She founded Adelphi University's dance program in 1938, which was the one of the first dance departments in an American university. It has since become a cornerstone of Adelphi's Department of Performing Arts. Her early works are indicative of her interests in exotic mysticism and spirituality. Many companies currently include a collection of her signature solos in their repertoires, including the programme, "The Art of the Solo," a showcase of famous solos of modern dance pioneers. Several early St. Denis solos (including Incense and The Legend of the Peacock) were presented on September 29, 2006, at the Baltimore Museum of Art.
One of her more famous pupils was Martha Graham, who attended Ms. St. Denis' school of dance, Denishawn, which she had started with her husband, Ted Shawn. Doris Humphrey and Charles Weidman also studied at Denishawn, and, Graham, Humphrey and Weidman all served as student dancers with the Denishawn company. Ruth St. Denis and Ted Shawn were also instrumental in creating the legendary dance festival, Jacob's Pillow.