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Pathways Study
Funded by the National Institutes of Health

UW Autism Center

What is the purpose of this study?

The Pathways Study is a longitudinal follow-up of children with autism spectrum disorders (ASD) who have previously participated in a randomized controlled trial of a two-year, early intensive behavioral intervention (Toddler Assessment Project).  The intervention integrates applied behavior analysis (ABA) methods with play-based and parent-training methods designed to promote social reciprocity and affective engagement. 

This follow-up study allows us to test directly whether early intervention designed to increase cognitive and social competence and reduce core autism symptoms may change brain activity at the electrophysiological level while having the additional effect of reducing levels of associated symptoms, including repetitive and stereotyped behaviors and externalizing and internalizing behaviors

Children with ASD from the UW intervention and community groups are being re-evaluated at the age of six years in an effort to assess long-term differences between treatment groups.  Evaluations involve measures used for autism diagnosis, cognitive assessment, language assessment, social/play skills, and an EEG.  We are also analyzing salivary cortisol from these children to examine whether those who received early intensive intervention have more adaptive physiological stress responses.  Parents and teachers of these children are also being asked to complete questionnaires. Later on, a feedback session, either via phone or in person based on the parent’s preference, is conducted to review the subject’s evaluation and to provide any referrals and recommendations that might be helpful for the family.

Who are the researchers involved in this project?

Annette Estes, PhD  (Principal Investigator)
Bryan King, MD  (Co-Principal Investigator)
Jessica Greenson, PhD  (Co-Investigator)
Raphael Bernier, PhD (Co-Investigator)
Tanya St. John, PhD  (Co-Investigator)
Lena Tsui, MA  (Research Coordinator)

Whom should I contact to get involved?

We are no longer recruiting for this study.  Families currently participating in this study have previously participated in our Toddler Assessment Project.  To learn more about participating in any of our other studies, please contact our project scheduler at 1.877.408.UWAC.

UW Autism Center
Box 357920
Seattle, WA 98195

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