May 01, 2014

BioE Seminar Series: DNA 2.0, Kedar Patel

5:30pm-6:30pm | Foege N130A

Participating Company

  • DNA 2.0 logo

“A Unique Synthetic Biology Platform for the Efficient Engineering of Biological Systems”

Talk Abstract

Advances in synthetic biology enable the facile design and creation of novel biological systems. The field is now maturing into an engineering discipline, accelerating the development of biologically engineered solutions to problems in various areas including healthcare, fuels and chemicals as well as materials.

We have developed a bioengineering platform that is based on the seamless integration of synthetic biology, efficient gene synthesis and modern machine learning to address whole bio-system optimization. The platform enables simultaneous exploration of a large number of variables ranging from synonymous mutations via amino acid substitutions and DNA/protein parts all the way through pathway replacement and genome editing at the chromosomal level while minimizing the sample numbers needed. We manage the large size of possible sequence space by condensing the dimensionality and capturing correlating variables. Causal variables are identified and their relative contribution quantified by iterative rounds of systematic exploration. The technology is generic and broadly applicable in biology and can be used within existing QbD (Quality by Design) processes to capture and interrogate design information much upstream of typical industrial scale QbD.

We will describe several independent unpublished case studies illustrating the efficiency and power of the technology.

Speaker Biography

Kedar Patel, PhD is an experienced scientist and manager (Synthetic Biology, Biotechnology, Protein Engineering). He is developing DNA assembly and strain engineering technologies at DNA2.0. He holds MS and PhD degrees in Chemical Engineering from Stanford University (California, USA). Over the past 13 years in the field, Kedar has held positions at a number of pioneering San Francisco bay area biotechnology companies (Kosan Biosciences Inc., Amyris Biotechnologies Inc., DNA2.0 Inc.). He has authored and co-authored numerous scientific papers in peer reviewed journals and holds several patents. He actively participates in conferences related to his areas of expertise and is a member of relevant professional societies. Below are some of the areas in which Kedar has significant expertise.

  • High throughput gene synthesis, DNA assembly and engineering of microbes
  • Next generation genome editing technologies (TALEns, CRISPR)
  • Protein engineering, non-natural amino acid incorporation, protein conjugation

UW Bioengineering departmental seminars are held Thursdays during Winter and Spring quarter (January-June), and offer invited researchers a forum to discuss scientific problems related to bioengineering. Open discussion of problems is desired.

The seminar is open to members of the public and is also offered as an academic course (BIOEN 509).

BIOE-AP Event Parking Instructions

Thank you for joining us for the Industry Spotlight: Molecular & Cellular Engineering workshop, put on by the UW Bioengineering Affiliates Program!

Please stop at Gatehouse 6 on Columbia Road behind the UW Medical Center to receive a parking pass. Evening parking is $5.00 for the night. We will validate your parking.

The W.H. Foege Building is located adjacent to Health Sciences on the corner of 15th & NE Pacific.

Driving Directions to UW Gatehouse 6:

From I-5

- Take the NE 45th Street exit (#169)

-Turn onto NE 45th Street

-Continue east about one quarter mile to 15th Avenue NE and turn right

-Continue on 15th Ave NE to Columbia Rd and turn left

-Proceed to the Gatehouse to receive your parking assignment

 

From SR520

-Take the Montlake Boulevard exit

-Continue north on Montlake Blvd. and cross the drawbridge

-At the first traffic light after the bridge, turn left onto NE Pacific Street.

-Proceed west on NE Pacific to 15th Avenue NE, turn left on 15th Ave NE

-Continue to Columbia Rd and turn left

-Proceed to the Gatehouse to receive your parking assignment