We will report on the design of systems wherein a reconfiguration of the materials can be triggered chemically of mechanically. The utility of these methods is to generate transduction mechanisms by which chemical and biological sensors can be developed. The systems to be discussed will include. (1) Assemblies of polymers at air water interfaces and the demonstration of a luminescence strain response upon compression. (3) Dynamic colloids produced from immiscible fluorocarbon/hydrocarbon mixtures and ability to convert the core and shell layers of the particles as well as the conversion to Janus particles. The latter system’s morphology changes can be triggered chemically or optically.