-signaling.
  3. Immunohistochemistry of kallikreins and PARs in prostate cancer.

Current and Past Funding:

  1. Department of Defense - New Investigator Award for prostate cancer (DAMD - CDMRP grant)
  2. SMT scholar fund
  3. National Institutes of Health grant
  4. American Cancer Society grant

Lab Members:

Gregory Mize

Wenbin Wang, PhD

Xiaotun Zhang, MD

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