Inherently conductive polymers (ICPs) have great potential for a variety of aerospace applications including electrostatically dissipative coatings for canopies and surfaces, next generation wiring, conductive composites, lightning protection and high power energy storage systems. In many of these applications polymers with truly metallic behavior are a necessity. This presentation will review some of the challenges involved in applying advanced computational methods to conductive polymer synthesis, processing and formulation. The development of novel, environmentally durable aerospace coatings will be presented as a case-study in closed-loop computation-experimentation.